A5101411853- Environmental DNA in Biodiversity Studies
- Microbial Community Ecology and Physiology
- RNA modifications and cancer
- Protist diversity and phylogeny
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Bacteriophages and microbial interactions
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Plant Stress Responses and Tolerance
- Plant-Microbe Interactions and Immunity
- Bacterial Genetics and Biotechnology
- Pregnancy and preeclampsia studies
- Plant Molecular Biology Research
- Genomics and Phylogenetic Studies
- Peripheral Artery Disease Management
- Antibiotic Resistance in Bacteria
- CRISPR and Genetic Engineering
- Stroke Rehabilitation and Recovery
- Plant and Fungal Interactions Research
- Angiogenesis and VEGF in Cancer
- Aquaculture disease management and microbiota
- Circular RNAs in diseases
- Gut microbiota and health
- RNA Research and Splicing
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Xiyuan Hospital
2022-2025
Dezhou University
2020-2025
Czech Academy of Sciences, Institute of Biophysics
2025
China Pharmaceutical University
2023-2025
Wageningen University & Research
2016-2024
Guangxi Medical University
2023-2024
Taizhou People's Hospital
2021-2024
Nantong University
2021-2024
Inner Mongolia University of Technology
2024
Summary In nature, plants have to cope with a wide range of stress conditions that often occur simultaneously or in sequence. To investigate how multi‐stress conditions, we analyzed the dynamics whole‐transcriptome profiles Arabidopsis thaliana exposed six sequential double stresses inflicted by combinations of: (i) infection necrotrophic fungus Botrytis cinerea , (ii) herbivory chewing larvae Pieris rapae and (iii) drought stress. Each these induced specific expression over time, which...
Summary Plants are exposed to combinations of various biotic and abiotic stresses, but stress responses usually investigated for single stresses only. Here, we the genetic architecture underlying plant 11 several their by phenotyping 350 Arabidopsis thaliana accessions. A set 214 000 nucleotide polymorphisms ( SNP s) was screened marker‐trait associations in genome‐wide association GWA ) analyses using tailored multi‐trait mixed models. Stress that share phytohormonal signaling pathways also...
In tomato, carotenoids are important with regard to major breeding traits such as fruit colour and human health. The enzyme phytoene synthase (PSY1) directs metabolic flux towards carotenoid synthesis. Through TILLING (Targeting Induced Local Lesions IN Genomes), we have identified two point mutations in the Psy1 gene. first mutation is a knockout allele (W180*) second leads an amino acid substitution (P192L). Plants carrying show yellow flesh similar r, r mutant, no further change during...
Long non-coding RNAs (lncRNAs) play important functional roles in many diverse biological processes. However, not all expressed lncRNAs are functional. Thus, it is necessary to manually collect experimentally validated (EVlncRNA) with their sequences, structures, and functions annotated a central database. The first release of such database (EVLncRNAs) was made using the literature prior 1 May 2016. Since then (till 15 2020), 19 245 articles related have been published. In EVLncRNAs 2.0,...
In nature, plants are exposed to biotic and abiotic stresses that often occur simultaneously. Therefore, plant responses combinations of most representative how respond stresses. We used RNAseq assess temporal changes in the transcriptome Arabidopsis thaliana herbivory by Pieris rapae caterpillars, either alone or combination with prior exposure drought infection necrotrophic fungus Botrytis cinerea. Pre-exposure stress resulted a significantly different timing caterpillar-induced...
This cross-sectional study aimed to investigate the association between TyG index and both obesity indicators hypertension among American adults. Data were drawn from 4,813 adults in 2013–2018 National Health Nutrition Examination Survey (NHANES). Multivariate logistic regression models indicated significant associations obesity-related indices with hypertension. Using Cox analysis, we examined relationship relation hypertensive prognosis, employing threshold effect analysis fitted smoothed...
By using the FAERS database, we aim to identify and assess risk signals of adverse drug events (ADEs) potentially causing pericardial effusion, inform clinical management promote rational use. We obtained reports effusion from database spanning first quarter 2004 second 2024, identified top 50 drugs ranked by report frequency or signal strength. Four algorithms, namely reported odds ratio (ROR), proportional reporting (PRR), Bayesian confidence propagation neural network (BCPNN), multi-item...
