A5002308128- Wastewater Treatment and Nitrogen Removal
- TGF-β signaling in diseases
- Hippo pathway signaling and YAP/TAZ
- Bone Tissue Engineering Materials
- Glaucoma and retinal disorders
- Cancer-related Molecular Pathways
- Bone Metabolism and Diseases
- Viral gastroenteritis research and epidemiology
- Vibrio bacteria research studies
- Connexins and lens biology
- Cancer Genomics and Diagnostics
- Cell Adhesion Molecules Research
- Cell death mechanisms and regulation
- Microbial Fuel Cells and Bioremediation
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Escherichia coli research studies
- Single-cell and spatial transcriptomics
- Nuclear Receptors and Signaling
- Neuroinflammation and Neurodegeneration Mechanisms
- Bone health and treatments
- Animal Virus Infections Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Diabetes Management and Research
- Circular RNAs in diseases
Shanghai University of Traditional Chinese Medicine
2025
Wenzhou Medical University
2021-2025
Beijing University of Technology
2024
Peking University
2024
Center for Life Sciences
2024
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Sun Yat-sen University
2020-2024
First Affiliated Hospital of Wenzhou Medical University
2021-2024
Beijing University of Chinese Medicine
2020-2024
Inner Mongolia Medical University
2024
Hippo signaling is a tumor-suppressor pathway involved in organ size control and tumorigenesis through the inhibition of YAP TAZ. Here, we show that energy stress induces cytoplasmic retention S127 phosphorylation inhibits transcriptional activity YAP-dependent transformation. These effects require central metabolic sensor AMP-activated protein kinase (AMPK) upstream components Lats1/Lats2 angiomotin-like 1 (AMOTL1). Furthermore, AMPK directly phosphorylates S793 AMOTL1. activation...
To compare optical coherence tomography angiography (OCTA) screening parameters of the macula and optic nerve head (ONH) between healthy volunteers chronic hypertensive patients without retinopathy.This was an observational, cross-sectional study. Fifty-seven retinopathy (22 men 35 women) 40 (17 23 women), ranging in age from 60 to 70 years, were included this Patients divided into three groups one eye selected randomly each participant. Group A comprised who had a history hypertension for...
Abstract Background Bone fracture repair has gained a lot of attention due to the high incidence delayed union or even nonunion especially in osteoporotic patients, resulting dreadful impact on quality life. However, current therapies involve costly expense and hence become unaffordable strategies for recovery. Herein, developing new better bone is essential urgent. Catalpol treatment been reported attenuate loss promote formation. mechanisms underlying its effects remain unraveled. Methods...
Background: Hot-melt Pressure-sensitive Adhesives (HMPSA) are eco-friendly pressuresensitive adhesives, with the potential of being used as substrates for transdermal patches. However, due to low hydrophilicity HMPSA, application is limited in field Traditional Chinese Medicine (TCM) plasters. Methods: Three modified HMPSA were prepared acrylic resin EPO, RL100, and Polyvinylpyrrolidone (PVP) modifying materials. The physical compatibility between materials was investigated through vitro...
Sarcopenia is a disease characterized by losing muscle mass, strength, and function with age. Studies have shown that sarcopenia generally higher in women than men. Therefore, this study used the 2015 China Health Retirement Longitudinal Study (CHARLS) data to explore further risk factors associated middle-aged older Chinese women. In study, from CHARLS database were analyzed, comprising 7,805 eligible participants. Participants categorized into either group (n = 2,160) or non-sarcopenia...
Ulcerative colitis (UC), a chronic disease characterized by continuous damage to the intestinal mucosa and inflammation in colon, comprises series of gastrointestinal reactions is difficult cure. Here, we have designed nanotherapeutic strategy combining pharmacotherapy with physical protection, which achieved constructing green nanocarrier named cyclodextrin-based nanosponges (CDNSs) encapsulating insoluble drug parthenolide (PTL). CDNSs were transformed into hydrogel driven water, releasing...
