A5100440059- Monoclonal and Polyclonal Antibodies Research
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Retinal Imaging and Analysis
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Medical Imaging Techniques and Applications
- Multimodal Machine Learning Applications
- Effects of Radiation Exposure
- COVID-19 diagnosis using AI
- Glycosylation and Glycoproteins Research
- Domain Adaptation and Few-Shot Learning
- Cryptography and Data Security
- Text and Document Classification Technologies
- Retinal and Optic Conditions
- Digital Imaging for Blood Diseases
- Medical Image Segmentation Techniques
- Visual Attention and Saliency Detection
- Radiopharmaceutical Chemistry and Applications
- MRI in cancer diagnosis
- Human Mobility and Location-Based Analysis
- Advanced X-ray Imaging Techniques
- Bacteriophages and microbial interactions
Lanzhou Jiaotong University
2024
Xi'an Chest Hospital
2023
Jiangsu Province Hospital
2023
Shandong First Medical University
2023
Shandong Tumor Hospital
2023
Beijing Hospital of Traditional Chinese Medicine
2023
Capital Medical University
2023
Nanjing Medical University
2018-2023
Jinling Institute of Technology
2023
Tianjin Hospital
2023
Corneal regeneration has always been a challenge due to its sophisticated structure and undesirable keratocyte-fibroblast transformation. Herein, we propose 3D printing of biomimetic epithelium/stroma bilayer implant for corneal regeneration. Gelatin methacrylate (GelMA) long-chain poly(ethylene glycol) diacrylate (PEGDA) are blended form two-component ink, which can be printed different mechanically robust programmed PEGDA-GelMA objects by Digital Light Processing (DLP) technology, the...
Abstract This study aimed to investigate postinfarct left ventricular (LV) fiber structural alterations by ex vivo diffusion tensor imaging (DTI) in a porcine heart model. In cardiac MR was first performed measure function six adult pigs with septal infarction near apex induced the LAD ligation 13 weeks earlier. Hearts were then excised from infarct ( n = 6) and intact controls fixed formalin. High‐resolution DTI employed examine changes fractional anisotropy (FA), apparent coefficient...
The outbreak of coronavirus disease 2019 (COVID-19) that occurred in Wuhan, China, has become a global public health threat. It is necessary to identify indicators can be used as optimal predictors for clinical outcomes COVID-19 patients.The information from 126 patients diagnosed with were collected Wuhan Fourth Hospital. Specific characteristics, laboratory findings, treatments and analyzed hospitalized treatment 1 February 15 March 2020, subsequently died or discharged. A random forest...
We propose a joint segmentation and classification deep model for early glaucoma diagnosis using retina imaging with optical coherence tomography (OCT). Our motivation roots in the observation that ophthalmologists make clinical decision by analyzing retinal nerve fiber layer (RNFL) from OCT images. To simulate this process, we novel joins classification. consists of three parts. First, network simultaneously predicts both six layers five boundaries between them. Then, introduce post...
Purpose: To detect injury of whole brain white matter (WM) in normal tension glaucoma (NTG) patients by using diffusion tensor imaging (DTI) and to analyze the correlations between DTI parameters indices. Methods: Twenty mild, 17 moderate, 18 severe NTG as well 25 subjects were enrolled this study. Atlas-based analysis was performed measure fractional anisotropy (FA), mean diffusivity (MD), axial (AD), radial (RD). One-way analyses variance used for comparisons subgroups control (NC) group....
This retrospective consecutive case series aimed to evaluate spectral-domain optical coherence tomography (SD-OCT) for occult macular disease recognition preoperatively in patients scheduled routine cataract surgery. All surgery underwent SD-OCT. Scans were reviewed retinal, retinal pigment epithelium and vitreomacular interface abnormalities. For the subgroup analysis, following information was collected: age; sex; diabetes, hypertension, myopia, glaucoma, post intra-ocular surgery,...
The identification of panels tumor antigens that elicit an antibody response may have utility in cancer screening, diagnosis and establishing prognosis. However, autoantibodies normally exist sera healthy individuals are enormously diversified. To explore the reservoir autoantibody population, we performed a proteomics investigation profiles 36 Chinese from Beijing, which provide valuable reference information to disease-specific autoantibodies. results showed varied individually, but some...
