A5100346554- MicroRNA in disease regulation
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Traditional Chinese Medicine Analysis
- NF-κB Signaling Pathways
- Metabolomics and Mass Spectrometry Studies
- Mitochondrial Function and Pathology
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Studies
- Cell death mechanisms and regulation
- Heat shock proteins research
- Ubiquitin and proteasome pathways
- Pluripotent Stem Cells Research
- Pelvic floor disorders treatments
- Extracellular vesicles in disease
- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Mesenchymal stem cell research
- Cytokine Signaling Pathways and Interactions
- Chemotherapy-induced organ toxicity mitigation
- Wound Healing and Treatments
- Pharmacological Effects of Natural Compounds
- Immune Response and Inflammation
Guangdong Pharmaceutical University
2022-2024
Wuhan University
2014-2024
Renmin Hospital of Wuhan University
2023-2024
Van Andel Institute
2020-2024
Capital Medical University
2019-2024
Shanghai University of Traditional Chinese Medicine
2024
Seventh People's Hospital of Shanghai
2024
Baoding People's Hospital
2024
Beijing Children’s Hospital
2024
First Affiliated Hospital of Hebei Medical University
2024
Abstract Background Recent research increasingly highlights a strong correlation between gut microbiota and the risk of gastrointestinal diseases. However, whether this relationship is causal or merely coincidental remains uncertain. To address this, Mendelian randomization (MR) analysis was undertaken to explore connections prevalent Methods Genome-wide association study (GWAS) summary statistics for microbiota, encompassing diverse range 211 taxa (131 genera, 35 families, 20 orders, 16...
Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that plays an important role in the expression of genes, whose function exerted through protein–protein interactions (PPIs), such as transcriptional co-activator (CREB)-binding protein (CBP) and p300. Under hypoxic conditions, HIF-1is stabilized translocated to CBP or p300, leading response cascade. Furthermore, PPI between HIF p300/CBP potential cancer target for their response. In this study, molecular dynamics (MD) simulation...
Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders and a leading cause subfertility. The mechanism underlying pathophysiology PCOS remains to be illustrated. Here, we identify two alternative splice variants (ASVs) androgen receptor (AR), insertion deletion isoforms, in granulosa cells (GCs) ∼62% patients with PCOS. AR ASVs are strongly associated remarkable hyperandrogenism abnormalities folliculogenesis, absent from all control subjects without...
Polycystic ovary syndrome (PCOS), whose etiology remains uncertain, is a highly heterogenous and genetically complex endocrine disorder. The aim of this study was to identify differentially expressed genes (DEGs) in granulosa cells (GCs) from PCOS patients make epigenetic insights into the pathogenesis PCOS. Included were 110 women with 119 normal ovulatory cycles undergoing vitro fertilization acting as control group. RNA-seq identified 92 DEGs unique GCs comparison Bioinformatic analysis...
Abstract Colonocyte metabolism shapes the microbiome. Metabolites are main mediators of information exchange between intestine and microbial communities. Arachidonic acid (AA) is an essential polyunsaturated fatty its role in colorectal cancer (CRC) remains unexplored. In this study, we show that AA feeding promotes tumor growth AOM/DSS intestinal specific Apc −/− mice via modulating microecology increased gram-negative bacteria. Delta-5 desaturase (FADS1), a rate-limiting enzyme,...
Summary The mitogen‐activated protein kinase ( MAPK ) signaling pathways have been characterized in Fusarium graminearum . Currently, the upstream sensors of these are unknown. Biological functions a transmembrane FgSho1 were investigated using target gene deletion strategy. relationship between and cassette FgSte50‐Ste11‐Ste7 was analyzed depth. is required for conidiation, full virulence, deoxynivalenol DON biosynthesis F. Furthermore, FgSln1 an additive effect on virulence yeast...
An unprecedented and efficient organic base-catalysed highly chemoselective carbo- oxytrifluoromethylation of unactivated alkenes with Togni's reagent was developed.
