A5100693506- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Medical Imaging Techniques and Applications
- Retinal Imaging and Analysis
- Glioma Diagnosis and Treatment
- Retinal and Optic Conditions
- Alzheimer's disease research and treatments
- Ocular Surface and Contact Lens
- Radiomics and Machine Learning in Medical Imaging
- Ophthalmology and Visual Impairment Studies
- Corneal surgery and disorders
- Ocular Diseases and Behçet’s Syndrome
- Gut microbiota and health
- Radiopharmaceutical Chemistry and Applications
- Gallbladder and Bile Duct Disorders
- Retinal Development and Disorders
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Lanthanide and Transition Metal Complexes
- Gastric Cancer Management and Outcomes
- Berberine and alkaloids research
- Ocular Oncology and Treatments
- Liver Disease Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Corneal Surgery and Treatments
Fudan University
2014-2024
Nantong University
2021-2024
Huashan Hospital
2013-2024
Jiangnan University
2021-2024
Wuxi No.2 People's Hospital
2013-2024
Shenzhen Polytechnic
2023-2024
Second Affiliated Hospital of Harbin Medical University
2022-2024
Harbin Medical University
2022-2024
Yangzhou University
2024
People’s University
2024
Abstract The phenylalanine–tyrosine–dopa–dopamine pathway provides dopamine to the brain. In this process, tyrosine hydroxylase (TH) is rate-limiting enzyme that hydroxylates and generates levodopa ( l -dopa) with tetrahydrobiopterin (BH 4 ) as a coenzyme. Here, we show oral berberine (BBR) might supply H • through dihydroberberine (reduced BBR produced by bacterial nitroreductase) promote production of BH from dihydrobiopterin; increased enhances TH activity, which accelerates -dopa gut...
The progression of hyperuricemia disease is often accompanied by damage to renal function. However, there are few studies on nephropathy, especially its association with intestinal flora. This study combines metabolomics and gut microbiota diversity analysis explore metabolic changes using a rat model as well the in flora composition. results showed that amino acid metabolism was disturbed serine, glutamate glutamine being downregulated whilst glycine, hydroxyproline alanine upregulated....
Abstract The purpose of the current study was to investigate effect topical atropine on choroidal thickness using spectral-domain optical coherence tomography. A total 30 healthy eyes from children were analyzed in this study. single drop 1% gel administered twice daily for a week. Choroidal (CT) measured SD-OCT, and changes CT before after administration eye drops at subfovea 1.0-mm intervals (up 3.0 mm) fovea superior, inferior, nasal, temporal locations. Pre- post-cycloplegic axial length...
Purpose.: To investigate the longitudinal changes in choroidal thickness of eyes diabetic retinopathy patients during 12 weeks after panretinal photocoagulation (PRP). Methods.: This prospective, comparative study included 46 undergoing four-session PRP. At baseline and 1, 4, 8, completion PRP treatments, subfoveal (SFCT) was measured by using enhanced depth imaging optical coherence tomography. Also were central macular (CMT) best-corrected visual acuity (BCVA). Results.: The mean SFCT at...
Abstract The purpose of the present study was to investigate vascular flow density (VD) macular superficial (SCP), deep capillary plexus (DCP), and choriocapillaris size foveal avascular zone (FAZ) area in healthy children using optical coherence tomography angiography (OCTA). potential associations age, sex, intraocular pressure, body mass index, spherical equivalent, axial length with OCTA parameters were also investigated. A total 75 eyes from included for analysis, mean age 11.51 ± 1.91...
Berberine (BBR) is an isoquinoline alkaloid extracted from Coptis chinensis that improves diabetes, hyperlipidemia and inflammation. Due to the low oral bioavailability of BBR, its mechanism action closely related gut microbiota. This study focused on CYP51 enzyme intestinal bacteria elucidate a new BBR transformation by demethylation in microbiota through multiple analytical techniques. First, docking was performed; then, pharmacokinetics determined ICR mice vivo, metabolism liver, kidney,...
Background: Periodontitis is associated with periodontal tissue damage and teeth loss. Nonalcoholic fatty liver disease (NAFLD) has an intimate relationship periodontitis. Nevertheless, interacted mechanisms between them have not been clear. This study was intended for the exploration of shared gene signatures latent therapeutic targets in periodontitis NAFLD. Methods: Microarray datasets NAFLD were obtained from Gene Expression Omnibus (GEO) database. The weighted co-expression network...
