A5069891524- Inflammatory Bowel Disease
- Microscopic Colitis
- Esophageal and GI Pathology
- Inflammasome and immune disorders
- Autoimmune and Inflammatory Disorders Research
- Autoimmune and Inflammatory Disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Hepatitis C virus research
- Gastroesophageal reflux and treatments
- Clinical Nutrition and Gastroenterology
- Ocular Diseases and Behçet’s Syndrome
- Pancreatitis Pathology and Treatment
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Treatments and Studies
- Eosinophilic Esophagitis
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Abdominal vascular conditions and treatments
- Infection Control and Ventilation
- Rheumatoid Arthritis Research and Therapies
- Celiac Disease Research and Management
- Medical Device Sterilization and Disinfection
- Listeria monocytogenes in Food Safety
- Musculoskeletal synovial abnormalities and treatments
Hirosaki University
2014-2025
Kyushu University
2012-2015
Capsule endoscopy has been widely used as a non-invasive diagnostic tool for small or large intestinal lesions. In recent years, automated lesion detection systems using machine learning have devised. This study aimed to develop an system capsule endoscopic severity in patients with ulcerative colitis along the entire length of colon ResNet50. videos from were collected prospectively. Each single examination video file was partitioned into four segments: cecum and ascending colon, transverse...
Background: Maintenance of mucosal healing may lead to a better outcome in patients with Crohn's disease (CD). Magnetic resonance diffusion-weighted imaging (MR-DWI) scans 1 year after infliximab (IFX) induction therapy were assessed as predictors maintained response, or remission, through 3 years treatment CD. Summary: MR-DWI and endoscopy data prospectively collected throughout IFX treatment. Altogether, 86 lesions from 13 given (weeks 0, 2 6) maintenance (5 mg/kg every 8 weeks beginning...
Currently, the number of patients treated with immune-checkpoint inhibitor involving nivolumab is increasing. Nevertheless, it causes various immune-related adverse events (irAEs). Here, we report case a patient who underwent long-term follow-up after suffering from nivolumab-associated colitis. The was 57-year-old man resection bladder tumor. Following surgery, lymph node metastasis detected, and he by nivolumab. Two months treatment nivolumab, complained bloody diarrhea. Colonoscopy...
Bongkrekic acid (BKA) is an inhibitor of adenine nucleotide translocase (ANT). Since inhibition ANT connected to the cytochrome c release from mitochondria, which then results in suppression apoptosis, it has been used as a tool for mechanistic investigation apoptosis. BKA consists long carbon chain with two asymmetric centers, nonconjugated olefin, conjugated dienes, three methyl groups, methoxyl group, and carboxylic acids. This complicated chemical structure caused difficulties synthesis,...
Recently, the importance of achieving clinical and deep remissions with mucosal healing (MH) has been demonstrated as a therapeutic goal to avoid Crohn's disease (CD) surgical operations. Although ileocolonoscopy (CS) is considered gold standard, there are increasing reports on benefits capsule endoscopy (CE) serum leucine-rich α2-glycoprotein (LRG) for evaluating small-bowel lesions in CD. We evaluated data 20 patients CD who underwent CE our department between July 2020 June 2021 whose LRG...
Thiopurines are key drugs for inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's (CD). Recently, NUDT15 polymorphism (R139C, c.415C > T) has been shown to be associated with thiopurineinduced adverse events in Asian populations. In patients the C/T genotype, low-dose thiopurine treatment is recommended, but its long-term efficacy tolerability remain unclear. This study aimed uncover appropriate dosage of IBD genotype. A total 210 (103 UC 107 CD) determined have...
We describe herein a case of severe relapsed pyoderma gangrenosum (PG) concomitantly with pouchitis treated by tacrolimus. A 25-year-old woman had undergone proctocolectomy construction ileo-anal pouch surgery for refractory ulcerative colitis (UC). She first developed PG pouchitis, and infliximab (IFX) was administered to induce remission due resistance glucocorticoid therapy. After achieving remission, IFX stopped. Five years later, skin ulcers recurred treatment 30 mg oral prednisolone...
Objective Two-dimensional shear wave elastography (2D-SWE) is a new ultrasound-based method to evaluate liver fibrosis in the daily practice. However, utility of 2D-SWE among other markers unclear. Methods We enrolled 141 consecutive patients with hepatitis C virus infection, 66 men and 75 women (median age, 67 years), who underwent biopsy (LOGIQ E9, GE Healthcare, Wauwatosa, WI, USA). compared diagnostic accuracy those magnetic resonance (MRE; MR-Touch, Milwaukee, USA), Mac-2 binding...
Bongkrekic acid, isolated from Burkholderia cocovenenans, is known to specifically inhibit the mitochondrial ADP/ATP carrier. However, manner of its interaction with carrier remains elusive. In this study, we tested inhibitory effects 17 bongkrekic acid analogues, derived intermediates obtained during total synthesis, on ATP/ATP Rough screening these chemicals, performed by measuring their ATP revealed that 4 them, KH-1, KH-7, KH-16, and KH-17, had moderate effects. Further characterization...