Abstract The biotic stress significantly influences the production of potato (Solanum tuberosum L.) all over world. Long noncoding RNAs (lncRNAs) play key roles in plant response to environmental stressors. However, their resistance pathogens, insects, and other are still unclear. PotatoBSLnc is a database for study lncRNAs major stress. Here, we collected 364 RNA sequencing (RNA-seq) data derived from 12 kinds stresses 26 cultivars wild potatoes. currently contains 18 636 44 263 mRNAs. In...
To use the FDA Adverse Event Reporting System (FAERS) database to identify drugs associated with orthostatic hypotension. event reports of hypotension from Q1 2004 Q3 2024 were obtained FAERS and JADER databases. We employed algorithms such as reporting odds ratio (ROR), proportional (PRR), Bayesian confidence propagation neural network (BCPNN), multi-item gamma Poisson shrinker (MGPS) for signal detection. was used validate findings analysis. identified 15,737 adverse events hypotension,...
<title>Abstract</title> Cyclic oligonucleotide-based antiphage signaling systems (CBASS) are widespread bacterial immune that trigger host suicide via cyclic nucleotide-activated effectors. The predominant strategy to induce cell death in CBASS is membrane disruption. Here, we demonstrate patatin-like phospholipase CapV, the most abundant effector, relocates and cleaves phospholipids at pole upon 3’3’-cGAMP binding, inducing polarized disruption death. Using cryo-EM, reveal apo-CapV adopts...
Objective Utilizing the FDA Adverse Event Reporting System (FAERS) database, this study conducts signal detection for drugs associated with cardiac arrest (CA), aiming to optimize clinical decision-making and ensure safer drug usage. Methods event reports related CA from first quarter of 2004 second 2024 were extracted FAERS database. Signal was conducted using reporting odds ratio (ROR) proportional (PRR) identify an increased risk CA. Results A total 66,431 analyzed, comprising 34,508...
The deep sea is one of the largest but least understood ecosystems on earth. Knowledge about diversity and distribution patterns as well drivers microbial eukaryote (including ciliates) along water column, particularly below photic zone, scarce. In this study, we investigated pelagic ciliates, main group marine microeukaryotes, their vertical from surface to abyssopelagic horizontal over a distance 1,300 km in Western Pacific Ocean, using high-throughput DNA cDNA (complementary DNA)...
Abstract Diversity assessments using the small subunit (SSU) rRNA gene allow for rapid of microeukaryotic communities. Yet, microeukaryotes, only limited information is available on extent to which sequence variations within individual genomes exist at this locus. We investigated 14 marine species belonging four major ciliate groups by single‐cell high‐throughput DNA sequencing estimate intragenomic polymorphism in V4 region SSU gene. Based these results, we evaluated potential effect...
Long noncoding RNAs (lncRNAs) have emerged as crucial regulators across diverse biological processes and diseases. While high-throughput sequencing has enabled lncRNA discovery, functional characterization remains limited. The EVLncRNAs database is the first exclusive repository for all experimentally validated lncRNAs from various species. After previous releases in 2018 2021, this update marks a major expansion through exhaustive manual curation of nearly 25 000 publications 15 May 2020,...
Preeclampsia (PE) is a complication during pregnancy that diagnosed by new onset of hypertension and proteinuria. Although the pathogenesis PE not fully understood, growing body evidence indicates oxidative stress mitochondrial dysfunction might contribute to progression PE. Therefore, aim present study was determine role mitophagy in PE, evaluate DNA damage‑regulated autophagy modulator 1 (DRAM1) development First, mouse model induced hypoxia‑inducible factor 1α established, high levels...
Abstract While the response of Arabidopsis thaliana to drought, herbivory or fungal infection has been well‐examined, consequences exposure a series such (a)biotic stresses are not well studied. This work reports on genetic mechanisms underlying single osmotic stress, and combinatorial either using Botrytis cinerea Pieris rapae caterpillars followed by an stress treatment. Several small‐effect loci associated with rosette dry weight (DW), water content (WC), projected leaf area in were...