A5015671899- Amyloidosis: Diagnosis, Treatment, Outcomes
- Alzheimer's disease research and treatments
- Neuroendocrine Tumor Research Advances
- Drug Transport and Resistance Mechanisms
- Dermatological and Skeletal Disorders
- Parathyroid Disorders and Treatments
- Prion Diseases and Protein Misfolding
- Sarcoidosis and Beryllium Toxicity Research
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Chronic Lymphocytic Leukemia Research
- Trace Elements in Health
- Medical Imaging and Pathology Studies
- Gastrointestinal Tumor Research and Treatment
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Urinary and Genital Oncology Studies
- Pancreatitis Pathology and Treatment
- Skin and Cellular Biology Research
- Protein Kinase Regulation and GTPase Signaling
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Immunotherapy and Biomarkers
- IgG4-Related and Inflammatory Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Multiple Myeloma Research and Treatments
Yamaguchi University
2009-2024
Yamaguchi University Hospital
2014-2024
Aichi Medical University
2024
Ikeda Municipal Hospital
2006
Shinshu University
1997-2006
Nagoya University
2006
Shizuoka Red Cross Hospital
2004
Yamaguchi Prefecture Central Hospital
1998
Tokuyama (Japan)
1998
Kumamoto University
1998
Dedifferentiation has been implicated in β cell dysfunction and loss rodent diabetes. However, the pathophysiological significance humans remains unclear. To elucidate this, we analyzed surgically resected pancreatic tissues of 26 Japanese subjects with diabetes 11 nondiabetic subjects, who had overweight during adulthood but no family history The diabetic were subclassified into 3 disease stage categories, early, advanced, intermediate. Despite numerical changes endocrine cells...
// Nakanori Fujii 1 , Hiroshi Hirata 1, 2 Koji Ueno 3 Junichi Mori Shintaro Oka Kosuke Shimizu Yoshihisa Kawai Ryo Inoue Yoshiaki Yamamoto Hiroaki Matsumoto Tomoyuki Shimabukuro 4 Koichi Udoh 5 Yoshinobu Hoshii 6 Rajvir Dahiya 7 and Hideyasu Matsuyama Department of Urology, Graduate School Medicine, Yamaguchi University, Ube, 755-8505, Japan Ube Memorial Hospital, 755-0051, Center for Regenerative University Kosan Central 755-0151, Institute Biomedical Research Education, Science Center,...
In 2019, 2020 and 2022, the Japanese Government approved use of tafamidis two technetium-scintigraphies for transthyretin amyloid (ATTR) cardiomyopathy, announced patient criteria therapy. 2018, we had started a nation-wide pathology consultation amyloidosis.To reveal impact approval technetium-scintigraphy on diagnosis ATTR cardiomyopathy.Ten institutes participated in this study amyloidosis shared rabbit polyclonal anti-κ116-133, anti-λ118-134, anti-transthyretin115-124 antibodies....
Abstract Most intractable tissue‐degenerative disorders share a common pathogenic condition, so‐called proteinopathy. Amyloid‐related are the most proteinopathies and characterized by amyloid fibril deposits in brain or other organs. Aging is generally associated with development of these amyloid‐related disorders, but we still do not fully understand how functional proteins become during human aging process. We identified novel amyloidogenic protein, named epidermal growth factor‐containing...
For the immunohistochemical detection of immunoglobulin (Ig) light chain amyloidosis on formalin‐fixed, paraffin‐embedded tissue sections, we prepared polyclonal antibodies against synthetic peptides corresponding to positions 118–134 Ig λ and 116–133 κ chain. Nineteen cases systemic (Aλ amyloidosis), 10 (Aκ one case immunohistochemically unclassified five localized Aλ were tested with these antibodies. Anti‐λ (118–134) antiserum affinity‐purified antibody both reacted 18 19 all amyloidosis,...
Familial amyloid polyneuropathy (FAP) is a form of hereditary generalized amyloidosis. Liver tissue explanted from FAP patients has normal structure and function, except for the production amyloidogenic variant transthyretin (TTR), domino liver transplantation (DLT) using grafts was first performed in 1995. symptoms usually develop genetically determined individuals after age 20, but it difficult to estimate when will appear recipients. Concerning this problem, histological findings showing...