COVID-19, caused by SARS-CoV-2 virus, has emerged as a global threat to human health. The main protease (Mpro) of is an excellent target for the development antiviral drugs against and various biosensors have been developed evaluate anti-coronavirus drugs. However, application these was limited due high background fluorescence, poor signal-to-noise ratios, constraints in enzyme activity thresholds accessing live viruses. In this study, we rationally designed highly conserved Mpro cleavage...
Purpose. To observe and analyze corneal asphericity its related factors in Chinese subjects. Methods. The of 1052 right eyes from a population was determined using the Wavelight-ALLEGRO Topographer. coefficient Q describes rate curvature variation cornea center to periphery specifies type conicoid that best represents shape. All cases were grouped by age years (A: ≤9; B: 10 19; C: 20 29; D: 30 39; E: 40 49; F: ≥50), 223 myopic magnitude spherical equivalent (SE) refractive error (low myopia,...
Purpose.: To evaluate macular thickness/volume in a Chinese population of primary school children using optical coherence tomography (OCT), and assess its association with age, sex, spherical equivalent refraction (SE), body mass index (BMI), intraocular pressure (IOP). Methods.: Healthy (n = 806) from six randomly selected schools Chongming County, Shanghai, China, were enrolled. Comprehensive standardized ophthalmic examinations included visual acuity, cycloplegic refraction, IOP, fast...
Background The canonical Wnt signaling pathway plays important roles in cellular proliferation and differentiation, axonal outgrowth, maintenance retinas. Here we test the hypothesis that elements of are involved regulation eye growth prevention myopia, mouse form-deprivation myopia model. Methodology/Principal Findings (1) One hundred twenty-five C57BL/6 mice were randomly distributed into control groups. Form-deprivation (FDM) was induced by suturing right eyelid, while group received no...
Associations were investigated between levels of chemokines and growth factors in the vitreous proliferative diabetic retinopathy (PDR). Enrolled 58 patients (58 eyes) requiring pars plana vitrectomy (PPV), with PDR (n=32, none traction retinal detachment) or not (non-PDR). In latter, 16 had macular hole (MH) 10 epiretinal membrane (ERM). With a multiplex bead immunoassay, 11 measured from undiluted sample each patient. non-PDR eyes, tested similar MH those ERM. However, all significantly...
Molecular imaging of tauopathies is complicated by the differing specificities and off-target binding properties available radioligands for positron-emission-tomography (PET). [18F]-APN-1607 ([18F]-PM-PBB3) a newly developed PET tracer with promising tau imaging. We aimed to characterize cerebral in Alzheimer's disease (AD) patients compared normal control (NC) subjects. Therefore, we obtained static late frame recordings [18F]-FDG clinical diagnosis AD group, along an age-matched NC group...
Left-right asymmetry, an important feature of brain development, has been implicated in neurodegenerative diseases, although it’s less discussed typical Alzheimer’s disease (AD). We sought to investigate whether asymmetric tau deposition plays a potential role AD heterogeneity. Two independent cohorts consisting patients with mild cognitive impairment due and dementia PET imaging were enrolled [the Disease Neuroimaging Initiative (ADNI) cohort 18F-Flortaucipir, the Shanghai Memory Study...
Liver hepatocellular carcinoma (LIHC) is one of the most common malignant tumors, which difficult to be diagnosed at an early stage due its poor prognosis. Despite fact that PANoptosis important in occurrence and development no bioinformatic explanation related LIHC can found. A bioinformatics analysis on data patients TCGA database was carried out basis previously identified PANoptosis-related genes (PRGs). were divided into two PRG clusters whose gene characteristics differentially...
Background and objective The widely applied 18F-FDG is known for its disadvantage in brain tumour PET imaging because of high background uptake. 11C-choline can achieve contrast was expected to have higher sensitivity specificity. We analysed the misdiagnoses tumours with aim improving accuracy diagnosis imaging. Patients methods selected 10 patients proven been misdiagnosed on basis histopathological correlation clinical follow-up among 94 (110 studies) who underwent PET/CT diagnosed or...