Myelodysplastic syndromes (MDSs) are a group of myeloid neoplasms characterized by blood cell deformation and dysfunction, MDS with trisomy 8 is closely linked intestinal Behçet's-like diseases. Intestinal disease refractory to conventional therapies, including prednisolone, immunomodulators, anti-tumor necrosis factor α agents. Here, we describe 56-year-old woman ascribed who had multiple intractable ulcers. She presented periodic fever abdominal pain. The genetic analysis showed...
Vitamin A ensures intestinal homeostasis, impacting acquired immunity and epithelial barrier function; however, its role in innate is mostly unknown. Here, we studied the impact of vitamin different dextran sulfate sodium (DSS)-induced colitis animal models. Interestingly, more severe DSS-induced was observed A-deficient (VAD) mice than A-sufficient (VAS) mice; same VAD combined immunodeficient lacking T/B cells. Remarkably, IL-1β production, LC3B-II expression, inflammasome activity lamina...
A 60-year-old woman was admitted for the treatment of a gastric neuroendocrine tumor (NET) associated with type chronic atrophic gastritis. The lesion measured 10 mm in diameter, and computed tomography scan did not reveal any metastatic lesions. Endoscopic submucosal dissection (ESD) subsequently performed. histological examination revealed three NETs, two which exhibited vessel invasion. Endocrine cell micronests high risk recurrence were also observed. Therefore, patient underwent total...
Fever of unknown origin (FUO) is caused by various diseases, making differential diagnosis difficult. This study aimed to determine the clinical features patients with FUO for use in daily medical practice. Medical records who first visited our department between January 2008 and December 2017 were reviewed. We classified diagnostic categories as infection, non-infectious inflammation, neoplasm, others, unidentified through definitive compared characteristics fulfilled criteria classical...
Esophageal endoscopic submucosal dissection (ESD) is considered to be more complex than gastric ESD. This study aimed assess the physical invasiveness of esophageal ESD during perioperative periods by measuring resting energy expenditure (REE). The factors affecting REE that could used identify patients requiring management were also investigated. Overall, 75 who had undergone prospectively enrolled. REE, body weight, and basal measured on day following mean REE/body weight was 20.2...
Esophageal achalasia is a typical esophageal motility disorder (EMD). Although viral infections have been hypothesized to play role in the pathogenesis of achalasia, its etiology remains unclear. This study used muscle layer specimens collected during per-oral endoscopic myotomy (POEM) procedures investigate association between and esophagogastric junction outflow obstruction (EGJOO) pattern recognition receptors.
Background/Aims: Behçet’s disease (BD) with intestinal lesions and Crohn’s (CD) share clinical features. However, no report has compared the 2 diseases regard to of upper gastrointestinal tract (UGT). We aimed evaluate endoscopic histologic findings UGT in CD BD. Methods: retrospectively assessed records biopsy samples 84 Helicobacter pylori-negative patients (50 CD, 34 BD). In duodenal samples, MUC5AC immunohistochemical analysis was performed identify gastric foveolar metaplasia. Results:...
Objective: Crohn's disease (CD) and Behcet's (BD) are two major causes of inflammatory lesions in the small bowel. For detecting such lesions, most sensitive exam is small-bowel capsule endoscopy (CE), an imaging modality suitable for evaluating intestine, with a relatively low rate retention. However, few reports have employed CE to compare inflammation early CD that BD. Thus, aim our study was obtain systematic characterization BD by using CE. Methods: This retrospective single-center...
Gastrointestinal endoscopy increases the risk of bacterial exposure to endoscopists. However, before 2019, most endoscopists did not pay attention microorganism transmission from patients. This study aimed investigate incidence endoscopists' faces during gastrointestinal endoscopic procedures using culture method.This was a single-centered, retrospective including who performed various at Division Endoscopy, Hirosaki University Hospital between August 31 and October 6, 2020. Endoscopists...
Surgery avoidance is an important goal in Crohn’s disease (CD) treatment and predicting the risk of subsequent surgery to determine adequate therapeutic strength for patients with newly diagnosed CD. Herein, we aimed construct a prediction model based on characteristics at patients’ initial visit. We retrospectively collected characteristic data from 93 A logistic regression brute force method was used maximize area under receiver operating curve (auROC) by employing combination potential...
Transforming growth factor β (TGFβ) signaling plays a key role in modulating intestinal epithelial cell (IEC) homeostasis. The present study aimed to investigate the direct effect of tacrolimus on TGFβ IECs.The protective effects tacrolimus, with or without anti-TGFβ antibody, dextran sulfate sodium (DSS)-induced colitis were evaluated.Tacrolimus ameliorated IEC apoptosis-mediated mucosal destruction despite treatment. receptor type II (TGFβ-RII), phosphor-SMAD family members 2/3, and...