A5009894144- Advanced Drug Delivery Systems
- Advancements in Transdermal Drug Delivery
- Nanoparticle-Based Drug Delivery
- Metal-Organic Frameworks: Synthesis and Applications
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Mesoporous Materials and Catalysis
- Molecular Sensors and Ion Detection
- Extracellular vesicles in disease
- Lung Cancer Research Studies
- Magnetism in coordination complexes
- Supramolecular Self-Assembly in Materials
- Microencapsulation and Drying Processes
- Wound Healing and Treatments
- Immune cells in cancer
- Meat and Animal Product Quality
- Oral Health Pathology and Treatment
- Hair Growth and Disorders
- Probiotics and Fermented Foods
- Proteins in Food Systems
- Analytical Chemistry and Chromatography
- Crystallography and molecular interactions
- Polysaccharides and Plant Cell Walls
- Oral health in cancer treatment
Shanghai University of Traditional Chinese Medicine
2019-2025
National University of Singapore
2025
Shanghai Institute of Materia Medica
2017-2019
Chinese Academy of Sciences
2017-2019
Jiangxi University of Traditional Chinese Medicine
2018
Intranasal administration through the olfactory epithelium (OE) presents a direct pathway for brain-targeted therapeutic delivery, although its feasibility is hampered by anatomical and absorptive limitations of OE. In this study, we identified Lactobacillus plantarum WCFS1 (Lp), commensal strain with natural affinity OE engineered it to function as vector cerebral drug delivery. Upon intranasal administration, Lp released specific payload molecules within OE, subsequent transport...
Tremendous efforts have been devoted to the enhancement of drug solubility using nanotechnologies, but few them are capable produce particles with sizes less than a nanometers. This challenge has addressed here by biocompatible versatile γ-cyclodextrin (γ-CD) metal-organic framework (CD-MOF) large molecular cages in which azilsartan (AZL) was successfully confined producing clusters nanometer range. strategy allowed improve bioavailability AZL Sprague–Dawley rats 9.7-fold after loading into...
Due to the lack of a delivery system that actively targets hypertrophic scar fibroblasts (HSFs), it is difficult concentrate effects drugs on scars (HSs). We recently discovered HSF membrane has homologous targeting effect and developed an active targeted drug for local treatment HSs. A diphenyl carbonate cross-linked cyclodextrin metal organic framework (CDF) containing more than 26% (w/w) quercetin (QUE) was coated with (QUE@HSF/CDF) then dispersed in Bletilla striata polysaccharide...
Abstract Background Breast cancer lung metastasis occurs in more than 60% of all patients with breast cancer, and most those afflicted by it eventually die recurrence. The tumor microenvironment plays vital roles metastasis. Modulating the via multiple pathways could efficiently prevent or inhibit Silibinin cryptotanshinone are natural plant products that demonstrate anti-metastasis effects modulate different pathways. However, they have poor aqueous solubility, membrane permeability, oral...
A red blood cell membrane (RBCm)-derived drug delivery system allows prolonged circulation of an antitumor treatment and overcomes the issue accelerated clearance induced by PEGylation. However, RBCm-derived systems are limited low drug-loading capacities lack tumor-targeting ability. Thus, new designs RBCm-based needed.
Ulcerative colitis (UC), a chronic disease characterized by continuous damage to the intestinal mucosa and inflammation in colon, comprises series of gastrointestinal reactions is difficult cure. Here, we have designed nanotherapeutic strategy combining pharmacotherapy with physical protection, which achieved constructing green nanocarrier named cyclodextrin-based nanosponges (CDNSs) encapsulating insoluble drug parthenolide (PTL). CDNSs were transformed into hydrogel driven water, releasing...
Some cancer cell membrane (CCM)-derived nanovesicles show strong homing effects and are used for targeted therapy. By co-constructing the B16F10 with a PEGylated phospholipid membrane, new nanocarrier composite nanocrown structure was developed, which can evade immune recognition actively target homologous melanoma. The nanocrowns have an encapsulation efficiency of more than 90% paclitaxel showed no significant difference (p > 0.05) from vesicles. Compared hyaluronic acid-modified vesicles,...
The microsphere was a primary particulate system for taste-masking with unique structural features defined by production process. In this article, ibuprofen lipid microspheres of octadecanol and glycerin monostearate were prepared to mask the undesirable taste via three kinds spray congealing processes, namely, air-cooling, water-cooling citric acid solution-cooling. stereoscopic internal structures quantitatively analyzed synchrotron radiation X-ray micro-computed tomography (SR-µCT)...
Food is a known primary role to the exposure of drugs orally administered. Since each animal may have unique food taking pattern and it difficult manipulate animals, there lacks rationalized protocol for effects in pre-clinic study. The objective this study was identify beagle patterns demonstrate their on bioavailability valsartan. Herein, four types were identified via inter-day intra-day analysis, named as Persisting, Pulsing, Postponing, Pushing ("4P Modes"), respectively, which also...