A5056810525- Neurological disorders and treatments
- Peripheral Neuropathies and Disorders
- Parkinson's Disease Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Pain Mechanisms and Treatments
- Liver Disease Diagnosis and Treatment
- Meteorological Phenomena and Simulations
- Climate variability and models
- Neuroscience and Neuropharmacology Research
- Autoimmune Neurological Disorders and Treatments
- Peripheral Nerve Disorders
- Proteins in Food Systems
- Genetic Neurodegenerative Diseases
- Hereditary Neurological Disorders
- Mitochondrial Function and Pathology
- Pharmacogenetics and Drug Metabolism
- Amyotrophic Lateral Sclerosis Research
- Colorectal Cancer Screening and Detection
- Neurological diseases and metabolism
- Acute Ischemic Stroke Management
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Magnetic and Electromagnetic Effects
- Multiple Sclerosis Research Studies
- Biomedical Ethics and Regulation
- Pharmacy and Medical Practices
Hirosaki University
2006-2025
Hiroshima Kyoritsu Hospital
2017-2024
Japan Agency for Marine-Earth Science and Technology
2014-2024
Saga University
2016-2023
Japan Women's University
2023
National Institute of Occupational Safety and Health
2023
Tohoku Seikatsu Bunka University
2023
Hirosaki University Hospital
2020-2021
Hirosaki National Hospital
2021
Anjo Kosei Hospital
2018-2020
Abstract To evaluate the impacts of global warming on local‐scale extreme precipitation in Japan, 720‐year ensemble dynamical downscaling is conducted by a regional climate model with 5 km grid spacing. Our based large data set called database for Policy Decision making Future change (d4PDF). Comparing historical and 4K climates, annual maximum daily hourly are enhanced over Japan due to warming. The increasing rate larger coast Pacific Ocean eastern western northern parts Japan. periods...
The effects of human rIL-6/B cell stimulatory factor 2 (hrIL-6/BSF-2) from Escherichia coli on murine Ag, SRBC-specific antibody responses were examined in vitro and vivo. HrBSF-2 was effective augmenting the primary anamnestic plaque-forming cells response to SRBC vitro. augmentation apparent when B cell-enriched spleen (B cells) cultured with BSF-2 presence IL-2. On other hand, hrBSF-2 alone strongly enhanced a dose-dependent manner SRBC-immunized mice used. These abolished completely by...
ABSTRACT Maladaptive plasticity at corticostriatal synapses plays an important role in the development of levodopa‐induced dyskinesia. Recently, it has been shown that synaptic is closely linked to morphologic changes dendritic spines. To evaluate spines two types striatal medium spiny neurons, which project internal segment globus pallidus or external pallidus, dyskinesia model, we used 6‐hydroxydopamine‐lesioned rats chronically treated with levodopa. Dendritic were decreased and became...
We aimed to create a rat model of drug-induced parkinsonism and tardive dyskinesia by chronic administration haloperidol examine the expression direct indirect pathway markers in striatum rats. treated 21 rats, 14 with decanoate 7 placebo. The number vacuous chewing movements per 2 min was counted, haloperidol-treated rats were classified into two groups: mild severe dyskinesia. Other behavioral analyses also conducted. After 6-month treatment period, brains removed, protein evaluated...
Recently, a novel deep learning (DL)-based technique for reconstructing highly undersampled MR data (DL-Speed, DLS) has been developed, which demonstrated superior performance over compressed sensing. This study aimed to achieve high-resolution double inversion recovery (DIR) imaging using DLS (DLS-DIR) and compare its diagnostic in the detection of juxtacortical multiple sclerosis (MS) lesions with that conventional DIR (C-DIR). We retrospectively analyzed MRI from 25 patients MS who...
<title>Abstract</title> The prevalence of deep vein thrombosis (DVT) is high in patients with severe major neurocognitive disorders and motor deficits. However, it unknown whether mild cognitive decline without deficits have an increased risk for DVT. Recently, Nakanishi et al. proposed the Himi score to evaluate DVT frail elderly individuals. accounts independence level daily life among dementia, graded as I/II, III, IV M, assessment item. In present study, we investigated decline....
Six novel nonsynonymous nucleotide alterations were found in the cytochrome P450 1A2 gene a Japanese population, which resulted following amino acid substitutions: T83M, E168Q, F186L, S212C, G299A, and T438I. These individuals heterozygous for substitutions. The potential functional caused by substitutions characterized cDNA-mediated expression system using Chinese hamster V79 cells. Among six CYP1A2 variants, F186L showed most profound statistically significant reduction...
