A5009970282- COVID-19 diagnosis using AI
- Nerve injury and regeneration
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Artificial Intelligence in Healthcare
- COVID-19 Clinical Research Studies
- Hair Growth and Disorders
- Virus-based gene therapy research
- Viral-associated cancers and disorders
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Pneumocystis jirovecii pneumonia detection and treatment
- Moyamoya disease diagnosis and treatment
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Advancements in Transdermal Drug Delivery
- Curcumin's Biomedical Applications
- Pneumonia and Respiratory Infections
- Lymphoma Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Dermatologic Treatments and Research
- Adenosine and Purinergic Signaling
- Pluripotent Stem Cells Research
- Head and Neck Surgical Oncology
Wuhan University
2020-2025
Renmin Hospital of Wuhan University
2020-2025
Capital Medical University
2025
Spinal cord injury (SCI) is accompanied by loss of Zn2+, which an important cause glutamate excitotoxicity and death local neurons as well transplanted stem cells. Dental pulp cells (DPSCs) have the potential for neural differentiation play immunomodulatory role in microenvironment, making them ideal cell source repair central nerve injury, including SCI. The zeolitic imidazolate framework 8 (ZIF-8) usually used a drug gene delivery carrier, can release Zn2+ sustainedly acidic environment....
Bone defects resulting from severe trauma, tumors, inflammation, and other factors are increasingly prevalent. Stem cell-based therapies have emerged as a promising alternative. Dental pulp stem cells (DPSCs), sourced dental pulp, garnered significant attention owing to their ready accessibility minimal collection-associated risks. Ongoing investigations into DPSCs revealed potential undergo osteogenic differentiation capacity secrete diverse array of ontogenetic components, such...
Abstract Spinal cord injury (SCI) often results in motor and sensory deficits, or even paralysis. Due to the role of cascade reaction, effect excessive reactive oxygen species (ROS) early middle stages SCI severely damage neurons, most antioxidants cannot consistently eliminate ROS at non-toxic doses, which leads a huge compromise antioxidant treatment SCI. Selenium nanoparticles (SeNPs) have excellent scavenging bioactivity, but toxicity control problem limits therapeutic window. Here, we...
The outbreak of coronavirus disease 2019 (COVID-19) that occurred in Wuhan, China, has become a global public health threat. It is necessary to identify indicators can be used as optimal predictors for clinical outcomes COVID-19 patients.The information from 126 patients diagnosed with were collected Wuhan Fourth Hospital. Specific characteristics, laboratory findings, treatments and analyzed hospitalized treatment 1 February 15 March 2020, subsequently died or discharged. A random forest...
Spinal cord injury (SCI) is a traumatic disease that seriously damages the central nervous system, which will bring heavy burden to patients physically, mentally and economically. Ferroptosis newly discovered mode of cell death in recent years. It has been found ferroptosis related variety diseases (stroke, brain injury, neurodegenerative diseases, etc.), plays major role secondary after spinal injury. Ferrostatin-1 (Fer-1) potent inhibitor shown improve functional recovery SCI by...
Abstract Oxidative stress is increasingly recognized as a major contributor to the pathophysiology of Alzheimer’s disease (AD), particularly in early stages disease. The multiplicity advantages stem cell transplantation make it fascinating therapeutic strategy for many neurodegenerative diseases. We herein demonstrated that human dental pulp cells (hDPSCs) mediated oxidative improvement and neuroreparative effects vitro AD models, playing critical roles regulating polarization hyperreactive...
The Epstein-Barr virus (EBV) is involved in the carcinogenesis of gastric cancer (GC) upon infection normal cell and induces a highly variable composition tumour microenvironment (TME). However, systematic bioinformatics analysis key genes associated with EBV regulation immune infiltration still lacking. In present study, TCGA GEO databases were recruited to analyse association between profile GC. weighted gene co-expression (WGCNA) was applied shed light on modules EBV-associated 204 GC...
With the increasing understanding of mesenchymal stem cells (MSCs), their potential in tissue engineering and regenerative medicine has attracted more attention. However, some important problems need to be solved before clinical application, such as low amplification efficiency, inconsistent cell product quality, unsatisfactory survival rate at receptor site. Telomeres act a clock, they shorten when divide. The main mechanism for reversing telomere length is telomerase. Furthermore,...
Objective: To explore the clinical features, serotype distribution and drug resistance of isolates in patient with invasive pneumococcal disease (IPD). Methods: By retrieving laboratory information system 18 children's hospitals from 2012 to 2017, children IPD were enrolled. Streptococcus pneumoniae (Spn) must be isolated sterile sites (blood, cerebrospinal fluid, hydrothorax joint effusion etc.). The characteristics, serotype, resistance, treatment prognosis reviewed analyzed. According...
<title>Abstract</title> Spinal cord injury (SCI) often results in motor and sensory deficits, or even paralysis. Due to the role of cascade reaction, effect excessive reactive oxygen species (ROS) early middle stages SCI severely damage neurons, most antioxidants cannot consistently eliminate ROS at non-toxic doses, which leads a huge compromise antioxidant treatment SCI. Selenium nanoparticles (SeNPs) have excellent scavenging bioactivity, but toxicity control problem limits therapeutic...
Background: Disrupted hippocampal functions and progressive neuronal loss represent significant challenges in the treatment of Alzheimer's disease (AD). How to achieve improvement pathological progression effective neural regeneration ameliorate intracerebral dysfunctional environment cognitive impairment is goal current AD therapy. Methods: We examined therapeutic potential clinical-grade human derived dental pulp stem cells (hDPSCs) function neuropathology AD. Specifically, we investigated...