A5100675746- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Immunotherapy and Immune Responses
- RNA modifications and cancer
- Advanced Glycation End Products research
- Connective Tissue Growth Factor Research
- Cancer, Hypoxia, and Metabolism
- Immune Response and Inflammation
- Oral Health Pathology and Treatment
- MicroRNA in disease regulation
- Wnt/β-catenin signaling in development and cancer
- TGF-β signaling in diseases
- Advanced battery technologies research
- DNA Repair Mechanisms
- Ubiquitin and proteasome pathways
- Coenzyme Q10 studies and effects
- Peptidase Inhibition and Analysis
- Natural product bioactivities and synthesis
- Circular RNAs in diseases
- Oral microbiology and periodontitis research
- Protease and Inhibitor Mechanisms
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Neurological Disease Mechanisms and Treatments
- Glutathione Transferases and Polymorphisms
Ningxia Medical University
2011-2025
China Pharmaceutical University
2022-2025
Huazhong University of Science and Technology
2023
Hubei Cancer Hospital
2023
State Key Laboratory of Medical Neurobiology
2023
Western Laboratories (United States)
2023
Eye & ENT Hospital of Fudan University
2023
Sichuan University
2009-2021
Guangxi Medical University
2021
Changchun University of Chinese Medicine
2021
An increased population of CD4+CD25highFoxp3+ regulatory T cells (Tregs) in the tumor-associated microenvironment plays an important role cancer immune evasion. However, underlying mechanism remains unclear. Here we observed secretion miR-214 various types human cancers and mouse tumor models. Tumor-secreted was sufficiently delivered into recipient by microvesicles (MVs). In targeted peripheral CD4+ cells, tumor-derived efficiently downregulated phosphatase tensin homolog (PTEN) promoted...
PD-L1 up-regulation in cancer contributes to immune evasion by tumor cells. Here, we show that Wnt ligand and activated EGFR induce the binding of β-catenin/TCF/LEF complex CD274 gene promoter region expression, which AKT activation plays an important role. β-Catenin depletion, inhibition, or PTEN expression reduces cells, enhances infiltration CD8+ T growth, accompanied prolonged mouse survival. Combined treatment with a clinically available inhibitor anti–PD-1 antibody overcomes greatly...
Abstract There is no agnostic GWAS evidence for the genetic control of IL-1β expression in periodontal disease. Here we report a “high” gingival crevicular fluid among 4910 European-American adults and identify association signals IL37 locus. rs3811046 at this locus ( p = 3.3 × 10 −22 ) associated with severe chronic periodontitis (OR 1.50; 95% CI 1.12–2.00), 10-year incident tooth loss (≥3 teeth: RR 1.33; 1.09–1.62) aggressive 1.12; 1.01–1.26) an independent sample 4927 German/Dutch adults....
Periodontitis is one of the most prevalent chronic inflammatory diseases and induced by interaction between oral microorganisms host immune system. Plasma cells are special interest in periodontitis (CP), as they represent ~50% infiltrated periodontal lesions. constitute only known cell type capable antibody production; however, recent evidence supports an emerging role for distinct sets plasma cytokine production. However, presence cytokine-producing CP unknown. In this study, we used...
Abstract Skin diseases encompass a diverse range of conditions with significant psychological and physiological impacts. N6-methyladenosine (m6A) RNA methylation is key epitranscriptomic modification that regulates gene expression by influencing stability, splicing, translation, export, degradation. Recent studies have highlighted the crucial role m6A in pathogenesis progression various skin diseases. M6A affects critical biological processes skin, such as inflammation, immune response,...
<title>Abstract</title> Cyclic oligonucleotide-based antiphage signaling systems (CBASS) are widespread bacterial immune that trigger host suicide via cyclic nucleotide-activated effectors. The predominant strategy to induce cell death in CBASS is membrane disruption. Here, we demonstrate patatin-like phospholipase CapV, the most abundant effector, relocates and cleaves phospholipids at pole upon 3’3’-cGAMP binding, inducing polarized disruption death. Using cryo-EM, reveal apo-CapV adopts...
