A5102953151- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Retinal Development and Disorders
- Cardiomyopathy and Myosin Studies
- Cardiac pacing and defibrillation studies
- CRISPR and Genetic Engineering
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Sarcoidosis and Beryllium Toxicity Research
- ECG Monitoring and Analysis
- Cardiovascular Function and Risk Factors
- Single-cell and spatial transcriptomics
- Cardiovascular Effects of Exercise
- Systemic Sclerosis and Related Diseases
- Receptor Mechanisms and Signaling
- Phytochemicals and Antioxidant Activities
- Cardiac Ischemia and Reperfusion
- SARS-CoV-2 and COVID-19 Research
- Pulmonary Hypertension Research and Treatments
- Molecular Biology Techniques and Applications
- Infective Endocarditis Diagnosis and Management
- Retinal Diseases and Treatments
- Chemotherapy-related skin toxicity
- Erythrocyte Function and Pathophysiology
Yamaguchi University
2015-2025
Palette (Canada)
2023-2024
Yamaguchi University Hospital
2023
Fukuda Denshi (Japan)
2012-2022
Sapporo Medical University
2021
Boston Biomedical Research Institute
2011
Harvard University
2011
Yamaguchi Prefecture Central Hospital
2010
Sysmex (Japan)
1997
Tokyo Metropolitan Kiyose Children's Hospital
1994
The molecular mechanism by which catecholaminergic polymorphic ventricular tachycardia is induced single amino acid mutations within the cardiac ryanodine receptor (RyR2) remains elusive. In present study, we investigated mutation-induced conformational defects of RyR2 using a knockin mouse model expressing human tachycardia-associated mutant (S2246L; serine to leucine mutation at residue 2246).All mice examined produced after exercise on treadmill. cAMP-dependent increase in frequency Ca²⁺...
The variant in SCN5A with the loss of function (LOF) effect cardiac Na+ channel (Nav1.5) is definitive cause for Brugada syndrome (BrS), and functional analysis data revealed that LOF variants are associated poor prognosis. However, which types (e.g. missense or non-missense) affect prognoses those carriers remain unelucidated. We defined as all non-missense produce peak INa < 65% wild-type previously confirmed by patch-clamp studies. study population consisted 76 Japanese BrS patients (74%...
Background Pre-procedural and post-procedural plasma B-type natriuretic peptide (BNP) levels can predict rhythm outcomes after catheter ablation for atrial fibrillation (AF). However, the significance of long-term events remains unclear. Therefore, this study aimed to investigate integrating pre-ablation post-ablation BNP on major adverse cardiovascular (MACE) arrhythmic recurrence in patients with persistent AF undergoing ablation. Methods We analysed 392 who underwent first Patients were...
AimsThe channel function of the cardiac ryanodine receptor (RyR2) is modulated by calmodulin (CaM). However, involvement CaM in aberrant Ca2+ release diseased hearts remains unclear. Here, we investigated pathogenic role defective binding to RyR2 dysfunction associated with heart failure.
Abstract Aims Data regarding prognostic events following catheter ablation (CA) for atrial fibrillation (AF) in patients with heart failure preserved ejection fraction (HFpEF) are scarce. We conducted this study to compare the incidence of major adverse clinical (MACE) CA AF between HFpEF and those systolic (HF). Methods results This single‐centre observational included 142 HF who underwent (median follow‐up: 4.0 [2.6, 6.3] years). The were grouped based on presence ( n = 84) (left...
Objectives The purpose of this study was to investigate whether adding a low-dose β1-blocker milrinone improves cardiac function in failing cardiomyocytes and the underlying cardioprotective mechanism. Background molecular mechanism how combination affects intracellular Ca2+ handling heart failure remains unclear. Methods We investigated effect plus landiolol on transient (CaT), cell shortening (CS), frequency diastolic sparks (CaSF), sarcoplasmic reticulum concentration ({Ca2+}SR) normal...
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart disease that causes failure and/or sudden cardiac death. Several desmosomal genes (DSC2, PKG, PKP2, DSP, and RyR2) are thought to be the causative gene involved in ARVC. Out of them, DSC2 mutations account for 2% ARVC genetic abnormalities. This study aimed clarify effect G790del mutation on arrhythmogenic mechanism function a mouse model. Neither heterozygous +/G790del nor homozygous G790del/G790del mice showed...
Sudden cardiac death (SCD) is the major cause of in sarcoidosis (CS). We aimed to identify prognostic markers for sustained ventricular tachycardia (sVT) and SCD patients with CS.
Retinal pigment epithelium (RPE) cells show heterogeneous levels of pigmentation when cultured in vitro. To know whether their color appearance is correlated with the function RPE, we analyzed intensities human-induced pluripotent stem cell-derived RPE (iPSC-RPE) together gene expression profile at single-cell level. For this purpose, utilized our recent invention, Automated Live imaging and cell Picking System (ALPS), which enabled photographing each before RNA-sequencing analysis to cell....
The relationship between changes in the left atrial volume index (LAVI) post-catheter ablation (CA) and long-term prognostic events patients with persistent fibrillation (AF) remains unclear. We evaluated incidence of major adverse clinical (MACE), including all-cause death, unplanned heart failure hospitalization, cardiovascular hospitalization using pre- post-CA LAVI.
Background: Tachycardia worsens cardiac performance in acute decompensated heart failure (ADHF). We investigated whether rate (HR) optimization by landiolol, an ultra-short-acting β1-selective blocker, combination with milrinone improved function patients ADHF and rapid atrial fibrillation (AF). Methods Results: enrolled9 (New York Heart Association classification IV; HR, 138 ± 18 bpm; left ventricular [LV] ejection fraction, 28 8%; index [CI], 2.1 0.3 L/min–1/m–2; pulmonary capillary wedge...
Abstract Background Remimazolam is a benzodiazepine receptor agonist with an ultra-short-acting anesthetic effect. We used remimazolam for anesthesia in patient myotonic dystrophy type 1 who underwent endoscopic retrograde cholangiopancreatography (ERCP). Case presentation A 58-year-old woman received ERCP under general anesthesia. She had impaired respiratory function due to I and was at risk of complications after General induced 12 mg/kg/h, remifentanil 0.1 μg/kg/min rocuronium 15 mg,...
Background Catheter ablation can improve long-term prognosis of patients with atrial fibrillation systolic impairment. However, tachyarrhythmia (ATA) recurrence increases during follow-up. We aimed to investigate the impact ATA on development adverse clinical events following catheter for and identify predictors events. Methods Results This single-center observational study included 75 impairment (left ventricular ejection fraction <50%) who underwent first procedure at our institution...
Retinal pigment epithelium (RPE) cells show heterogeneous levels of pigmentation when cultured in vitro. To know whether their color appearance is correlated with the function RPE, we analyzed intensities human-induced pluripotent stem cell-derived RPE (iPSC-RPE) together gene expression profile at single-cell level. For this purpose, utilized our recent invention, Automated Live imaging and cell Picking System (ALPS), which enabled photographing each before RNA-sequencing analysis to cell....