A5101409324- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal and Macular Surgery
- Liver physiology and pathology
- Hepatocellular Carcinoma Treatment and Prognosis
- Ocular Diseases and Behçet’s Syndrome
- Immune cells in cancer
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Lung Cancer Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Ophthalmology and Visual Impairment Studies
- Immune Response and Inflammation
- Acupuncture Treatment Research Studies
- Ocular Surface and Contact Lens
- NF-κB Signaling Pathways
- Corneal Surgery and Treatments
- Inflammation biomarkers and pathways
- Cell death mechanisms and regulation
- Epilepsy research and treatment
- MRI in cancer diagnosis
- Immunotherapy and Immune Responses
- Advanced Radiotherapy Techniques
- Neurological Disease Mechanisms and Treatments
- Cancer-related molecular mechanisms research
Nanjing Medical University
2014-2024
Army Medical University
2020-2024
Hara Eye Hospital
2024
Chongqing Medical University
2020-2024
Dalian Medical University
2020-2024
Second Affiliated Hospital of Chongqing Medical University
2020-2024
Nanjing Traditional Chinese Medicine Hospital
2024
Shaoyang University
2024
Fudan University
2013-2023
Zhongshan Hospital
2014-2023
Lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4) signaling pathway is demonstrated to be involved in the hepatic fibrosis. MicroRNA (miR)-146a-5p a key regulator of innate immune response. The functional significance miR-146a-5p during LPS/TLR4 mediated fibrosis process remains unclear. In this study, we found that TLR4 and α-smooth muscle actin (α-SMA) were up-regulated was down-regulated human stellate cell (HSC) line LX2 after LPS stimulation. Overexpression inhibited induced...
Background To demonstrate the efficacy and safety of intravitreal injections conbercept versus laser photocoagulation in treatment diabetic macular oedema (DME). Methods A 12-month multicentre, randomised, double-masked, double-sham, parallel controlled, phase III trial (Sailing Study), followed by a open-label extension study. Patients with centre-involved DME were randomly assigned to receive either pro re nata (PRN) sham (laser/sham) or PRN 0.5 mg (sham/conbercept). who entered study...
Objective This study aimed to investigate the clinical effects of Orff music therapy on children with Autism Spectrum Disorder (ASD) from perspectives parents, evaluators, and therapists. Methods 93 ASD aged 3–6 years participated in study. They were divided into an observation group ( n = 48) receiving comprehensive rehabilitation intervention including therapy, a control 45) only intervention. The Behavior Checklist (ABC), Childhood Rating Scale (CARS), Psycho-educational Profile-3rd...
Purpose: This study aimed to compare the donor–recipient interface changes between non‐Descemet stripping endothelial keratoplasty (nDSEK) and Descemet (DSEK) assess their correlation with postoperative best spectacle‐corrected visual acuity (BCVA). Methods: retrospective collected clinical data on patients corneal decompensation who underwent either nDSEK or DSEK August 2019 April 2023. The particle density, haze, outcome, graft dislocation were compared groups. Results: A total of 66 eyes...
Associations were investigated between levels of chemokines and growth factors in the vitreous proliferative diabetic retinopathy (PDR). Enrolled 58 patients (58 eyes) requiring pars plana vitrectomy (PPV), with PDR (n=32, none traction retinal detachment) or not (non-PDR). In latter, 16 had macular hole (MH) 10 epiretinal membrane (ERM). With a multiplex bead immunoassay, 11 measured from undiluted sample each patient. non-PDR eyes, tested similar MH those ERM. However, all significantly...
This study evaluated whether fish oil exerted a hepatoprotective effect in LPS-induced liver injury model via regulation of TLR4 and nucleotide-binding oligomerization domain protein (NOD) signaling pathways. Twenty-four piglets were used 2 × factorial design, the main factors included diet (5% corn or 5% oil) immunological challenge (LPS saline). Fish resulted enrichment eicosapentaenoic acid, docosahexaenoic acid total (n-3) polyunsaturated fatty acids liver. Less severe was observed pigs...
Adenylyl cyclase (AC)-cyclic adenosine monophosphate (cAMP)-cAMP-dependent protein kinase A (PKA) cascade is considered to be associated with the pathogenesis and treatment of depression. The present study was conducted explore role cAMP in antidepressant action electroacupuncture (EA) for chronic mild stress (CMS)-induced depression model rats. results showed that EA improved significantly behavior symptoms dysfunction AC-cAMP-PKA signal transduction pathway induced by CMS, which as...
It is well established that some irradiated liver non-parenchymal cells secrete pro-inflammatory cytokines to facilitate the development of radiation-induced disease. However, little known on whether hepatoma cells-mediated non-irradiated hepatocyte injury occurs in HCC patients. Here, we elucidated roles driving and its underlying mechanism.SMMC7721 were cultured divided into (4-Gy X-ray, R) (NR) groups. At 24th hour after irradiation, conditioned medium (CM) from these cultures was mixed...
The optimal treatment for adrenal metastases from hepatocellular carcinoma (HCC) has not been established. This study analyzed the effects of radiation therapy (RT) such and identified clinical features predictors survival in these patients. We retrospectively investigated 55 patients with metastasis HCC who had treated RT. Radiation doses to lesions ranged 26 60 Gy, while intrahepatic were by surgical resection, transarterial chemoembolization (TACE), liver transplantation, and/or RT was...
Abstract Background Human leukocyte antigen-E (HLA-E) has been extensively investigated in various human cancers including glioma. However, the clinical significance of HLA-E expression glioma patients not elucidated. The current study aimed to investigate association with clinicopathological features and survival diffuse Methods A total 261 were enrolled, subsequently, mRNA microarray analysis was conducted identify relationship patient survival. Results significantly overexpressed...
Objectives The aim of this study was to develop a radiomics model for differential diagnosis focal-type autoimmune pancreatitis (AIP) from pancreatic ductal adenocarcinoma. Methods A total 96 patients, 45 with AIP and 51 adenocarcinoma, were retrospectively evaluated. All patients underwent pretreatment abdominal computed tomography imaging acquired at noncontrast, arterial, venous phases. Furthermore, 1160 features extracted each phasic image build models. performance evaluated by...
Objectives This study aimed to develop a computed tomography (CT)–based deep learning model for assessing the severity of patients with connective tissue disease (CTD)–associated interstitial lung (ILD). Methods The retrospective included 298 CTD-ILD between January 2018 and May 2022. A learning–based RDNet was established (1610 fully annotated CT images training 402 validation). used automatically classify quantify 3 radiologic features (ground glass opacities [GGOs], reticulation,...
Perifoveal exudative vascular anomalous complex (PEVAC) is a recently described macular entity, which can be confused with other well-known lesions such as retinal angiomatous proliferation. more common than previously believed and usually unresponsive to anti-vascular endothelial growth factor treatment. Clinicians should aware of this disorder.The purpose study was report case PEVAC using multimodal imaging in Chinese patient diabetes mellitus but without diabetic retinopathy, followed by...