A5105350671- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Mesenchymal stem cell research
- Cardiac Valve Diseases and Treatments
- Lung Cancer Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
- Cardiac and Coronary Surgery Techniques
- Tissue Engineering and Regenerative Medicine
- Lymphatic System and Diseases
- Cardiac Structural Anomalies and Repair
- Transplantation: Methods and Outcomes
- Cardiac, Anesthesia and Surgical Outcomes
- Angiogenesis and VEGF in Cancer
- Cardiac Ischemia and Reperfusion
- Venous Thromboembolism Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Infectious Aortic and Vascular Conditions
- Pleural and Pulmonary Diseases
- Electrospun Nanofibers in Biomedical Applications
- Infective Endocarditis Diagnosis and Management
- Tracheal and airway disorders
- Gastrointestinal disorders and treatments
- Diverticular Disease and Complications
- Mechanical Circulatory Support Devices
- Vascular Procedures and Complications
Yamaguchi University
2016-2025
Saiseikai Shimonoseki General Hospital
2024
Graduate School USA
2023
San Diego Cardiac Center
2020
Suzuki (Japan)
2020
Ihara Chemical Industry (Japan)
2019
National Rehabilitation Center for Persons with Disabilities
2016
Yamaguchi Prefectural University
2016
Japan Fisheries Research and Education Agency
1994-2014
Social Insurance Saitama Chuo Hospital
2014
A new therapy for severe ischemic heart disease has been developed; therapeutic angiogenesis induced by the local implantation of autologous bone marrow cells (BMC). After confirming that no detrimental changes were this treatment in a canine model, clinical trial was commenced 1999. Thus far, 5 patients have given concomitant with coronary artery bypass grafting and all followed up at least 1 year. Autologous BMC implanted into ungraftable area postoperative cardiac scintigraphy showed...
It is well known that the implantation of bone marrow mononuclear cells (BM-MNCs) into ischemic hearts can induce angiogenesis and improve cardiac function after myocardial infarction, but precise mechanisms these actions are unclear. We hypothesize cytokines produced by BM-MNCs play a key role in this cell-based therapy. from rats were cultured under normoxic or hypoxic (1% O2) conditions for 24 h, then supernatants collected study. ELISA Western blotting analysis showed various cytokines,...
Objective: This study aimed to evaluate the effect of inferior mesenteric artery (IMA) embolization during endovascular aneurysm repair (EVAR) in patients at high risk type II endoleak (T2EL) randomized controlled trial (RCT). Summary Background Data: Several studies have demonstrated a reduction T2EL by IMA before EVAR. However, there been no RCT confirming efficacy embolization. Methods: Patients scheduled for elective EVAR between April 2014 and March 2018 were eligible. (IMA patency with...
Recent studies have shown that bone marrow-derived stem cells differentiate into the phenotype of cardiomyocytes in vivo and vitro. We tried to regenerate infarcted myocardium by implanting ex transforming growth factor (TGF)-beta-preprogrammed CD117 (c-kit)-positive (CD117+) intramyocardially.CD117+ were isolated from marrow mononuclear GFP-transgenic or normal C57/BL6 mice. The myogenic differentiation CD117+ was achieved cultivation with TGF-beta. Using an acute myocardial infarction...
The prognosis of patients with pancreatic cancer is very poor because late diagnosis and the lack response to various therapies. We tried identify proteins that might be available for early effective therapies by proteomic profiling tissues. Pancreatic cancerous paired non-cancerous tissues obtained from surgical resections or autopsies 10 were analyzed two-dimensional gel electrophoresis. differential display showed 11 spots whose expression was increased in compared liquid...
To clarify whether ultrasound findings of skin and subcutaneous tissue represent the severity lymphedema.Thirty-five patients with secondary lower extremity lymphedema caused by intrapelvic lymph node dissection during cancer surgery, who first visited our clinic between April 2009 March 2012, were studied retrospectively. At their visit, thickness, echogenicity assessed at 8 points on thigh leg both legs using an 11-MHz transducer. These correlated International Society Lymphology (ISL)...
To elucidate the differences in subcutaneous ultrasound findings between dependent edema (DE) and secondary lower extremity lymphedema (LE).Twenty legs 10 patients with DE 54 35 LE, who first visited our clinic April 2009 December 2012, were studied retrospectively. Subcutaneous echogenicity echo-free space (EFS) assessed at 8 points on thigh leg using an 8-12 MHz transducer.In DE, was increased most leg, without a difference medial lateral side. The EFS remarkable side more severe. In early...
