A5046734958- Quantum optics and atomic interactions
- Cold Atom Physics and Bose-Einstein Condensates
- Spectroscopy and Quantum Chemical Studies
- Semiconductor Quantum Structures and Devices
- Quantum and electron transport phenomena
- Strong Light-Matter Interactions
- Spectroscopy and Laser Applications
- Physics of Superconductivity and Magnetism
- Autophagy in Disease and Therapy
- Antibiotic Resistance in Bacteria
- Mechanical and Optical Resonators
- Laser-Matter Interactions and Applications
- Mitochondrial Function and Pathology
- Ubiquitin and proteasome pathways
- Advanced Thermodynamics and Statistical Mechanics
- Bacterial Genetics and Biotechnology
- ATP Synthase and ATPases Research
- Organic and Molecular Conductors Research
- S100 Proteins and Annexins
- Chronic Lymphocytic Leukemia Research
- Quantum Information and Cryptography
- Reconstructive Surgery and Microvascular Techniques
- Nitric Oxide and Endothelin Effects
- Neuroblastoma Research and Treatments
- Optical properties and cooling technologies in crystalline materials
Kyushu University
2013-2024
Kyushu University Hospital
2021-2024
Yamaguchi University
1980-2012
Nara Institute of Science and Technology
2000-2005
St. Marianna University School of Medicine
1992-1996
Osaka City University
1993
Columbia University
1990-1991
Tohoku University
1971-1987
Kure Medical Center
1970-1971
In cultured cells, not many mitochondria are degraded by mitophagy induced physiological cellular stress. We observed in HeLa cells using a method that relies on the pH-sensitive fluorescent protein Keima. With this approach, we found was barely carbonyl cyanide m-chlorophenyl hydrazone treatment, which is widely used as an inducer of PARK2/Parkin-related mitophagy, whereas small but modest amount were under conditions starvation or hypoxia. Mitophagy hypoxia marginally suppressed knockdown...
When mitophagy is induced in Saccharomyces cerevisiae, the mitochondrial outer membrane protein ScAtg32 interacts with cytosolic adaptor ScAtg11. ScAtg11 then delivers mitochondria to pre-autophagosomal structure for autophagic degradation. Despite importance of mitophagy, expression and functional regulation are poorly understood. In this study, we identified characterized homolog Pichia pastoris (PpAtg32). Interestingly, found that PpAtg32 was barely expressed before induction rapidly...
Abstract Human ATP-dependent Lon protease (LONP1) forms homohexameric, ring-shaped complexes. Depletion of LONP1 causes aggregation a broad range proteins in the mitochondrial matrix and decreases levels their soluble forms. The ATP hydrolysis activity, but not is critical for its chaperone-like anti-aggregation activity. complex with import machinery an incoming protein, protein linked import. also contributes to degradation imported, aberrant, unprocessed using Taken together, our results...
Abstract In gram-negative bacteria, IS 26 often exists in multidrug resistance (MDR) regions, forming a pseudocompound transposon (PCTn) that can be tandemly amplified. It also generates circular intermediate called the “translocatable unit (TU)”, but TU has been detected only by PCR. Here, we demonstrate Klebsiella pneumoniae MDR clone, mono- and multimeric forms of were generated from PCTn preexisting plasmid where inserted form was The two modes amplification reproduced culturing original...
ClpXP is the major protease in mitochondrial matrix eukaryotes, and well conserved among species. composed of a proteolytic subunit, ClpP, chaperone-like ClpX. Although it has been proposed that required for unfolded protein response, additional roles biogenesis are unclear. Here, we found Drosophila leucine-rich pentatricopeptide repeat domain-containing 1 (DmLRPPRC1) specific substrate ClpXP. Depletion or introduction catalytically inactive mutation ClpP increases DmLRPPRC1 causes...
We consider the relaxation dynamics of a spin-1/2 particle in fluctuating transverse magnetic field. With cumulant expansion technique (up to sixth order) we calculate time dependence approach equilibrium population difference two spin levels and phase coherence. find that for intermediate strength coupling fluctuations, converges, can have pronounced non-Markovian character. compare these analytic results with numerically exact data from stochastic simulations.
