A5016814013- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Ultrasound and Hyperthermia Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Renal cell carcinoma treatment
- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Immune Cell Function and Interaction
- Wireless Body Area Networks
- Colorectal and Anal Carcinomas
- Metastasis and carcinoma case studies
- Pediatric Hepatobiliary Diseases and Treatments
- Electromagnetic Fields and Biological Effects
- Wireless Power Transfer Systems
- vaccines and immunoinformatics approaches
- Hepatitis B Virus Studies
- Cancer Research and Treatments
- Pancreatitis Pathology and Treatment
- Cancer Cells and Metastasis
Yamaguchi University
2016-2025
Shikoku Cancer Center
2023
Nakadōri General Hospital
2011-2023
Toyo University
2018-2021
Breast Center
2019
Virginia Commonwealth University Medical Center
2017-2018
Virginia Commonwealth University
2018
Yamaguchi University Hospital
2017
Meiji University
2007-2013
Toshiba (Japan)
2006-2009
Gemcitabine/cisplatin (GC) combination therapy has been the standard palliative chemotherapy for patients with advanced biliary tract cancer (BTC). No randomized clinical trials have able to demonstrate survival benefit over GC during past decade. In our previous phase II trial, adding S-1 (GCS) showed promising efficacy and we aimed determine whether GCS could improve overall compared BTC.We performed a mulitcenter, III trial across 39 centers. Enrolled were randomly allocated (1:1) either...
CD3 + and CD8 T-cell infiltration were reported as positive predictive markers of survival in colorectal cancer (CRC) patients. Here, we demonstrate the prognostic significance CD4 FOXP3 densities CRC. We quantified intratumoural , T cells by immunohistochemistry digital pathology 342 CRC patients who underwent curative resection. Microsatellite instability was also assessed 322 specimens. Patient demographics, clinicopathological features rates analysed. High associated with improved...
We previously conducted a phase I trial for advanced colorectal cancer (CRC) using five HLA-A*2402-restricted peptides, three derived from oncoantigens and two vascular endothelial growth factor (VEGF) receptors, confirmed safety immunological responses. To evaluate clinical benefits of vaccination treatment, we II the same peptides in combination with oxaliplatin-based chemotherapy as first-line therapy. The primary objective study was response rates (RR). Progression free survival (PFS),...
KIF20A (RAB6KIFL) belongs to the kinesin superfamily of motor proteins, which play critical roles in trafficking molecules and organelles during growth pancreatic cancer. Immunotherapy using a previously identified epitope peptide for is expected improve clinical outcomes. A phase I trial combining KIF20A-derived with gemcitabine (GEM) was therefore conducted among patients advanced cancer who had received prior therapy such as chemotherapy and/or radiotherapy. GEM administered at dose 1000...
In the tumor microenvironment, factors inhibiting targeting of cancer cells by activated T have recently been noted. B7-H3 belongs to B7 superfamily immune regulatory ligands and plays an important role in adaptive response co-inhibitory/stimulatory regulating cells. However, degree which directly affects evasion mechanisms remains unclear, particularly patients with breast cancer. Regulatory (Tregs) are known as a key player inhibition mechanisms. The present study demonstrated that...
Background Accumulating evidence shows an over-abundance of Fusobacterium nucleatum in colorectal tumour tissues. Although stool DNA testing might be a potential marker for the detection tumours, difficulty detecting by conventional methods prevented further explorations. Therefore, we developed droplet digital polymerase chain reaction (PCR) assay and investigated its clinical utility management tumours Japanese population. Methods Feces were collected from 60 healthy subjects (control...
We previously conducted a phase I clinical trial combining the HLA ‐A*2402‐restricted KIF 20A‐derived peptide vaccine with gemcitabine for advanced pancreatic cancer ( PC ) and confirmed its safety immunogenicity in patients. In this study, we multicenter, single‐armed, II using two antiangiogenic vaccines targeting VEGFR 1 2 addition to 20A peptide. attempted evaluate benefit of vaccination combination gemcitabine. Chemotherapy naïve patients were enrolled primarily 1‐year survival rate,...
