A5008001419- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Intraocular Surgery and Lenses
- Retinal and Macular Surgery
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Ocular Diseases and Behçet’s Syndrome
- Ophthalmology and Visual Impairment Studies
- Ocular Surface and Contact Lens
- Retinopathy of Prematurity Studies
- Ophthalmology and Eye Disorders
- Ocular Oncology and Treatments
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Connexins and lens biology
- interferon and immune responses
- Retinoids in leukemia and cellular processes
- Angiogenesis and VEGF in Cancer
- Traumatic Ocular and Foreign Body Injuries
- Cell Adhesion Molecules Research
- Systemic Lupus Erythematosus Research
- Photoreceptor and optogenetics research
- Neuroinflammation and Neurodegeneration Mechanisms
- Ocular Infections and Treatments
Wuhan University
2015-2024
Renmin Hospital of Wuhan University
2015-2024
He Eye Hospital
2023
Shandong Eye Hospital
2022
Ophthalmology Associates (United States)
2008
Ten Chen Hospital
2007
Diabetic retinopathy (DR) is a highly tissue-specific neurovascular complication of type 1 and 2 diabetes mellitus among the leading causes blindness worldwide. Pathophysiological changes in DR encompass neurodegeneration, inflammation, oxidative stress. Current treatments for DR, including anti-vascular endothelial growth factor, steroids, laser photocoagulation, vitrectomy have limitations adverse reactions, necessitating exploration novel treatment strategies. This review aims to...
Purpose: To develop a new intelligent system based on deep learning for automatically optical coherence tomography (OCT) images categorization. Methods: A total of 60,407 OCT were labeled by 17 licensed retinal experts and 25,134 included. One hundred one-layer convolutional neural networks (ResNet) trained the We applied 10-fold cross-validation method to train optimize our algorithms. The area under receiver operating characteristic curve (AUC), accuracy kappa value calculated evaluate...
Abstract Background The baseline data pertaining to the national epidemiological survey of infectious keratitis remain scarce in China, and currently there is no corneal blindness control strategy developed by nation. Methods Geographically defined cluster sampling was used randomly select a cross-section residents from representative urban rural populations Hubei Province. Participants were selected village registers, followed door-to-door household visits. assessment items included...
To compare optical coherence tomography angiography (OCTA) screening parameters of the macula and optic nerve head (ONH) between healthy volunteers chronic hypertensive patients without retinopathy.This was an observational, cross-sectional study. Fifty-seven retinopathy (22 men 35 women) 40 (17 23 women), ranging in age from 60 to 70 years, were included this Patients divided into three groups one eye selected randomly each participant. Group A comprised who had a history hypertension for...
To investigate the independent risk factors of dry eye syndrome (DES) in Chinese.A hospital-based age- and sex-matched population was enrolled with a case-control ratio 1:2, 789 DES case patients 1119 healthy family members. Both groups underwent standard ophthalmologic examinations, including slit-lamp evaluation anterior segment, measurement tear film breakup time, Schirmer test, corneal fluorescein staining. Data on demographic characteristics lifestyle habits were collected using...
Diabetic retinopathy, a severe complication of diabetes, is the leading cause blindness in developed world. This study investigated effects quercetin on levels monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9) and vascular endothelial growth factor (VEGF) serum rats with diabetic explored functional mechanisms treatment retinopathy. Twenty induced diabetes were divided into model group group, 10 each group. Ten healthy also included to serve as control Rats...
Abstract Background This study aimed to identify the gene variants and molecular etiologies in 76 unrelated Chinese families with retinitis pigmentosa (RP). Methods In total, syndromic or nonsyndromic RP, diagnosed on basis of clinical manifestations, were recruited for this study. Genomic DNA samples from probands analyzed by targeted panels whole exome sequencing. Bioinformatics analysis, Sanger sequencing, available family member segregation used validate sequencing data confirm...
Chemotherapy is an important part of retinoblastoma (RB) treatment. However, the development drug resistance increases likelihood treatment failure. Therefore, increasing sensitivity chemotherapeutic drugs very important. Recent research has explored relationship between expression level gasdermin E (GSDME) and in RB. Our study found that GSDME was significantly reduced human RB tissues cell lines. Downregulation cells to drugs. Decitabine transfection with GSDME-overexpressing lentivirus...
Purpose To determine possible correlations between different levels of blood pressure (BP) control and retinal microvascular changes in the macula optic nerve head, using coherence tomography angiography (OCTA) hypertensive patients without retinopathy.Methods This was an observational, cross-sectional study. Seventy-three 40 healthy volunteers were included this The divided into four groups from each participant one eye selected randomly: Group A comprised 32 with intensive BP control; B 26...
Submacular hemorrhage (SMH) is the accumulation of blood in macular area that can severely damage structure and visual function. Recently, intraocular administration tissue plasminogen activator (TPA) with anti-vascular endothelial growth factor (anti-VEGF) drugs was reported to have a positive effect on SMH. This meta-analysis aimed explore efficacy safety drug combination. We systematically searched Web Science, MEDLINE, EMBASE, Cochrane Library databases screened relevant full-length...
The purpose was to investigate the protective effects of Vitamin C (Vit C) and regulatory mechanism between Vit sirtuin 1 (SIRT1) in PREs during oxidative stress as SIRT1 exerted famous antioxidants. We found that moderate (100 µ M) prevented ARPE-19 cells from damages induced by H 2 O , including increasing viability, reducing apoptosis, attenuating intracellular ROS levels. But lower higher concentration had no effects. Further results indicated caused dysregulation some responses factors...