A5034782971- Oral microbiology and periodontitis research
- Dental Health and Care Utilization
- Dental Radiography and Imaging
- Oral Health Pathology and Treatment
- HIV/AIDS oral health manifestations
- Pregnancy and preeclampsia studies
- Salivary Gland Disorders and Functions
- Cerebrovascular and Carotid Artery Diseases
- Cleft Lip and Palate Research
- Oral and gingival health research
- Gestational Diabetes Research and Management
- Pediatric health and respiratory diseases
- Streptococcal Infections and Treatments
- Immune Response and Inflammation
- Birth, Development, and Health
- Acute Ischemic Stroke Management
- Preterm Birth and Chorioamnionitis
- Orthodontics and Dentofacial Orthopedics
- Infant Nutrition and Health
- Dental Research and COVID-19
- Neonatal Respiratory Health Research
- Dental Erosion and Treatment
- Phonetics and Phonology Research
- Dental materials and restorations
- Inflammasome and immune disorders
University of North Carolina at Chapel Hill
2016-2025
Indiana University – Purdue University Indianapolis
2024-2025
Indiana University School of Medicine
2024-2025
East Carolina University
2025
Pulse Biosciences (United States)
2021-2024
Indiana University
2024
University School
2024
Indiana University Indianapolis
2024
Indiana University Bloomington
2024
Tufts University
2021
In Brief OBJECTIVE: The goal was to estimate whether maternal periodontal disease predictive of preterm (less than 37 weeks) or very 32 births. METHODS: A prospective study obstetric outcomes, entitled Oral Conditions and Pregnancy (OCAP), conducted with 1,020 pregnant women who received both an antepartum postpartum examination. Predictive models were developed exposure either at enrollment 26 and/or progression during pregnancy, as determined by comparing status, births, adjusting for risk...
Background— Results from studies relating periodontal disease to cardiovascular have been mixed. Residual confounding by smoking and use of clinical measures rather than infection 2 major criticisms. The aims this study were investigate relationships between prevalent coronary heart (CHD) exposures, (1) (2) IgG antibodies 17 oral organisms, evaluate the role in these relationships. Methods Results— Our is based on a subset participants Atherosclerosis Risk Communities (ARIC) Study, who...
Chronic periodontitis (CP) is a common oral disease that confers substantial systemic inflammatory and microbial burden major cause of tooth loss. Here, we present the results genome-wide association study CP was carried out in cohort 4504 European Americans (EA) participating Atherosclerosis Risk Communities (ARIC) Study (mean age-62 years, moderate CP-43% severe CP-17%). We detected no significant signals for CP; however, found suggestive evidence (P < 5 × 10(-6)) six loci, including NIN,...
Background and Purpose— Periodontal disease is independently associated with cardiovascular disease. Identification of periodontal as a risk factor for incident ischemic stroke raises the possibility that regular dental care utilization may reduce risk. Methods— In ARIC (Atherosclerosis Risk in Communities) study, pattern visits were classified or episodic users. ancillary selected subjects from underwent fullmouth measurements collected at 6 sites per tooth into 7 profile classes (PPCs)....
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we report that the clotting factor fibrin is a regulator of neutrophil function oral barrier. We demonstrate commensal microbiota trigger extravascular deposition in mucosa. Fibrin engages neutrophils through α
OBJECTIVE: To determine if maternal periodontal disease is associated with the development of preeclampsia. METHODS: A cohort 1115 healthy pregnant women were enrolled at less than 26 weeks' gestation and followed until delivery. Maternal demographic medical data collected. Periodontal examinations performed enrollment within 48 hours delivery to presence severe or progression. Preeclampsia was defined as blood pressure greater 140/90 on two separate occasions, least 1+ proteinuria...
A molecular epidemiologic study provided the opportunity to characterize biology of biofilm-gingival interface (BGI) in 6,768 community-dwelling subjects.Disease classifications and multivariable models were developed using clinical, microbial, inflammatory, host-response data. The purpose was identify new clinical categories that represented distinct biologic phenotypes based upon DNA checkerboard analyses eight plaque bacteria, serum immunoglobulin G (IgG) titers 17 gingival crevicular...