Background. It is often difficult to differentiate Parkinson's disease (PD) from multiple system atrophy (MSA), especially in their early stages. Objectives. To examine the clinical utility of histopathological analysis biopsied skin chest wall and/or leg differentiating between two diseases. Methods. Skin biopsies lower anterior were obtained 38 patients with idiopathic PD (26 treated levodopa and 12 levodopa-naïve) 13 age-matched MSA. We sought aggregates phosphorylated α-synuclein on...
Liquid biopsies are not used in practice for hepatocellular carcinoma (HCC). Epi proColon is the first commercial blood-based test colorectal cancer screening based on methylated DNA testing of septin 9 gene (SEPT9). However, has some disadvantages, including requirement a large amount blood and lack quantitative performance. Therefore, we previously developed novel liquid biopsy that can quantitatively detect even single copy SEPT9 small DNA. In current study, evaluated application...
To investigate peripheral and central somatosensory conduction in patients with diabetes.The authors recorded sensory nerve action potentials 5-channel evoked (SEPs) noncephalic reference after median stimulation 55 diabetes 41 age- height-matched normal subjects. The determined onset or peak latencies of the Erb's potential (N9) spinal N13-P13 cortical N20-P20 components, obtained time (CCT) by onset-to-onset peak-to-peak measurements.Both all SEP components were prolonged diabetes. mean...
The synergistic action of interleukin 6 with 3 on the proliferation a murine hemopoietic stem cell population in short-term liquid culture system was examined by radioprotective assay. numbers colony-forming units spleen (CFU-S), together granulocyte/macrophage and viable nucleated cells, were found to increase markedly presence both IL-3 IL-6, compared or IL-6 alone. peak CFU-S value response combination obtained days after initiation, exceeding 5-fold input value. Consistent these data,...
Abstract To determine the role of norepinephrine transporter in reuptake L ‐DOPA‐derived extracellular DA DA‐denervated Parkinsonian striatum, we examined levels striatum 6‐hydroxyDA‐lesioned rats that received ‐DOPA (50 mg/kg with 12.5 benserazide) and plus desipramine (25 mg/kg), a selective inhibitor, using vivo microdialysis. The pretreatment increased derived from administrated striatum. This study provides evidence is taken up by transporter, instead dopamine dopaminergic denervation....
We examined whether previous experience of repeated skin punctures altered the correlation between prefrontal cortical pain responses and Premature Infant Pain Profile (PIPP) scores, compared with infants who had no puncture.Eighty at 37-42 weeks gestational age were observed during clinically required blood sampling: full-term painful skin-breaking procedures before data collection (controls; n = 30), (n 20) preterm 30).We found significant differences in PIPP scores among groups. In...
ABSTRACT Introduction The loss of epidermal nerve fibers is regarded as an early pathological change in human diabetes. We investigated Aδ fiber function by examining pain threshold means intraepidermal electrical stimulation (IES) diabetic neuropathy. Methods recruited 20 asymptomatic patients. Eighteen age‐matched, healthy subjects served controls. placed the IES electrode onto skin foot dorsum and delivered weak stimulation. defined minimum intensity at which a subject felt pricking...
The statistical problems of chains are divided into three classes i,e. ideal type, real type and production these types the chain investigated by use relatively short lattice chains. We performed complete enumeration dimensions two-dimensional square up to bond number N =20 dimensional simple cubic =8. As for mean end-to-end distance < R 2 >, we obtained results that have always larger values >/ than its value seems diverge as →∞. distribution distances has a form which appreciably deviates...
Injection of pig serum into rats twice a week for 8 weeks induced stellate cell activation resulting in liver fibrosis without parenchymal injury. Administration choline deficient L–amino acid defined (CDAA) diet 6 with or pretreatment led to the development preneoplastic lesions that were positive placental form glutathione S–transferase (GSTP). Pig more activated cells livers subsequently fed CDAA compared alone. Activated detected as α smooth muscle actin (αSMA)–positive and by expression...
Early onset ataxia with ocular motor apraxia and hypoalbuminaemia/ataxia-oculomotor 1 is a recessively inherited caused by mutations in the aprataxin gene. We previously reported that patients frameshift exhibit more severe phenotype than those missense mutations. However, reports on genotype-phenotype correlation early hypoalbuminaemia are controversial. To clarify this issue, we studied 58 from 39 Japanese families, including 40 homozygous for c.689_690insT nine or compound heterozygous...