To design a shared scenic mobility scooter that is more in line with the smart city lead. This paper proposes KJ-AHP integration method to assist of intelligent scooters.First, list user functional requirements mined through KJ method.Secondly, AHP used filter and construct hierarchical model calculate weight values each factor output prioritised results.Finally, appropriate strategies are proposed.The has certain operability superiority, providing scientific reference basis for later...
Transforming growth factor-beta (TGF-beta) functions as a tumor suppressor of the prostate through mechanisms that remain unresolved. Although TGF-beta receptors directly activate both Smads 2 and 3, to date, Smad3 has been shown be essential mediator most Smad-dependent responses, including control gene expression, cell growth, apoptosis, suppression. Using robust lentiviral short hairpin RNA system silence and/or 3 in NRP-152 nontumorigenic rat basal epithelial line, we provide first...
Background: LncRNAs play an essential role in a variety of diseases. Zinc finger antisense 1 (ZFAS1), newly identified lncRNA, is transcript to the 5ʹ end gene Znfx1. The purpose this study was aim compare levels ZFAS1 between ischemic stroke (IS) and healthy control subjects explore its potential as noninvasive biomarker diagnosis IS. Methods: A total 176 patients 111 controls were included study. RT-qPCR performed detect expression ZFAS1. Results: results showed that level IS significantly...
Alzheimer's disease (AD), as one of most common dementia, mainly affects older people from the worldwide. In this study, we intended to explore possible mechanism improving cognitive function and protecting neuron effect by electroacupuncture.
Survivin is a unique member of the inhibitor apoptosis (IAP) proteins that overexpressed in numerous cancers through poorly defined mechanisms. One such mechanism may be constitutive activation insulin-like growth factor-I (IGF-I) signaling pathway, implicated development and progression prostate cancer. Using pre-neoplastic NRP-152 rat cell line as model, we showed IGF-I induces expression, silencing by lentiviral-mediated small hairpin RNA (shRNA) represses IGF-I-stimulated growth,...
Accumulating evidence suggests that improvements in osteogenesis and angiogenesis play an important role repairing osteoporotic bone defects. Cinnamomum cassia (C. cassia), a traditional Chinese medicinal herb, is reported to show anabolic effects on osteoblasts. However, whether C. could actually repair defects conditions remains unknown. The purpose of this study was evaluate the effect combined treatment with Cinnamaldehyde (main oil isolated from cassia) β-tricalcium phosphate (β-TCP)...
Osteoporosis is a common systemic skeletal disorder that leads to increased bone fragility and risk of fracture. Although βII-Spectrin (SPTBN1) has been reported be involved in the development various human cancers, function underlying molecular mechanisms SPTBN1 primary osteoporosis remain unclear. In this study, we first established mouse model senile postmenopausal osteoporosis. The results showed expression was significantly downregulated mice compared with control group. Furthermore,...
<b><i>Background:</i></b> Recent study found that microRNA (miRNA) are involved in diabetic kidney disease (DKD). The objective of this is to determine the role miR302a-3p process renal epithelial-mesenchymal transition (EMT) DKD. <b><i>Methods:</i></b> miRNA expression profiling cell line stimulated by high glucose was performed a microarray analysis. Then real-time polymerase chain reaction (PCR) were used one miRNAs significantly upregulated...
Abstract Background Renal fibrosis is the pathological foundation of various chronic kidney diseases progressing to end stage renal failure. However, there are currently no nephroprotective drugs targeted fibrotic process in clinical practice. Proteolytic targeting chimeras (PROTACs), which reversibly degrade target proteins through ubiquitin–proteasome pathway, a novel therapeutic modality. Smad3 key pathogenic factor fibrogenesis while HIF-2α exhibits prominent protective effects, natural...
Studies have found overexpressed integrin-linked kinase (ILK) and disturbed matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 (MMP-9/TIMP-1) ratio in diabetic nephropathy epithelial-mesenchymal transition (EMT). However, the underlying mechanisms EMT inhibiting effect rhein need further understanding. The aim this study was to investigate possible regulating effects ILK towards MMP-9/TIMP-1 rhein. characteristic epithelial marker mesenchymal were examined by...