A5046261217- Fatty Acid Research and Health
- Antioxidant Activity and Oxidative Stress
- Eicosanoids and Hypertension Pharmacology
- Birth, Development, and Health
- Advanced Glycation End Products research
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Hemodynamic Monitoring and Therapy
- Metabolomics and Mass Spectrometry Studies
- Diabetes Management and Research
- Free Radicals and Antioxidants
- Alzheimer's disease research and treatments
- Renal function and acid-base balance
- Inflammatory mediators and NSAID effects
- Pregnancy and preeclampsia studies
- Acute Kidney Injury Research
- Nausea and vomiting management
- Diet, Metabolism, and Disease
- Blood Pressure and Hypertension Studies
- Coenzyme Q10 studies and effects
- Adipose Tissue and Metabolism
- Traumatic Brain Injury and Neurovascular Disturbances
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Ischemia and Reperfusion
- Natural Antidiabetic Agents Studies
The University of Adelaide
2022-2024
Women's and Children's Hospital
2022-2024
South Australia Pathology
2020-2024
The University of Western Australia
2010-2020
Royal Perth Hospital
2010-2020
Hôpital Lapeyronie
2001-2012
Inserm
2009
University of Lausanne
2009
Institute of Clinical Research
2009
Université de Montpellier
2005
Glycemic disorders, one of the main risk factors for cardiovascular disease, are associated with activation oxidative stress.To assess respective contributions sustained chronic hyperglycemia and acute glucose fluctuations to stress in type 2 diabetes.Case-control study 21 patients diabetes (studied 2003-2005) compared age- sex-matched controls 2001) Montpellier, France.Oxidative stress, estimated from 24-hour urinary excretion rates free 8-iso prostaglandin F2alpha (8-iso PGF2alpha)....
Abstract BACKGROUND Resolvins and protectins are families of local lipid mediators generated from the n-3 fatty acids eicosapentaenoic acid (EPA) docosahexaenoic (DHA) during self-limited resolution inflammation. We aimed to develop a liquid chromatography–tandem mass spectrometry (LC-MS/MS) assay measure these in human blood following supplementation determine whether collection method affects their measured concentration. METHODS Blood samples 20 healthy volunteers enrolled an trial were...
Omega-3 and n-6 fatty acids are biosynthetic precursors to lipid mediators with antinociceptive pronociceptive properties. We conducted a randomized, single-blinded, parallel-group clinical trial assess biochemical effects of targeted alteration in dietary n-3 for treatment chronic headaches. After 4-week preintervention phase, ambulatory patients daily headache undergoing usual care were randomized 1 2 intensive, food-based 12-week interventions: high plus low (H3-L6) intervention, or (L6)...
There is mounting evidence that specific dietary polyphenols can enhance vascular health by augmenting nitric oxide. Our aim was to investigate the acute effects of chlorogenic acid, an important phenolic acid present in coffee (400 mg, equivalent 2 cups coffee), on oxide status, endothelial function, and blood pressure. Healthy men women (n = 23) were recruited a randomized, double-blind, placebo-controlled, crossover trial. Chlorogenic resulted significantly higher plasma concentrations (P...
In May 2006, a 28-year-old woman abruptly experienced excessive daytime sleepiness (EDS) and 2 to 3 short, refreshing but irresistible naps per day. She also reported increased nighttime sleep duration of more than hours. Her Epworth Sleepiness Scale score was 22, indicating severe sleepiness. developed clear-cut generalized partial cataplexy provoked by laughter stress with frequency 1 attack A rapid large weight gain noted up 6 kg within weeks, without clear change in appetite. never...
Omega-3 (ω3) fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic (DHA), protect against cardiovascular disease. Despite these benefits, concern remains that ω3 acids may increase lipid peroxidation. It has previously been shown urinary F2-isoprostanes (F2-IsoPs) were reduced following supplementation in humans. is now determined whether EPA or DHA affects plasma F2-IsoPs. In two 6-week placebo-controlled interventions, Study A: overweight, dyslipidaemic men; B:...
The aim of this study was to determine whether supplementation with fish oil-derived n-3 polyunsaturated fatty acids (n-3 PUFA) during pregnancy modifies placental PUFA composition, the accumulation specialised pro-resolving lipid mediators (SPMs, specifically resolvins (Rv), protectins (PD) and upstream precursors) inflammatory gene expression. Placentas were collected from women (n=51) enrolled in a randomised, placebo controlled trial 20-week gestation. Lipids extracted for acid analysis...
Resolution of inflammation is an active process involving specialized proresolving mediators (SPM) formed from the n-3 fatty acids. This study examined effect acid supplementation and aspirin on plasma SPMs in healthy humans. Healthy volunteers (n = 21) were supplemented with acids (2.4g/day) for 7 days random assignment to take (300 mg/day) or placebo day 5 7. Blood was collected at baseline (day 0), 5, Plasma 18R/S-HEPE, E-series resolvins, 17R/S-HDHA, D-series 14R/S-HDHA, MaR-1 measured...
Placental inflammation is associated with several pregnancy disorders. Inflammation limited by anti-inflammatory and proresolving mechanisms, the latter partly mediated resolvins protectins derived from omega-3 polyunsaturated fatty acids (n-3PUFA). We examined effects of dietary n-3PUFAs on levels resolvins, protectins, lipoxygenase (ALOX) enzymes in rat placenta. Rats consumed standard (Std) or high n-3PUFA (Hn3) diets day 1 pregnancy; tissues were collected 17 22 (term = 23). Maternal Hn3...
The metabolic syndrome (MetS) is associated with a chronic low-grade inflammatory state and may be affected by the ability to resolve inflammation, which an active process that involves specialized proresolving lipid mediators (SPMs) derived from n-3 (ω-3) fatty acids. We compared plasma concentrations of SPMs in men women features MetS healthy matched control subjects response intakes acids aspirin. volunteers (n = 22) healthy, controls 21) were studied parallel for 4 wk. Both groups took...
Resolution of inflammation is an active process involving specialised pro-resolving mediators (SPM) generated from the n-3 fatty acids EPA and DHA. Fatty acid supplementation during pregnancy may provide intervention strategy to modify these novel SPM. This study aimed assess effect in on offspring SPM at birth 12 years age (12 years). In all, ninety-eight atopic pregnant women were randomised 3·7 g daily or a control (olive oil), 20 weeks gestation until delivery. Blood was collected years....