Background: Colorectal cancer (CRC) is one of the leading causes cancer-related deaths worldwide. Although chemotherapy primary means in colorectal treatment, it burdenerd by adverse drug effects. Drug-resistance most important challenges for and epithelial-mesenchymal transition (EMT) plays critical role development resistance. Aims: The aim this study was to investigate mechanisms underlying effect astragaloside IV (AS-IV) on miR-134 expression, EMT chemotherapeutic sensitivity CRC....
Abstract The process of vascular remodeling is associated with increased hypoxia. However, the contribution hypoxia-inducible factor 1α (HIF1α), key transcription mediating cellular hypoxic responses, to established, but not completely understood. In angiotensin II (Ang II)-induced model, HIF1α was and activated in smooth muscle cells (VSMCs). Selective genetic disruption Hif1a VSMCs markedly ameliorated Ang II-induced remodeling, as revealed by decreased blood pressure, aortic thickness,...
VEGFA and TGF-β are known major angiogenic fibrogenic factors. Galectin-1, encoded by lectin, galactoside-binding, soluble (LGALS)1, has attracted growing attention for its facilitatory role in angiogenesis fibrosis through modification of receptor signaling pathways. We reveal galectin-1 involvement the mouse model laser-induced choroidal neovascularization (CNV) subretinal fibrosis, both which represent pathogenesis age-related macular degeneration (AMD). Neither deletion nor...
Women experience osteoporosis at higher rates than men. Aside from hormones, the mechanisms driving sex-dependent bone mass regulation are not well understood. Here, we demonstrate that X-linked H3K4me2/3 demethylase KDM5C regulates sex-specific mass. Loss of in hematopoietic stem cells or marrow monocytes increases female but male mice. Mechanistically, loss impairs bioenergetic metabolism, resulting impaired osteoclastogenesis. Treatment with KDM5 inhibitor reduces osteoclastogenesis and...
Bone defects resulting from severe trauma, tumors, inflammation, and other factors are increasingly prevalent. Stem cell-based therapies have emerged as a promising alternative. Dental pulp stem cells (DPSCs), sourced dental pulp, garnered significant attention owing to their ready accessibility minimal collection-associated risks. Ongoing investigations into DPSCs revealed potential undergo osteogenic differentiation capacity secrete diverse array of ontogenetic components, such...
The Hsp70 family protein mortalin is an essential chaperone that frequently enriched in cancer cells and exists various subcellular sites, including the mitochondrion, plasma membrane, endoplasmic reticulum, cytosol. Although molecular mechanisms underlying its multiple localizations are not yet clear, their functional significance has been revealed by several studies. In this study, we examined nuclear fractions of human found malignantly transformed have more than normal cells. We then...
Accumulating evidence from clinical and epidemiological studies has highlighted the close correlation between individual risk of cancer nervous system diseases. The expression neuronal pentraxin 2 (NPTX2) is absent in Alzheimer's disease, anxiety, depression. Herein, we found that NPTX2 mRNA protein was significantly upregulated colorectal carcinoma (CRC). level gradually increased with CRC progression closely associated poor prognosis. In vitro vivo demonstrated promoted proliferation...
Continual Test-Time Adaptation (CTTA) aims to adapt models sequentially changing domains during testing, relying on pseudo-labels for self-adaptation. However, incorrect can accumulate, leading performance degradation. To address this, we propose a Conformal Uncertainty Indicator (CUI) CTTA, leveraging Prediction (CP) generate prediction sets that include the true label with specified coverage probability. Since domain shifts lower than expected, making CP unreliable, dynamically compensate...
Urinary incontinence, often perceived as embarrassing, perpetuates the stigma that delays treatment and encourages concealment. This significantly diminishes quality of life imposes both financial medical burdens. Although prior research has examined reduction in urinary it persists a widespread issue. Most studies have focused on interviews, primarily addressing urine leakage, with limited understanding factors influencing incontinence their interrelations. More in-depth quantitative are...