The development of chemoresistance to cisplatin regimens causes a poor prognosis in patients with advanced NSCLC. role noncanonical Wnt signaling the regulation properties lung cancer stem cells and was interrogated, by accessing capacities cell proliferation, migration, invasion, clonogenicity as well apoptosis A549 lines cisplatin-resistant treated Wnt5a conditional medium or protein kinase C (PKC) inhibitor GF109203X. Results showed that ligand, Wnt5a, could promote colony formation...
This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology. Postmenopausal osteoporosis (PMOP), which increases risk fracture, is most common bone disease women. PMOP not only death but also imposes financial burden on countless families. At present, drugs used treat have significant side effects, so it important find effective anti-osteoporosis medications without major effects. Sesamolin (Ses) kind natural lignan extracted...
Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor that regulates the cellular adaptation to hypoxia. HIF-1α gene single nucleotide polymorphisms (SNPs) are implicated be associated with cancer risks. However, results from published studies remained inconclusive. The aim of this study investigate relationship G1790A polymorphism using meta-analysis.A comprehensive search in Pubmed, EMBASE and China National Knowledge Infrastructure (CNKI) was conducted identify all publications...
Abstract Interleukin 37 (IL-37) has been reported to play a significant role in innate immune response and be involved several kinds of cancers. However, the investigation association between IL-37 oral mucosa carcinogenesis hasn't clearly established. The aim study was assess expression explore its carcinogenesis. increased from normal control (NC) Oral leukoplakia (OLK) squamous cell carcinoma (OSCC). Moreover, statistically highly difference present scores OLK with without mild/moderate...
Deletion of mitochondrial uncoupling protein 2 (UCP2) has been shown to aggravate ischemic damage in the brain.However, underlying mechanisms are not fully understood.The objective this study is explore impact homozygous UCP2 deletion (UCP2 -/-) on fission and fusion dynamic balance mice under normo-and hyperglycemic conditions.UCP2 -/-and wildtype were subjected a 60 min middle cerebral artery occlusion (MCAO) allowed reperfusion for 6h, 24h 72h.Our results demonstrated that enlarged...
Ultraviolet B (UVB) induces cell death by increasing free radical production, activating apoptotic pathways and depolarizing mitochondrial membrane potential. Coenzyme Q10 (CoQ10), an essential cofactor in the electron transport chain, serves as a potent antioxidant mitochondria. The aim of present study is to establish whether CoQ10 capable protecting neuronal cells against UVB-induced damage. Murine hippocampal HT22 were treated with 0.01, 0.1 or 1 µM 3 24 h prior being exposed UVB...
This study investigates whether Wnt components play a role in carcinogenesis, or the invasion and metastasis of salivary glands, also referred to as adenoid cystic carcinoma (sAdCC).Several sAdCC cell lines with low invasive potential (ACC-2), high metastatic (ACC-M), higher (T-ACC-M) were examined determine correlate tumors' behavior.Immunohistochemistry was performed tissue array.ACC-M expressed levels Wnt-1, beta-catenin lower WIF-1 compared ACC-2 (P<0.05).T-ACC-M exhibited increased mRNA...
Despite recent advances in oral squamous cell carcinoma (OSCC) diagnosis and therapy, disease recurrence remains common is strongly associated with mortality. It therefore critical to identify new targets for both treatment diagnostic purposes. We aimed at investigating the role of PA28α, a proteasomal activator OSCC.The expression PA28α was examined panel OSCC lines tissues, oncomine analysis. In large patient cohort, prognostic value evaluated. Primary clinical end points were...
The increased prevalence of obesity and type 2 diabetes (T2D) has become an important factor affecting the health human. Obesity is commonly considered as a major risk for development T2D. However, molecular mechanisms disease relations are not well discovered yet. In this study, combination multiple differential expression profiles comprehensive biological network T2D allowed us to identify compare disease-responsive active modules subclusters. results demonstrated that connection between...