The source of donor alloantigen required to maintain tolerance in vivo was evaluated anti-Cd4 monoclonal antibody (mAb) treated mice. Treatment with a depleting mAb at the time transplantation (day-1, 0) induces C57BL/10 (H2b)vascularized cardiac allografts C3H.He (H2k)mice(1). presence vascularized allograft found be essential for induction this experimental model; it is only during phase unresponsiveness (0-50 days). In maintenance (>50 days) potentially available from two sources, organ...
Therapeutic angiogenesis can be induced by the implantation of bone marrow mononuclear cells. We investigated roles mature cell and stem fractions in this treatment. Although CD34 is most popular marker for selection inducing therapeutic angiogenesis, we separated CD117-positive cells (CD117 + ) from [CD117-negative – )] mice using antibody to receptor, because some that express CD117 might generate angiogenic cytokines differentiate into endothelial The potency was vitro vivo. Significantly...
Neovascularization has recently been used as a new treatment for severe ischemic disease. We tried to induce therapeutic neovascularization by autologous bone marrow cell implantation (BMCI) in eight selected patients with chronic peripheral arterial disease (PAD), whom traditional treatments had failed. Improvement of subjective symptoms was seen seven after treatment. Of three limbs toe or finger ulceration, complete healing achieved two, while the other one became less No relative...
Aims Abdominal aortic aneurysms (AAAs) are characterized by chronic inflammation, which contributes to the pathological remodeling of extracellular matrix. Although mechanical stress has been suggested promote inflammation in AAA, molecular mechanism remains uncertain. Periostin is a matricellular protein known respond strain. The aim this study was elucidate role periostin mechanotransduction pathogenesis AAA. Methods and Results We found significant increases levels walls human AAA...
HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors (statins) have been suggested to attenuate abdominal aortic aneurysm (AAA) growth. However, the effects of statins in human AAA tissues are not fully elucidated. The aim this study was investigate direct on proinflammatory molecules walls ex vivo culture. Simvastatin strongly inhibited activation nuclear factor (NF)-κB induced by tumor necrosis (TNF)-α walls, but showed little effect c-jun N-terminal kinase (JNK)...
Abstract c‐ MYC overexpression is frequently observed in various cancers including colon cancer and regulates many biological activities such as aberrant cell proliferation, apoptosis, genomic instability, immortalization drug resistance. However, the mechanism by which confers resistance remains to be fully elucidated. In this study, we found that expression level primary colorectal tissues correlated with recurrence rate following 5‐fluorouracil (5‐ FU )‐based adjuvant chemotherapy....
Background Saphenous vein grafts (SVGs) are broadly used in coronary artery bypass grafting despite their inferior patency compared with arterial grafts. Recently, the no-touch technique (NT), which an SVG is harvested a pedicle of perivascular adipose tissue (PVAT) without conduit distension, was shown to improve long-term conventional preparation (CV), wherein outer removed distension. The NT also reportedly associated reduced atherosclerosis. Although endothelial damage provoked by...
Objectives The present multicenter prospective observational study investigated the effectiveness and safety of neoadjuvant chemotherapy (NAC) for patients with borderline resectable pancreatic cancer (BRPC) those RPC contacting major vessels, respect to a historical control upfront surgery. Materials Methods Patients BRPC vessels were prospectively registered administered NAC durations regimens determined by corresponding treating physician. Our primary aim was assess R0 resection rate,...
Bone marrow contains various primitive cells that are thought to secrete several angiogenic growth factors and may also differentiate into endothelial cells. The present study was conducted investigate the possibility bone could be a novel material induce angiogenesis. expression of vascular factor (VEGF) basic fibroblast (bFGF) in rat examined by immunohistochemistry. production VEGF compared tissue culture supernatant under conditions normoxia hypoxia. process angiogenesis occurred...
Therapeutic angiogenesis can be induced by local implantation of bone marrow cells. We tried to enhance the angiogenic potential this treatment ex vivo hypoxia stimulation cells before implantation. Bone were collected and cultured at 33°C under 2% O 2 -5% CO -90% N (hypoxia) or 95% air-5% (normoxia). Cells also injected into ischemic hindlimb rats after 24 h culture. Hypoxia culture increased mRNA expression vascular endothelial growth factor (VEGF), (VE)-cadherin, fetal liver kinase-1...
Abstract Purpose: Because both emphysema and lung cancer can arise from biological damage caused by cigarette smoking, we investigated if the development of is associated with clinical features smoker's cancer. Experimental Design: The subjects were a consecutive series 100 smokers who underwent lobectomy hilar mediastinal dissection for stage I non–small cell We studied relationship between presence or absence at onset clinicopathologic features. Emphysema was diagnosed measuring...