A5068521866- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Acoustic Wave Resonator Technologies
- Electrowetting and Microfluidic Technologies
- Microwave and Dielectric Measurement Techniques
- Oral microbiology and periodontitis research
- Electrohydrodynamics and Fluid Dynamics
- Advanced Fiber Optic Sensors
- Ferroelectric and Piezoelectric Materials
- Photonic and Optical Devices
- Advancements in Transdermal Drug Delivery
- Semiconductor Lasers and Optical Devices
- Advanced MEMS and NEMS Technologies
- Microwave Engineering and Waveguides
- 3D Printing in Biomedical Research
- Micro and Nano Robotics
- Pickering emulsions and particle stabilization
- Analytical Chemistry and Chromatography
- Modular Robots and Swarm Intelligence
- Lipid Membrane Structure and Behavior
- HIV/AIDS oral health manifestations
- Microwave-Assisted Synthesis and Applications
- Dielectric materials and actuators
- Dental Health and Care Utilization
Cardiff University
2016-2025
University of North Carolina at Chapel Hill
2006-2021
University of North Carolina System
2006-2018
University of North Carolina Health Care
2013
University of Puerto Rico at Carolina
2011
Queen's University
1991-2002
Microsystems (United Kingdom)
2002
Baylor College of Medicine
2002
Datec Coating (Canada)
1995-2001
University of Wales
1993-2001
In this paper, a new type of microwave microfluidic sensor is proposed to detect and determine the dielectric properties common liquids. The technique based on perturbation theory, in which resonant frequency quality factor resonator depend resonator. A microstrip split-ring with two gaps adopted for design sensors (i.e., double resonator). This both compact planar, making it suitable lab-on-a-chip approach. Several types solvents are tested capillaries verify performance. At 3 GHz, very...
Lead zirconate titanate (PZT) films 60 μm in thickness have been fabricated using a new sol gel based process. PZT powders are dispersed matrix to form 0–3 ceramic/ceramic composite. The dielectric properties of these studied as function powder concentration, frequency, and temperature. characteristic Curie point is observed at 420 °C. ferroelectric behavior measured terms the remanant polarization (Pr=35 μC/cm2) coercive field (Ec=20 kV/cm) was an improvement over values quoted for thin but...
Background: In the Periodontitis and Vascular Events (PAVE) pilot study, periodontal therapy was provided as an intervention in a secondary cardiac event prevention model through five coordinated cardiac–dental centers. Methods: Subjects were randomized to either community care or protocol scaling root planing evaluate effects on status systemic levels of high‐sensitivity C‐reactive protein (hs‐CRP). Results: After 6 months, there significant reduction mean probing depth extent 4‐ 5‐mm...
Background: Few studies have examined the potential effects of periodontal treatment during pregnancy on outcomes, status, and inflammatory biomarkers. Methods: A randomized, delayed‐treatment, controlled pilot trial was conducted to evaluate second‐trimester scaling root planing use a sonic toothbrush rate preterm delivery (<37 weeks gestation). Secondary outcome measures included changes in levels eight oral pathogens, gingival crevicular fluid (GCF) interleukin‐1β (IL‐1β),...
Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with antinociceptive pronociceptive properties. We conducted a randomized, single-blinded, parallel-group clinical trial assess biochemical effects of targeted alteration in dietary n-3 for treatment chronic headaches. After 4-week preintervention phase, ambulatory patients daily headache undergoing usual care were randomized 1 2 intensive, food-based 12-week interventions: high plus low (H3-L6) intervention, or (L6)...
The uptake of microfluidics by the wider scientific community has been limited fabrication barrier created skills and equipment required for production traditional microfluidic devices. Here we present simple 3D printed devices using an inexpensive readily accessible printer with commercially available materials. We demonstrate that previously reported limitations transparency fidelity have overcome, whilst capable operating at pressures in excess 2000 kPa illustrate leakage issues also...
We present a method of making low-loss split-ring resonators (SRRs) for microfluidic sensing at microwave frequencies using silver-coated copper wire. show that simple geometric modification and the use square cross-section wire give greater electric field confinement in capacitive region resonant sensor. combination theoretical analysis, finite-element simulations, empirical measurements to demonstrate subsequent increases sensitivity these SRRs complex permittivity some common solvents.