Senile plaques In the brains of Alzheimer's disease (AD) were examined by confocal laser scanning microscopy (CLSM) with following three findings. First, in sections stained Congo red, serial CLSM images optical clearly revealed that a classic plaque is composed core and corona. Radially arranged process‐like structures, corresponding to bundles amyloid fibrils, formed cores stronger signals detected center some cores. Second, red anti‐gllal fibrillary acidic protein (GFAP), reactive...
One hundred and forty autopsy cases of systemic amyloidosis were examined using the potassium permanganate method for distinction amyloid A protein from other proteins an immunohistochemical technique. Of those cases, identified in 121 cases. There 68 A-related (AA) these most common type among (56.2%). 39 immunoglobulin light chain-related (AL) (32.2%), six beta 2-microglobulin-related (A 2M) (5%), five transthyretin-related (ATTR) (4.1%). Minute areas deposits four with AA resistant to...
Acceleration of amyloid deposition by administration fibrils and transmissibility disease have been reported for several types amyloidosis. Reactive amyloidosis (AA) occurs in a wide variety domestic animal species is characterized mainly spleen, liver, kidneys. Because the visceral organs animals traditionally used Asian cuisines, it important to examine whether dietary ingestion themselves (rather than purified fibrils) accelerates AA deposition. Herein, we show that murine develops...
We herein report that experimental murine amyloid A (AA) deposition is accelerated by oral administration of semipurified fibrils extracted from different species. Three groups mice were treated with AA fibrils, bovine or human light chain‐derived (A λ ) for 10 days. After 3 weeks, each mouse was subjected to inflammatory stimulation subcutaneous injection a mixture complete Freund’s adjuvant supplemented Mycobacterium butyricum . The killed on the third day after stimulation, and spleen,...
Abstract We investigated amyloid‐enhancing factor (AEF) activity of amyloid fibrils extracted from amyloid‐laden livers mice, cow, cheetah, cat and swan. All were confirmed to be protein A (AA) by an immunohistochemical analysis. found that these accelerated the deposition in experimental mouse model AA amyloidosis. Furthermore, degree was dependent on concentration fibrils. When we compared minimal needed induce deposition, showed different efficiencies. Murine fibril induced more...
Patients with AL amyloidosis were treated VAD (vincristine, doxorubicin and dexamethasone) or without high-dose melphalan followed by auto-PBSCT according to eligibility criteria based on disease severity, prospectively investigated the therapeutic benefits complications. Thirty-one patients enrolled in this study. subsequent performed only who met all of criteria. Among ineligible for treatment, alone was those satisfactory general status. Eleven criteria, these, 7 auto-PBSCT. Seven...
Experimental mouse AA amyloidosis can be transmissible by dietary ingestion of amyloid fibrils and it is well known that occasionally develops in aged cattle. Bovine liver intestine have conventionally been used Oriental foods, the incidence visceral slaughtered cattle was evaluated. Renal tissues from 302 older than 4 years were obtained a local abattoir. Amyloid deposition microscopically examined protein immunochemically determined. seen 15 out with no previous history diseas, an 5.0%....
Cancer immunotherapy, including vaccination, is considered a major scientific and medical breakthrough. However, cancer immunotherapy does not result in durable objective responses against colorectal cancer (CRC). To improve the efficacy of present study investigated several biomarkers for selecting patients who were expected to respond well immunotherapy. Firstly, comprehensive proteomic analysis was performed using tumor tissue lysates from enrolled phase II study, which five human...
A 74-year-old woman who had developed numbness in both hands was diagnosed as having bilateral carpal and right cubital tunnel syndrome underwent release. Transthyretin immunoreactive amyloid deposits were seen on specimens also detected gastric, duodenal ileal mucosal biopsies. The transthyretin gene analysis showed no mutation. This is a rare case of senile systemic amyloidosis presenting syndrome.