Background: In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac–dental centers. Methods: Subjects were randomized to either community care or protocol scaling root planing evaluate effects on status systemic levels of high‐sensitivity C‐reactive protein (hs‐CRP). Results: After 6 months, there significant reduction mean probing depth extent 4‐ 5‐mm...
Background: Few studies have examined the potential effects of periodontal treatment during pregnancy on outcomes, status, and inflammatory biomarkers. Methods: A randomized, delayed‐treatment, controlled pilot trial was conducted to evaluate second‐trimester scaling root planing use a sonic toothbrush rate preterm delivery (<37 weeks gestation). Secondary outcome measures included changes in levels eight oral pathogens, gingival crevicular fluid (GCF) interleukin‐1β (IL‐1β),...
Background: Our objective was to describe the oral health of pregnant women, determine changes during pregnancy, and factors associated with maternal periodontal or disease. Materials Methods: Between December 1997 July 2001, 1,224 women at <26 weeks’ gestation were enrolled in study examinations performed enrollment within 48 hours delivery. Demographic, medical, behavior data determined by chart abstraction questionnaire. Comparisons between delivery made student t test Fisher's exact...
Pathological shifts of the human microbiome are characteristic many diseases, including chronic periodontitis. To date, there is limited evidence on host genetic risk loci associated with periodontal pathogen colonization. We conducted a genome-wide association (GWA) study among 1,020 white participants Atherosclerosis Risk in Communities Study, whose diagnosis ranged from healthy to severe periodontitis, and for whom “checkerboard” DNA-DNA hybridization quantification 8 pathogens was...
Genome-wide association studies (GWAS) of chronic periodontitis (CP) defined by clinical criteria alone have had modest success to-date. Here, we refine the CP phenotype supplementing data with biological intermediates microbial burden (levels eight periodontal pathogens) and local inflammatory response (gingival crevicular fluid IL-1β) derive complex traits (PCTs) via principal component analysis. PCTs were carried forward to GWAS (∼2.5 million markers) identify PCT-associated loci among...
Recent genome-wide association studies (GWAS) of chronic periodontitis (CP) offer rich data sources for the investigation candidate genes, functional elements, and pathways. We used GWAS CP ( n = 4,504) periodontal pathogen colonization 1,020) from a cohort adult Americans European descent participating in Atherosclerosis Risk Communities study employed MAGENTA approach i.e., meta-analysis gene set enrichment variant associations) to obtain gene-centric results corrected size, number...
Few studies examining the association between periodontal diseases and preterm birth have explored underlying microbial antibody responses associated with oral infection.A nested case-control study was performed using data from a recent interventional trial following delayed-treatment control group of 31 subjects diseases. The levels eight bacteria maternal immunoglobulin G (IgG) in serum to these were measured at antepartum postpartum visits determine relationship cases (preterm delivery...
The goal of this study is to characterize the changes in 33 biomarkers within gingival crevicular fluid during 3-week induction and 4-week resolution stent-induced, biofilm overgrowth mediated, experimental gingivitis humans.Experimental was induced 25 subjects for 21 days followed by treatment with a sonic powered toothbrush 28 days. Clinical indices fluids were collected weekly biweekly resolution. Samples analysed using bead-based multiplexing analysis simultaneous measurements each...
Maternal periodontal disease is found in < or = 40% of pregnant women and associated with adverse pregnancy outcomes. Vitamin D deficiency may play a role tooth loss, insufficient vitamin status common among women. The objective this study to examine the relationship between maternal disease.A case-control was conducted. Cases were defined as clinical moderate severe disease; controls who periodontally healthy. data chart abstracted serum collected 14 26 weeks gestation. Serum...
Abstract Background This paper focuses on the Periodontal Profile Class (PPC) System that may be more informative and representative of periodontitis phenotypes than current case definitions periodontitis. study illustrates unique aspects PPC compared with other periodontal indices for studying associations between disease prevalent systemic conditions. Methods We computed odds ratios 95% confidence intervals to compare conditions using our new two traditional indices. used Bayesian...