Abstract Objective To determine whether dietary interventions that increase n-3 fatty acids with and without reduction in n-6 linoleic acid can alter circulating lipid mediators implicated headache pathogenesis, decrease adults migraine. Design Three arm, parallel group, randomized, modified double blind, controlled trial. Setting Ambulatory, academic medical center the United States over 16 weeks. Participants 182 participants (88% women, mean age 38 years) migraines on 5-20 days per month...
Intracellular compartments are functional units that support the metabolism within living cells, through spatiotemporal regulation of chemical reactions and biological processes. Consequently, as a step forward in bottom-up creation artificial building analogous intracellular architectures is essential for expansion cell-mimicking functionality. Herein, we report development droplet laboratory platform to engineer complex emulsion-based, multicompartment using microfluidics acoustic...
Abstract For a simple biphasic hydrolysis, we show that the application of various reaction conditions in microreactors using segmented flow can dramatically increase rate. A tandem diazotation/Heck served as an example even homogeneous reactions be accelerated by segmentation microreactors.
Multifactorial etiological factors contribute to denture stomatitis (DS), a type of oral candidiasis; however, unlike other candidiasis, DS can occur in healthy person wearing denture. In this study, we therefore attempt explore the association between candida, denture, and mucosal tissue using (1) exfoliative cytology, (2) candidal levels present saliva, on tissues surfaces, (3) salivary flow rate xerostomic symptoms.A cross-sectional study enrolled 32 edentulous participants, 17 without as...
The stratum corneum (SC) represents a significant barrier to the delivery of gene therapy formulations. In order realise potential therapeutic cutaneous transfer, strategies are required overcome this exclusion effect. This study investigates ability microfabricated silicon microneedle arrays create micron-sized channels through SC ex vivo human skin and resulting conduits facilitate localised charged macromolecules plasmid DNA (pDNA). Microscopic studies microneedle-treated epidermal...
Biomicroelectromechanical systems (bio-MEMS) are MEMS which designed for medical or biological applications. As with other MEMS, bio-MEMS frequently, have to be packaged provide an interface the macroscale world of user. Bio-MEMS can roughly divided in two groups. pure technical applied a environment integrate materials as one functional component system. In both cases, intimate contact matter biocompatible avoid unintentional effects on substances, case implants, could harm patient....
Capillary forces on the microscale are exploited to create a continuous flow liquid–liquid phase separator. Segmented regimes of immiscible fluids generated and subsequently separated into their component phases through an array high aspect ratio, laser machined, separation ducts (36 µm wide, 130 deep) in planar, integrated, polytetrafluoroethylene (PTFE) microdevice. A controlled pressure differential across separator architecture facilitates selective passage wetting, organic, ducts,...
The ability to make artificial lipid bilayers compatible with a wide range of environments, and sufficient structural rigidity for manual handling, would open up wealth opportunities their more routine use in real-world applications. Although droplet interface (DIBs) have been demonstrated host laboratory applications, from chemical logic biosynthesis reaction vessels, wider is hampered by lack mechanical stability the largely methods employed production. Multiphase microfluidics has enabled...
Abstract Background: Social stressors, such as social relationship deficits, have been increasingly linked to chronic disease outcomes, including cancer. However, critical gaps exist in our understanding of the nature and strength links, well underlying biological mechanisms relating relationships cancer progression survival. Methods: Utilizing novel questionnaire biomarker data from UNC Health Registry/Cancer Survivorship Cohort, this study examines associations between diverse measures...
The bottom-up construction of synthetic cells with user-defined chemical organization holds considerable promise in the creation bioinspired materials. Complex emulsions, droplet networks, and nested vesicles all represent platforms for engineering segregated chemistries controlled communication, analogous to biological cells. Microfluidic manufacture such droplet-based materials typically results radial or axisymmetric structures. In contrast, frequently display polarity gradients, which...
Stem cell encapsulation technology demonstrates much promise for the replacement of damaged tissue in several diseases, including spinal cord injury (SCI). The use biocompatible microcapsules permits control stem fate situ to facilitate damaged/lost tissue. In this work, a novel customized microfluidic device was developed reproducible neural cells (NSCs) and dental pulp (DPSCs) within monodisperse, alginate-collagen microcapsules. Both types survived up 21 days culture. demonstrated...