A5018972258- Cosmology and Gravitation Theories
- Black Holes and Theoretical Physics
- Fluid Dynamics and Turbulent Flows
- Helicobacter pylori-related gastroenterology studies
- Relativity and Gravitational Theory
- Algebraic and Geometric Analysis
- Noncommutative and Quantum Gravity Theories
- Gastric Cancer Management and Outcomes
- Fluid Dynamics and Vibration Analysis
- Quantum and Classical Electrodynamics
- Spectral Theory in Mathematical Physics
- Advanced Differential Geometry Research
- Cold Atom Physics and Bose-Einstein Condensates
- Nonlinear Waves and Solitons
- Wind and Air Flow Studies
- Galectins and Cancer Biology
- Cancer Genomics and Diagnostics
- Geophysics and Sensor Technology
- Wnt/β-catenin signaling in development and cancer
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Wind Energy Research and Development
- Advanced Algebra and Geometry
- COVID-19 and healthcare impacts
- Quantum Mechanics and Non-Hermitian Physics
Yamaguchi University Hospital
2010-2025
Yamaguchi University
1982-2023
University of Hull
2018
Osaka Prefecture University
1975-2012
Kochi Medical School Hospital
2010
Kōchi University
2006-2007
Stability experiments were made on plane Poiseuille flow generated in a long channel of rectangular cross-section with width-to-depth ratio 27·4. By reducing the background turbulence down to level 0·05 %, we succeeded maintaining laminar at Reynolds numbers up 8000, which is much larger than critical number linear theory, about 6000. The downstream development sinusoidal disturbance introduced by vibrating ribbon technique was studied detail various frequencies range from 3000 7500. This...
The experimental evidence on the mechanisms of forcing unstable vorticity waves (the Tollmien–Schlichting–Schubauer or TS waves) circular frequency ω and wavelength λTS in wall layers by unsteady pressure gradients amplitude A is reviewed found to be confused contradictory. It proposed that a likely effective receptivity mechanism rests fact under realistic conditions varies with distance x along any body finite thickness, A(x), introduces thereby additional characteristic lengths which can...
The canonical Wnt signalling pathway is activated in most sporadic colorectal cancers (CRCs). We previously reported that FZD7 functions as a receptor for the colon cancer cells. In this study, we examined function of survival, invasion and metastatic capabilities FZD7_siRNA transfection decreased cell viability HT-29 HCT-116 Expression c-Jun, phosphorylation JNK activation RhoA were suppressed after into vitro activity target gene expression also reduced cells transfected with FZD7_siRNA....
Background Accumulating evidence shows an over-abundance of Fusobacterium nucleatum in colorectal tumour tissues. Although stool DNA testing might be a potential marker for the detection tumours, difficulty detecting by conventional methods prevented further explorations. Therefore, we developed droplet digital polymerase chain reaction (PCR) assay and investigated its clinical utility management tumours Japanese population. Methods Feces were collected from 60 healthy subjects (control...
To control the leading-edge flow separation on an airfoil by means of acoustic excitation, response to incident sound and resulting instability are studied experimentally therically basis linear stability theory, for a flat-plate airfoil, at chord Reynolds number R c =4 x 10 4 .
Background/Objectives: Unrelated bone marrow transplantation (BMT) is a curative treatment for hematological malignancies. While HLA mismatch recognized risk factor in unrelated BMT, the significance of non-HLA single nucleotide polymorphisms (SNPs) remains uncertain. Cytokines play key roles several aspects BMT. Although relationship between cytokine gene SNPs and BMT outcomes has been examined, findings obtained have inconsistent; therefore, further investigations additional cohorts are...
Abstract Although growing evidence demonstrates that TWIST1 is an interesting tumor biomarker, little known about the clinical significance of expression and methylation in human primary colorectal cancer. In this study, we examined association with clinicopathologic features tumors. Primary cancer (CRC) specimens from 319 patients, corresponding normal nontumorous mucosa 251 patients cancer, adenomas 189 were used. Methylation levels compared features. The level was higher adenoma than...
ObjectiveWe evaluated DNA amplificability to achieve a 100% success rate in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissue samples obtained from recent clinical trial.
