A5043635145- Gut microbiota and health
- Advanced biosensing and bioanalysis techniques
- Biopolymer Synthesis and Applications
- Probiotics and Fermented Foods
- Cancer Research and Treatments
- Clostridium difficile and Clostridium perfringens research
- Supramolecular Self-Assembly in Materials
- Food Quality and Safety Studies
- Pharmacological Effects of Natural Compounds
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Olfactory and Sensory Function Studies
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- DNA and Nucleic Acid Chemistry
- 3D Printing in Biomedical Research
- Luminescence and Fluorescent Materials
- Biochemical Analysis and Sensing Techniques
- Click Chemistry and Applications
- Antifungal resistance and susceptibility
- Polyamine Metabolism and Applications
- Cancer therapeutics and mechanisms
National University of Singapore
2018-2025
Nankai University
2015-2017
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2015-2017
Nuclear delivery and accumulation are very important for many anticancer drugs that interact with DNA or its associated enzymes in the nucleus. However, it is difficult neutrally negatively charged such as 10-hydroxycamptothecine (HCPT). Here we report a simple strategy to construct supramolecular nanomedicines nuclear of dual synergistic drugs. Our utilizes coassembly HCPT-peptide amphiphile positively cisplatin. The resulting nanomaterials behave "Trojan Horse" transported soldiers...
Intranasal administration through the olfactory epithelium (OE) presents a direct pathway for brain-targeted therapeutic delivery, although its feasibility is hampered by anatomical and absorptive limitations of OE. In this study, we identified Lactobacillus plantarum WCFS1 (Lp), commensal strain with natural affinity OE engineered it to function as vector cerebral drug delivery. Upon intranasal administration, Lp released specific payload molecules within OE, subsequent transport...
Abstract Prodrugs have been explored as an alternative to conventional chemotherapy; however, their target specificity remains limited. The tumor microenvironment harbors a range of microorganisms that potentially serve tumor-targeting vectors for delivering prodrugs. In this study, we harness bacteria-cancer interactions native the microbiome achieve high prodrug delivery. We identify oral commensal strain Lactobacillus plantarum with intrinsic cancer-binding mechanism and engineer enable...
Candida albicans is an opportunistic pathogen, with its infection as one of the causes morbidity or mortality. Notably, probiotic yeast Saccharomyces cerevisiae var. boulardii has shown potential to fight against infections. In this study, we aimed engineer a commercial strain produce medium-chain fatty acids (MCFAs) antagonistic effects C. albicans. First, identified and characterized created auxotrophic Δura3. Next, constructed expressed heterologous MCFA biosynthetic pathway under control...
We report in this study on optimized ratiometric fluorescent probes by peptide self-assembly. The resulting self-assembled nanoprobes show extraordinary stability aqueous solutions and extremely low background fluorescence buffer solutions. Our with much bigger ratios also an enhanced cellular uptake, lower noise, brighter signal the cell experiment. provides a versatile very useful strategy to design produce better performance.
Poly-γ-glutamic acid (γ-PGA) is a valuable polymer with glutamate as its sole precursor. Enhancement of the intracellular synthesis very important strategy for improvement γ-PGA production, especially those glutamate-independent producing strains. Corynebacterium glutamicum has long been used industrial production and it exhibits some unique features synthesis; therefore introduction these metabolic characters into strain might lead to increased availability, thus ultimate production.In this...