Most biological functions controlled by the brain and their related disorders are closely associated with activation in specific regions of brain. Neuroproteomics has been applied to analysis whole brain, general pattern protein expression all elucidated. However, comprehensive proteome each region remains unclear.In this study, we carried out comparative proteomics six adult rat brain: thalamus, hippocampus, frontal cortex, parietal occipital amygdala using semi-quantitative Mascot Score...
Five blaCTX-M-14-positive Klebsiella pneumoniae isolates (KpWEA1, KpWEA2, KpWEA3, KpWEA4-1, and KpWEA4-2) were consecutively obtained from a patient with relapsed acute myeloid leukemia who was continuously administered antimicrobials. Compared KpWEA1 KpWEA3 showed decreased susceptibility to antimicrobials, KpWEA4-1 KpWEA4-2 (isolated single specimen) further-elevated multidrug-resistance (MDR) phenotypes. This study aims clarify the clonality of five their evolutionary processes leading...
We present a unified theory for the luminescence spectra in highly excited semiconductors, which is applicable throughout whole density regime including electron-hole $(e\ensuremath{-}h)$ BCS state and excitonic Bose-Einstein condensate. The calculated clearly show crossover behavior between $e\ensuremath{-}h$ analysis based on generalized random-phase approximation combined with Bethe-Salpeter equation. This approach allows us to consider strong weak pair correlations same basis. In...
An analytical study of the photon echoes associated with three-level system interacting resonantly optical pulses possessing two different frequencies is performed. It predicted that arise at anomalous times corresponding to correlation between inhomogeneous broadenings for spectral lines as well normal time expected in a simple two-level system. This new effect caused by coupling resonant transitions through common energy level. Furthermore, if particle does not have inversion symmetry, sum...
An electron-hole system in a direct-gap semiconductor that is coherently excited by high-intensity laser investigated. The stationary state of the presence field described Bogolyubov quasiparticles. Using mean-field approximation, we derive set basic equations including electron-electron, hole-hole, and screened Coulomb interactions. screening effects are incorporated self-consistently on basis quasistatic random-phase approximation. has fixed chemical potential controlled frequency field....
A patient repeatedly developed bacteraemia despite the continuous use of antibiotics. We obtained two Klebsiella pneumoniae isolates from patient's blood on Days 72 and 105 after hospitalization. Each belonged to ST45, but while first isolate was susceptible most antibiotics, second one resistant multiple drugs including carbapenems.To identify genetic differences between uncover alterations formed by within-host bacterial evolution leading antimicrobial resistance.Whole-genome comparison...
We report on the transient behavior of second-order optical process in picosecond time region mixed semiconducting crystals. Time-integrated spectra under resonant excitation below band gap exhibit ``Raman-like'' lines associated with localized excitons. However, time-resolved spectroscopy enabled us to resolve these Raman-like into luminescence and Raman scattering lines. have found transformation as a function incident frequencies without changing spectral shape. Furthermore, intensity...
We present a unified theory for pump-probe spectra in highly excited semiconductors, which is applicable throughout the whole density regime including high-density electron-hole BCS state and low-density excitonic Bose-Einstein condensate (BEC). The analysis based on BCS-like pairing combined with Bethe-Salpeter (BS) equation, first enables us to incorporate state-filling effect, band-gap renormalization strong/weak pair correlations manner. show that distinctly stabilized by intense...
The theoretical analysis on photon echoes is reported in a resonant multi-level system with level degeneracy, by general consideration. With respect to the possessing more than three-fold intensity of depends not only areas exciting optical pulses, but also their polarization characteristics. In particular, it was found that some anomalous change intensities directions pulses which have different frequencies from those because coherent coupling transitions common energy and interference...
We study the infrared absorption of macroscopic quantum state in highly excited semiconductors. The calculated spectrum clearly shows BCS-like energy-gap (BEG) formation. incorporate large fluctuation with quasistatic Eliashberg equation for e-h systems that allows us to calculate renormalized band energy, BEG, and wave function renormalization factor. find collective phase significantly modifies spectra, strong visible-light excitation distinctly stabilizes $e\ensuremath{-}h$ BCS state.