A5052104436- Diabetes Management and Research
- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Diabetes and associated disorders
- Metabolism, Diabetes, and Cancer
- Pancreatic function and diabetes
- Nutritional Studies and Diet
- Pharmacology and Obesity Treatment
- Lipoproteins and Cardiovascular Health
- Dietary Effects on Health
- Health, Medicine and Society
- Diabetes Management and Education
- Nitric Oxide and Endothelin Effects
- Diet, Metabolism, and Disease
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Antioxidant Activity and Oxidative Stress
- Vitamin D Research Studies
- Cardiovascular Function and Risk Factors
- Peroxisome Proliferator-Activated Receptors
- Regulation of Appetite and Obesity
- Fatty Acid Research and Health
- Healthcare Systems and Practices
- Vitamin C and Antioxidants Research
- Consumer Attitudes and Food Labeling
Université de Montpellier
2015-2024
Institut Universitaire de Recherche Clinique
2011-2020
Université Paul-Valéry Montpellier
2020
RELX Group (Netherlands)
2019
Past Global Changes
2019
Institut de Recherche pour le Développement
2018
Centre Hospitalier Universitaire de Montpellier
1997-2018
Neuropsychiatrie : Recherche Epidemiologique et Clinique
2015
Institut de Génétique Humaine
2013
Hôpital Lapeyronie
2001-2012
Glycemic disorders, one of the main risk factors for cardiovascular disease, are associated with activation oxidative stress.To assess respective contributions sustained chronic hyperglycemia and acute glucose fluctuations to stress in type 2 diabetes.Case-control study 21 patients diabetes (studied 2003-2005) compared age- sex-matched controls 2001) Montpellier, France.Oxidative stress, estimated from 24-hour urinary excretion rates free 8-iso prostaglandin F2alpha (8-iso PGF2alpha)....
The exact contributions of postprandial and fasting glucose increments to overall hyperglycemia remain controversial. discrepancies between the data published previously might be caused by interference several factors. To test effect glycemic control itself, we analyzed diurnal profiles type 2 diabetic patients investigated at different levels HbA(1c).In 290 non-insulin- non-acarbose-using with diabetes, plasma (PG) concentrations were determined (8:00 A.M.) during postabsorptive periods (at...
The aim of the study was to determine whether loss fasting and postprandial glycemic control occurs in parallel or sequentially evolution type 2 diabetes.In 130 diabetic patients, 24-h glucose profiles were obtained using a continuous monitoring system. individuals with diabetes divided into five groups according A1C levels: 1 (<6.5%, n = 30), (6.5-6.9%, 17), 3 (7-7.9%, 32), 4 (8-8.9%, 25), 5 (> =9%, 26). between compared. overall concentrations for diurnal, nocturnal, morning periods, which...
To define the threshold for excess glucose variability (GV), one of main features dysglycemia in diabetes.A total 376 persons with diabetes investigated at University Hospital Montpellier (Montpellier, France) underwent continuous monitoring. Participants type 2 were divided into several groups-groups 1, 2a, 2b, and 3 (n = 82, 28, 65, 79, respectively)-according to treatment: 1) diet and/or insulin sensitizers alone; 2) oral therapy including an insulinotropic agent, dipeptidyl peptidase 4...
OBJECTIVE To evaluate the relative value of plasma glucose (PG) at different time points in assessing control type 2 diabetic patients. RESEARCH DESIGN AND METHODS Glycemic profiles, i.e., PG prebreakfast (8:00 A.M.), prelunch (11:00 postlunch (2:00 P.M.), and extended (5:00 P.M.) times over same day, were obtained 66 patients on an ambulatory basis. The compared with a measurement HbA1c made reference laboratory. RESULTS Extended was lower than (104 ± 21 vs. 133 35 mg/dl, P &lt; 0.02)...
The dysglycemia of diabetes includes two components: (1) sustained chronic hyperglycemia that exerts its effects through both excessive protein glycation and activation oxidative stress (2) acute glucose fluctuations. Glycemic variability seems to have more deleterious than in the development diabetic complications as upward (postprandial increments) downward (interprandial decrements) changes activate stress. For instance, urinary excretion rate 8-iso-PGF2α, a reliable marker stress, was...
Diabetes is characterized by glycemic disorders that include both sustained chronic hyperglycemia and acute glucose fluctuations. There now cogent evidence for the deleterious effects of results in excessive protein glycation generation oxidative stress. The role variability from peaks to nadirs less documented, but there are many reasons think upward (postprandial) downward (interprandial) fluctuations around a mean value activate As consequence, it strongly suggested global antidiabetic...
The present study was designed to define the relative contributions of glucose variability and ambient glycemia incidence asymptomatic hypoglycemia in type 2 diabetes.Two hundred twenty-two persons with diabetes were divided into three groups: Group I (n = 53) on insulin sensitizers alone, II 87) oral hypoglycemic agents (OHAs) include at least one secretagogue, III 82) alone or combination OHAs. Ambient mean concentration (MG) values (in mmol/L) glycemic (SD around value) amplitude...
Microalbuminuria is a reliable predictor of the eventual development overt diabetic nephropathy and blood pressure know to accelerate course this nephropathy. In present studies, effect 6-week treatment by placebo (n=7), nifedipine (n=7) captopril (n=8) on renal function urinary excretion albumin (UAE) was investigated in normotensive, insulin-dependent, patients with incipient (UAE>15 µg/min). No change arterial pressure, or UAE observed group. response nifedipine, mean decreased slightly...
OBJECTIVE To evaluate the respective contributions of short-term glycemic variability and mean daily glucose (MDG) concentration to risk hypoglycemia in type 1 diabetes. RESEARCH DESIGN AND METHODS People with diabetes (n = 100) investigated at University Hospital Montpellier (France) underwent continuous monitoring (CGM) on two consecutive days, providing a total 200 24-h profiles. The following parameters were computed: MDG concentration, within-day (coefficient variation for [%CV]),...