A5044298582- Metal complexes synthesis and properties
- Magnetism in coordination complexes
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Lanthanide and Transition Metal Complexes
- Metal-Organic Frameworks: Synthesis and Applications
- DNA and Nucleic Acid Chemistry
- Molecular Sensors and Ion Detection
- Nanoplatforms for cancer theranostics
- Metal-Catalyzed Oxygenation Mechanisms
- Advanced biosensing and bioanalysis techniques
- CRISPR and Genetic Engineering
- Advancements in Transdermal Drug Delivery
- Toxin Mechanisms and Immunotoxins
- Synthesis and Biological Evaluation
- Photodynamic Therapy Research Studies
- Luminescence Properties of Advanced Materials
- Advanced Nanomaterials in Catalysis
- Ferrocene Chemistry and Applications
- Essential Oils and Antimicrobial Activity
- Synthesis and Characterization of Heterocyclic Compounds
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Protein Interaction Studies and Fluorescence Analysis
- Seedling growth and survival studies
Nanjing University of Chinese Medicine
2022-2025
Chengdu University of Traditional Chinese Medicine
2025
Guizhou Minzu University
2024
Tianjin Normal University
2008-2023
Shanghai University of Traditional Chinese Medicine
2019-2022
Jiangsu Province Hospital
2022
Taiyuan Normal University
2021
Huashan Hospital
2020
Fudan University
2020
Sichuan University of Science and Engineering
2017
Two novel binuclear complexes [Cu2(L)]·(ClO4)2 (1) and [Zn2(L)]·(ClO4)2 (2) were synthesized crystallographically characterized {L = 14,54-dimethyl-12,52-dihydroxy-1(1,3),5(1,3)-dibenzene-3(1,4),7(1,4)-di-1,4,7-triazacyclononane}. The cation [Cu2(L)]2+ structure of 1 is similar to that [Zn2(L)]2+ 2. central ion bridged by the di-phenoxo L lies in a close perfect square pyramidal geometry. 2 crystallize triclinic space group P. two effectively promote cleavage plasmid DNA presence activating...
EGFR tyrosine kinase inhibitors (EGFR-TKIs) have garnered substantial clinical success in treating nonsmall cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations. However, the inevitable emergence of drug resistance, frequently attributed to activation, mutation, or deletion multiple signaling pathways, poses a significant challenge. Notably, loss PTEN protein expression has emerged as pivotal mechanism fostering resistance mutant cancers. Consequently,...
Two water-soluble zinc complexes, [Zn(L)Cl2] (1) and [Zn2(L)2(μ-C2O4)(H2O)2]·(ClO4)2·CH3OH (2) (L = N,N-bis(2-pyridylmethyl)methylamine), were prepared to serve as nuclease mimics. The complexes characterized by X-ray, IR UV-vis spectroscopy well ESI-MS. electrospray mass spectrum of 2 in solution indicates that dinuclear ion [Zn2(L)2(μ-C2O4)(ClO4)]+ (3) is the active species. UV-Vis absorption fluorescence studies show partially intercalate CT-DNA. In absence reducing agent, supercoiled...
A new 1,4,7-triazacyclononane derivative, 4-benzyloxy-benzyl-1,4,7-triazacyclononane (btacn), and three associated cyclen complexes, Cu(btacn)Cl2, Zn(btacn)Cl2 [Cu(btacn)2]·(ClO4)2, were prepared to serve as DNA synthesis interferents. The compounds characterized using IR, 1H 13C NMR, ESI-MS, elemental analysis X-ray single crystal diffraction methods, their damage mechanisms cytotoxicities towards cancer normal cells studied. Among them, Cu(btacn)Cl2 [Cu(btacn)2]·(ClO4)2 exhibit potent...
In the current study, diethylene glycol monoethyl ether-mediated microemulsions were combined with microneedles for enhanced transdermal aconitine delivery. The oil-in-water microemulsion increasedaconitine solubility and drug delivery assistance metal permeation of aconitine-loaded microemulsion. Carried by microemulsion, in vitro permeability was significantly enhanced, further improved using microneedles. vivo microdialysis revealed that subcutaneous local concentration reached a high...
A zinc(ii)-based coordination polymer (CP), namely [Zn(modbc)2] n (Zn-CP) (modbc = 2-methyl-6-oxygen-1,6-dihydro-3,4'-bipyridine-5-carbonitrile), has been synthesized and characterized. Single-crystal structural determination reveals that Zn-CP is a two-dimensional framework structure with tetranuclear homometallic Zn4(modbc)4 units cross-linked by modbc. The excellent luminescence as well good stability of do not enable it to have selective sensing capability for different ions. After...