CT scans are useful in patients with traumatic brain injury (TBI), but the potential risks associated ionizing radiation unknown. Further, not commonly available developing countries. In this study, coagulopathy and abnormal fibrinolysis were investigated as blood biomarkers for detection of structural disorder mild (TBI). A total 88 isolated TBI (Glasgow Coma Scale [GCS] score 14-15) admitted to Kenwakai Ootemachi Hospital between October 2014 March 2016. After exclusion those treated oral...
Although copy number variations (CNVs) are expected to affect various diseases, little is known about the association between CNVs and breast cancer susceptibility. Therefore, we investigated this relation. Array comparative genomic hybridization was performed search for candidate related Subsequent quantitative real-time polymerase chain reaction carried out confirmation. We found seven CNV markers associated with risk. The means of relative numbers patients a history women in control group...
Many biochemical auto-analyzers have methods that measure the hemolysis index (HI) to quantitatively assess degree of hemolysis. Past reports on HI are mostly in vitro studies. Therefore, we evaluated optimal wavelength measurement ex vivo using clinical samples. Four different wavelengths (410/451 nm: HI-1, 451/478 HI-2, 545/596 HI-3 and 571/596 HI-4) were selected for measurement, correlations examined from results 3890 Another set 9446 samples was used examine correlation with lactate...
Abstract The potential risks associated with organs from COVID-19-infected donors were unclear. To determine the SARS-CoV-2 infection status of corneas transplanted during COVID-19 pandemic, we performed a polymerase chain reaction (PCR) using corneal preservation solution that was used for transplantation. We also examined postoperative health recipients. This study included 144 transplants in 143 eyes. Ninety-nine eyes imported and 10 14 donated prefecture PCR tested at our hospital, all...
Abstract Although the fecal immunochemical test for hemoglobin (FIT) is a widely used screening colorectal cancer, it not sensitive enough to detect advanced adenoma. To address this issue, we performed study investigate whether combining FIT and DNA testing of methylated somatostatin ( SST ) could improve diagnostic performance We collected feces from 79 healthy subjects with negative results on colonoscopy, 43 patients non‐advanced adenoma, 117 126 cancer. After was incubated...
Abstract Background: Associations between Helicobacter pylori gene diversity and gastric cancer have not been reported on in Costa Rica, despite its being one of the countries with highest incidence mortality rates world. The aim this study was to determine prevalence H. cagA vacA genes investigate whether it could be correlated atrophic gastritis (AG) (GC) Rica. Materials methods: Genomic DNAs from isolates 104 patients classified into two groups: non‐atrophic group (n = 68) 36), were...
A patient repeatedly developed bacteraemia despite the continuous use of antibiotics. We obtained two Klebsiella pneumoniae isolates from patient's blood on Days 72 and 105 after hospitalization. Each belonged to ST45, but while first isolate was susceptible most antibiotics, second one resistant multiple drugs including carbapenems.To identify genetic differences between uncover alterations formed by within-host bacterial evolution leading antimicrobial resistance.Whole-genome comparison...
Abstract The cell division‐related gene A ( cdrA ) of Helicobacter pylori is dispensable in vivo and unique having a repressive role on division long‐term survival. To clarify its role, comparisons the wild‐type HPK5 isogenic ‐disrupted mutant HPKT510 were examined by ultrastructural morphology, PBP profiles, susceptibility to β‐lactam antibiotics during cultivation. Ultrastructural analyses revealed that shorter rods had slightly wider periplasmic space between inner outer membrane than...
AIM:To investigate into the diversity of UGT1A1 polymorphism across three different districts in Japan and highlight genetic differences among population Japan. METHODS:We enrolled 50 healthy volunteers from each Yamaguchi (western part Japan), Kochi (southern Japan) Akita (northern prefectures.Blood samples (7 mL) were collected participant stored EDTA for subsequent genotyping by fragment size analysis, direct sequencing TaqMan assay *28, UGT1A7 *3/UGT1A9 *22 *93/UGT1A1 *6/ *27/UGT1A1...
To elucidate a potential role for H. pylori BabA and SabA adhesins in the pathogenesis of gastric mucosal lesions, MBS was examined using an in-house ABA-ELISA. Ninety isolates from Japanese patients with cancer (n= 43) non-cancerous 47) lesions were subjected to ABA-ELISA which had been developed in-house, sequential analysis babA2 middle region. The BabA-MBS significantly higher than non-cancer group (P= 0.019), but there no significant difference SabA-MBS. A weak correlation between...