Objective To explore a prediction model for lymphovascular invasion (LVI) on cT 1–2 N 0 M radiologic solid non-small cell lung cancer (NSCLC) based 2-deoxy-2[ 18 F]fluoro-D-glucose ([ F]F-FDG) positron emission tomography-computed tomography (PET-CT) radiomics analysis. Methods The present work retrospectively included 148 patients receiving surgical resection and verified pathologically with NSCLC. cases were randomized into training or validation sets in the ratio of 7:3. PET CT images...
To demonstrate an in vivo magnetic resonance imaging (MRI) technique that maps the cyclic change of regional myocardial blood volume (MBV) during cardiac cycle.The method is based on dominant T(2)* shortening effect iron oxide nanoparticle-induced susceptibility perturbation myocardium steady state. The was demonstrated with normal mouse hearts at 9.4 T. MBV left ventricular were computed from steady-state pre- and post-monocrystalline nanoparticle (MION) gradient echo (GE) cine images....
Chronic restraint stress (CRS) can affect hypothalamic-pituitary-adrenal (HPA) axis activity and increase glucocorticoid levels. Glucocorticoids are hormones that regulate multiple aspects of energy homeostasis. Stress also impairs glucose tolerance. The aim this study was to investigate the cause insulin-resistant hyperglycemia during CRS. We produced CRS models (a 7-day followed by a 3-day free moving procedure, total 4 cycles for 40 days) in mice, detected parameters related metabolism,...
Pulmonary nodules (PNs) shown as persistent or growing ground-glass opacities (GGOs) are usually lung adenocarcinomas their preinvasive lesions. Tumor mutation burden (TMB) and somatic mutations important determinants for the choice of strategy in patients with cancer during therapy. A total 93 post-operative 108 malignant PNs were enrolled analysis (75 cases training cohort 33 validation cohort). Radiomics features extracted from preoperative non-contrast computed tomography (CT) images...
Background: Exposure of high dose ionizing radiation is lethal. Signal pathways involved in biology reaction still remain illdefined. Lipopolysaccharides (LPS), the ligands Toll-like receptor 4(TLR4), could elicit strong immune responses. Glycogen synthase kinase-3β(GSK-3β) promotes production inflammatory molecules and cell migration. Inhibition GSK-3β provides protection against inflammation animal models. The aim study was to investigate role LPS shock radiation. Methods: WT or...
The inadequate understanding of the structure–activity relationship (SAR) glycosite-specific antibody–drug conjugates (ADCs) hinders its design and development. Herein, we revealed systemic SAR structure–toxicity (STR) gsADCs by constructing 50 gsADC structures bearing three glycan subtypes diverse linker-drug combinations. According to results, extra hydrophilic linkers are indispensable for intact glycan-based achieve better in vivo efficacy. Meanwhile, that conjugate complexes onto...
Hepatic foreign bodies are quite rare. A sewing needle as a hepatic body in an old woman is very rare and the managements have been varied.An was incidentally found to her liver on abdominal X-ray. The kept stable after two years of follow-up. Eleven cases were reviewed.Sewing In general, should be removed through laparotomy or laparoscopy, but uncomplicated need not removed.
Tumor heterogeneity may lead to false negative test results for tissue biopsy-based companion diagnostic tests. Real-time polymerase chain reaction (PCR) and digital PCR assays are used detect rare alleles in cell-free circulating DNA liquid biopsies; however, those tests lack strong sensitivity at low allele frequencies. We show here a novel real-time instrument that utilizes cycle-based amplification curves further improve the quantification accuracy of PCR.The was compared an endpoint...
Image segmentation is a long-standing problem in medical image analysis to facilitate the clinical diagnosis and intervention. Progress has been made owing deep learning via supervised training with elaborate human labelling, however, models trained by labeled source domain cannot perform well target domain, making existing approaches lack robustness generalization ability. Considering acquisition of labels quite expensive time-consuming, we propose novel feature disentanglement-based...
Abstract Big data presents critical requirements for security in collection and transmission of selected through a communication network. This paper new secure big based on nested sparse sampling coprime sampling. With sampling, besides the advantage higher spectrum efficiency, could also achieve power spectral density binary frequency shift keying (BFSK) signal. When spacing pairs are enough, BFSK signal performs like hopping. property has great using FH/BFSK, as it low error probability....