Some cancer cell membrane (CCM)-derived nanovesicles show strong homing effects and are used for targeted therapy. By co-constructing the B16F10 with a PEGylated phospholipid membrane, new nanocarrier composite nanocrown structure was developed, which can evade immune recognition actively target homologous melanoma. The nanocrowns have an encapsulation efficiency of more than 90% paclitaxel showed no significant difference (p > 0.05) from vesicles. Compared hyaluronic acid-modified vesicles,...
To improve the treatment efficiency of ferroptosis and accurately monitor therapy process, we developed small-sized upconversion nanoparticles (UCNPs) by a simple one-step solvothermal method. On this basis, facile strategy is reported to construct mesoporous SiO2-coated UCNPs as nanocarrier load dual drugs MnO2 methylene blue (MB) photosensitizer for hypoxic tumor theranostic. Due components high charge elements, synthetic NaErF4:Yb,Gd,Eu@mSiO2/MnO2/MB@FA (UPSMF/MB, FA = folic acid)...
Abstract A new trinuclear manganese(II) complex {[MnCl(bpma)] 2 [Mn(μ‐Cl) 4 (H O) ]} · CH 3 CN ( 1 ) [bpma = N , ‐bis(2‐pyridylmethyl)methylamine] has been synthesized and structurally characterized by X‐ray crystallography. The variable temperature‐dependent susceptibility measurement (2–300 K) of reveals a weak antiferromagnetic interaction between the manganese ions through dichlorido bridging ligands, with J –0.46 cm –1 g 1.99. electrospray ionization mass spectrum in solution indicates...
Triple-negative breast cancer (TNBC) is a heterogeneous disease with multiple biological subtypes, offering poor clinical outcomes. No targeted therapy was approved for TNBC due to lack of tumor-specific targets. Here, we identify SerpinB9 as vulnerability target immunomodulatory tumors, suggesting that gene editing via the CRISPR/Cas9 system may be viable approach TNBC-targeted therapy. To increase bioavailability and improve delivery efficiency editing, designed glutathione-responsive...
Hypoxia is one of the most typical features among various types solid tumors, which creates an immunosuppressive tumor microenvironment (TME) and limits efficacy cancer treatment. Alleviating hypoxia becomes a key strategy to reshape hypoxic TME improves immunotherapy. However, it remains challenging perform precision therapy with controllable switches through hypoxia-activated gene editing prodrugs alleviate hypoxia. In this study, silica-coated second near-infrared window (NIR-II) emitting...
Two new µ-carboxylato-bridged binuclear copper(II) complexes [Cu2(bpea)2 (µ-C2O4)](ClO4)2 · H2O (1) and [Cu2(bpma)2 (µ-ta)](ClO4)2 (2) (bpea = N,N-bis(2-pyridylmethyl)ethylamine; bpma N,N-bis(2-pyridylmethyl)methylamine; ta terephthalate dianion) have been synthesized structurally determined by X-ray diffraction. Complex 1 is crystallized in a monoclinic space group C 2 /c with unit cell parameters 21.539(17) Å, b 12.608(10) c 13.117(11) β 96.788(13)°. In 1, each Cu(II) five-coordinate,...
In this work, a chloro-bridged trinuclear copper complex {[Cu(bpea)Cl]2CuCl4} (1) (bpea = N,N-bis(2-pyridylmethyl)ethylamine) has been synthesized and structurally characterized. 1, two mononuclear [Cu(bpea)Cl]+ are linked by one , generating sandwich-like unit. A crystallographic C2 axis passes through the Cu of connecting . Susceptibility data 1 indicate weak intratrimer ferromagnetic coupling with J 5.16 cm−1. Elemental analysis, infrared, UV spectra, electrochemistry were also determined.
Ion-responsive probes have gathered significant attention because of health and environmental factors, but there are few reports on the "turn-on" mechanism Fe3+ sensitive detection Br– by fluorescence measurement. Herein, a green luminescence material, N-5-acetyl-2-hydroxy-benzamide-1,4,7-triazacyclononane (btacn), was successfully synthesized for first time comprehensively characterized. As expected, btacn exhibits high sensitive, nonspecific, extensive interaction with Cu2+, Co2+, Zn2+,...
Reported here are the design and fluorescence characters of a NiII/TbIII polymer, [Tb2Ni3(HCAM)6(H2O)12] n (1) (H3CAM = chelidamic acid). Under physiological conditions, binding biocompatible water soluble 1 to human serum albumin (HSA) was studied by spectroscopy techniques, which revealed that could inherent fluorescent light HSA in static quencher course change second-level structure. The marked enhancement its intensity provide conclusive evidence can play role "turn-on" sensor for...