A5006120911- Oral microbiology and periodontitis research
- Oral Health Pathology and Treatment
- Dental Health and Care Utilization
- Genetic Associations and Epidemiology
- Streptococcal Infections and Treatments
- Genomics and Rare Diseases
- Cleft Lip and Palate Research
- Helicobacter pylori-related gastroenterology studies
- Genetics and Neurodevelopmental Disorders
- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Oral and gingival health research
- BRCA gene mutations in cancer
- dental development and anomalies
- Infective Endocarditis Diagnosis and Management
- Neurological diseases and metabolism
- Cardiomyopathy and Myosin Studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Immune Response and Inflammation
- Diabetes Treatment and Management
- Inflammatory mediators and NSAID effects
- Peptidase Inhibition and Analysis
- Hepatitis C virus research
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
University of North Carolina at Chapel Hill
2016-2021
North Carolina State University
2017-2019
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we report that the clotting factor fibrin is a regulator of neutrophil function oral barrier. We demonstrate commensal microbiota trigger extravascular deposition in mucosa. Fibrin engages neutrophils through α
Abstract There is no agnostic GWAS evidence for the genetic control of IL-1β expression in periodontal disease. Here we report a “high” gingival crevicular fluid among 4910 European-American adults and identify association signals IL37 locus. rs3811046 at this locus ( p = 3.3 × 10 −22 ) associated with severe chronic periodontitis (OR 1.50; 95% CI 1.12–2.00), 10-year incident tooth loss (≥3 teeth: RR 1.33; 1.09–1.62) aggressive 1.12; 1.01–1.26) an independent sample 4927 German/Dutch adults....
Chronic periodontitis (CP) has a genetic component, particularly its severe forms. Evidence from genome-wide association studies (GWASs) highlighted several potential novel loci. Here, the authors report first GWAS of CP among large community-based sample Hispanics/Latinos. The interrogated quantitative trait (mean interproximal clinical attachment level determined by full-mouth periodontal examinations) 10,935 adult participants age: 45 y, range: 18 to 76 y) Hispanic Community Health Study...
Objective A genetic component in early childhood caries ( ECC ) is theorized, but no genome‐wide investigations of have been conducted. This pilot study part a long‐term research program aimed to: (1) determine the proportion variance attributable to human genome and (2) identify ‐associated loci. Methods The study's community‐based sample comprised 212 children (mean age=39 months; range = 30–52 males 55%; Hispanic/Latino 35%, African‐American 32%; American Academy Pediatric Dentistry...
Early childhood caries (ECC) is an aggressive form of dental occurring in the first five years life. Despite its prevalence and consequences, little progress has been made prevention even less known about individuals’ susceptibility or genomic risk factors. The genome-wide association study (GWAS) ECC (“ZOE 2.0”) a community-based, multi-ethnic, cross-sectional, genetic epidemiologic seeking to address this knowledge gap. This paper describes study’s design, cohort’s demographic profile,...
An increasing body of evidence suggests a significant genetic regulation inflammatory response mechanisms; however, little is known regarding the determinants severe gingival inflammation (GI). We conducted genome-wide association study GI among 4,077 European American adults, participants in Dental Atherosclerosis Risk Communities cohort. The trait was defined dichotomously with 90th percentile index ≥2 extent score. Genotyping performed Affymetrix 6.0 array platform, and an imputed set 2.5...
Background Scottish Terriers have a high incidence of juvenile onset hereditary ataxia primarily affecting the Purkinje neuron cerebellar cortex and causing slowly progressive dysfunction. Objective To identify chromosomal regions associated with in Terriers. Animals One hundred fifty‐three were recruited through Terrier Club America. Materials Methods Prospective study. Dogs classified as affected if they had signs. When possible, magnetic resonance imaging histopathological evaluation...
Abstract Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we document that the clotting factor fibrin is a regulator of neutrophil function We demonstrate engages neutrophils through α M β 2 integrin receptor and activates effector functions, including production reactive oxygen species NET formation. These immune-protective functions become tissue damaging in context impaired plasmin-mediated fibrinolysis. Indeed, accumulation due to Mendelian genetic defects...