A5013462999- Advancements in Transdermal Drug Delivery
- Transgenic Plants and Applications
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- Lipid Membrane Structure and Behavior
- Innovations in Medical Education
- Interprofessional Education and Collaboration
- Inhalation and Respiratory Drug Delivery
- Pharmaceutical Practices and Patient Outcomes
- Monoclonal and Polyclonal Antibodies Research
- Advanced Drug Delivery Systems
- Advanced Fiber Optic Sensors
- Additive Manufacturing and 3D Printing Technologies
- HIV Research and Treatment
- Education, Achievement, and Giftedness
- Textile materials and evaluations
- T-cell and B-cell Immunology
- Contact Dermatitis and Allergies
- Medical Education and Admissions
- Ocular Surface and Contact Lens
- Optical Coherence Tomography Applications
- Educational Assessment and Pedagogy
- Antibiotic Use and Resistance
Cardiff University
2015-2024
University of Exeter
2018
Microneedle devices are a promising minimally invasive means of delivering drugs/vaccines across or into the skin. However, there is currently diversity microneedle designs and application methods that have, primarily, been intuitively developed by research community. To enable rational design optimised devices, greater understanding human skin biomechanics under small deformations required. This study aims to develop representative stratified model skin, informed in vivo data. A multilayer...
Antigen-specific immunotherapy is an immunomodulatory strategy for autoimmune diseases, such as type 1 diabetes, in which patients are treated with autoantigens to promote immune tolerance, stop β-cell destruction and prevent permanent dependence on exogenous insulin. In this study, human proinsulin peptide C19-A3 (known its positive safety profile) was conjugated ultrasmall gold nanoparticles (GNPs), attractive drug delivery platform due the potential anti-inflammatory properties of gold....
The stratum corneum (SC) represents a significant barrier to the delivery of gene therapy formulations. In order realise potential therapeutic cutaneous transfer, strategies are required overcome this exclusion effect. This study investigates ability microfabricated silicon microneedle arrays create micron-sized channels through SC ex vivo human skin and resulting conduits facilitate localised charged macromolecules plasmid DNA (pDNA). Microscopic studies microneedle-treated epidermal...
Translation of cell therapies to the clinic is accompanied by numerous challenges, including controlled and targeted delivery cells their site action, without compromising viability functionality.To explore use hollow microneedle devices (to date only used for drugs vaccines into skin extraction biological fluids) deliver in a minimally invasive, user-friendly fashion.Melanocyte, keratinocyte mixed epidermal suspensions were passed through various types microneedles subsequently delivered...
Microneedle arrays increase skin permeability by forming channels through the outer physical barrier, without stimulating pain receptors populating underlying dermis. It was postulated that microneedle could facilitate transfer of DNA to human epidermis for cutaneous gene therapy applications. Platinum-coated "wet-etch" silicon microneedles were shown be appropriate dimensions create microconduits, approximately 50 μm in diameter, extending stratum corneum (SC) and viable epidermis....
Antigen specific immunotherapy mediated via the sustained generation of regulatory T cells arguably represents ideal therapeutic approach to preventing beta cell destruction in type 1 diabetes. However, there is a need enhance efficacy this achieve disease modification man. Previous studies suggest that prolonged expression self-antigen skin non-inflammatory context beneficial for tolerance induction. We therefore sought develop dry-coated microneedle (MN) delivery system and combine it with...
Evaluating an undergraduate interprofessional education session for medical and pharmacy undergraduates on therapeutics prescribing: the student perspective Bethany M Shelvey,1 Sion A Coulman,2 Dai N John2 1School of Medicine, 2School Pharmacy Pharmaceutical Sciences, Cardiff University, Cardiff, Wales, UK Background: The current literature (IPE) students highlights a range positive outcomes, although to date IPE has focused predominantly views experiences sessions with these opinions being...
We have investigated the efficacy of conditioning skin Langerhans cells (LCs) with agents to promote tolerance and reduce inflammation, goal improving outcomes antigen-specific immunotherapy. Topical treatments were assessed ex vivo, using excised human breast maintained in organ bath cultures, vivo healthy volunteers by analysing biopsies epidermal blister roof samples. Following topical treatment a corticosteroid, tumour necrosis factor-α levels reduced biopsy studies fluid Blister...