Abstract Background To improve the prognosis of patients with metastatic colorectal cancer (mCRC), investigating predictive biomarkers their and chemotherapeutic responsiveness is necessary. This study aimed to analyze clinical significance serum proteinase-3 (PRTN3) as a predictor for chemosensitivity, especially bevacizumab therapy, in mCRC. Methods single-center retrospective observational enrolled 79 mCRC our hospital 353 TCGA database. Preoperative PRTN3 levels were measured using an...
We previously reported the clinical efficacy of adoptive immunotherapy (AIT) with dendritic cells (DCs) pulsed mucin 1 (MUC1) peptide and cytotoxic T lymphocytes (CTLs). also that gemcitabine (GEM) enhances anti-tumor immunity by suppressing regulatory cells. Therefore, in present study, we performed combination therapy AIT GEM for patients unresectable or recurrent pancreatic cancer. Forty-two cancer were treated. DCs generated culture granulocyte macrophage colony-stimulating factor...
Developing effective adjuvant therapies is essential for improving the surgical outcomes in patients with hepatocellular carcinoma (HCC). Immunotherapy against HCC has become a promising strategy; however, only approximately 30% of all respond to immunotherapy. Previously, we generated novel therapeutic vaccine comprising multi-human leukocyte antigen-binding heat shock protein 70/glypican-3 peptides combination hLAG-3Ig and poly-ICLC. We also confirmed safety this vaccination therapy, as...
Objectives The present multicenter prospective observational study investigated the effectiveness and safety of neoadjuvant chemotherapy (NAC) for patients with borderline resectable pancreatic cancer (BRPC) those RPC contacting major vessels, respect to a historical control upfront surgery. Materials Methods Patients BRPC vessels were prospectively registered administered NAC durations regimens determined by corresponding treating physician. Our primary aim was assess R0 resection rate,...
ABSTRACT Aim This study aimed to investigate the efficacy of radical resection and postoperative adjuvant chemotherapy on survival benefit in patients with pancreatic ductal adenocarcinoma (PDAC), stratified by age, frailty, other factors actual clinical practice. Methods We retrospectively analyzed clinicopathological follow‐up data 414 PDAC who underwent surgical at nine institutions under Yamaguchi Pancreat/Biliary Disease Study Group, between January 1997 December 2016. Recurrence‐free...
The aim of the present study was to characterize infiltrated T cell clones that define tumor immune environment and are important in response treatment patients with advanced colorectal cancer (CRC). In order explore predictive biomarkers for efficacy immunochemotherapies, receptor (TCR) repertoire analysis performed using blood samples tissues obtained from CRC had been treated a combination five‑cancer peptide vaccines oxaliplatin‑based chemotherapy. TCR‑α/β complementary DNAs (cDNAs),...
Liquid biopsies are not used in practice for hepatocellular carcinoma (HCC). Epi proColon is the first commercial blood-based test colorectal cancer screening based on methylated DNA testing of septin 9 gene (SEPT9). However, has some disadvantages, including requirement a large amount blood and lack quantitative performance. Therefore, we previously developed novel liquid biopsy that can quantitatively detect even single copy SEPT9 small DNA. In current study, evaluated application...
Cancer stem cells (CSCs) are thought to play important roles in carcinogenesis, recurrence, metastasis, and therapy-resistance. We have successfully induced cancer stem-like sphere (CSLCs) which possess enhanced chemoresistance metastatic potential. To enable the development of targeted therapy against CSLCs, we identified a gene responsible for this phenotype CSLC.Human hepatoma cell line SK-HEP-1 was used CSLC induction with unique inducing medium, HuH-7 were as non-sphere forming same...
Biliary tract cancer, which includes intrahepatic cholangiocarcinoma, extrahepatic bile duct gallbladder and ampullary is an intractable disease with a dismal prognosis. Prognosis particularly poor in cases involving vessels or lymph nodes. Hepatobiliary pancreatic surgeons worldwide have consistently focused on improving surgical treatment, perioperative management, chemotherapy to improve the outcomes of these diseases. There has been significant progress even last 2 years (2017 2018),...