A5061273769- Advancements in Transdermal Drug Delivery
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Dermatology and Skin Diseases
- SARS-CoV-2 and COVID-19 Research
- Toxin Mechanisms and Immunotoxins
- Monoclonal and Polyclonal Antibodies Research
- RNA Interference and Gene Delivery
- Diabetes Management and Research
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Immune Response and Inflammation
- Transgenic Plants and Applications
- Diabetes and associated disorders
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Bacillus and Francisella bacterial research
- Connective tissue disorders research
- Bioactive Compounds and Antitumor Agents
- Viral Infections and Outbreaks Research
- T-cell and B-cell Immunology
- Virology and Viral Diseases
- Obstructive Sleep Apnea Research
- Dental Anxiety and Anesthesia Techniques
- Tracheal and airway disorders
Israel Institute for Biological Research
2014-2021
Tel Aviv University
2000-2001
Barzilai Medical Center
1999-2000
Background. Inactivated polio vaccine (IPV) is necessary for global eradication because oral can rarely cause poliomyelitis as it mutates and may fail to provide adequate immunity in immunocompromised populations. However, IPV unaffordable many developing countries. Intradermal shows promise a means decrease the effective dose cost of IPV, but prior studies, all using 20% standard used intramuscular resulted inferior antibody titers. Methods. We randomly assigned 231 adults with...
In recent years, synthetic mRNA-based applications to produce desired exogenous proteins in cells have been gaining importance. However, systemic delivery of mRNA can result unspecific uptake into undesired or organs and, thereby, fail target cells. Thus, local and targeted becomes increasingly important reach the cell types tissues. this study, intradermal using a hollow microneedle injection-based method was evaluated. Furthermore, an ex vivo porcine skin model established analyze...
Antigen-specific immunotherapy is an immunomodulatory strategy for autoimmune diseases, such as type 1 diabetes, in which patients are treated with autoantigens to promote immune tolerance, stop β-cell destruction and prevent permanent dependence on exogenous insulin. In this study, human proinsulin peptide C19-A3 (known its positive safety profile) was conjugated ultrasmall gold nanoparticles (GNPs), attractive drug delivery platform due the potential anti-inflammatory properties of gold....
Currently available short-acting insulin analogs have slower absorption compared with endogenous occasionally resulting in immediate postprandial hyperglycemia. Intradermal (ID) injection facilitates faster drug and may result improved pharmacokinetics.Seventeen patients type 2 diabetes were included this single-center, pilot, open-label crossover study. Patients received 0.2 U/kg Insulin aspart ID injections using a MicronJet (MJ) needle subcutaneous (SC) injections, conventional design....
Influenza remains a significant problem in elderly despite widespread vaccination coverage. This randomized, phase-I study compared different strategies of improving vaccine immunogenicity.A total 370 healthy participants (⩾65years) were randomized equally 1:1:1:1:1:1 to six influenza treatments (approximately 60-63 per treatment arm) at day 1 that consisted three investigational virosomal formulations doses 7.5, 15, and 45μg HA antigen/strain administered intradermally (ID) by MicronJet600™...
Elastin is one of the most important and abundant extracellular matrix (ECM) proteins that provide elasticity resilience to tissues organs, including vascular walls, ligaments, skin, lung. Besides hereditary diseases, such as Williams-Beuren syndrome (WBS), which results in reduced elastin synthesis, injuries, aging, or acquired diseases can lead degradation existing fibers. Thus, de novo synthesis required several medical conditions restore affected tissues. Here, we applied synthetic...
We present an adjuvant for intradermal use that works in humans, enabling self-administration case of a flu pandemic.
Intradermal delivery of self-replicating RNA (srRNA) is a promising vaccine platform. We have developed an srRNA that functions optimally at around 33°C (skin temperature) and inactivated or above 37°C (core body as safety switch. This temperature-controllable (c-srRNA), when tested intradermal against SARS-CoV-2, injected naked without lipid nanoparticles. Unlike most currently available vaccines, c-srRNA vaccines predominantly elicit cellular immunity with little no antibody production....
Strategies to optimize responses seasonal influenza vaccination in older adults include the use of adjuvants, higher antigen doses, and intradermal delivery. In this study aged ≥65 years (n = 450) received a single dose 1 2 non-adjuvanted trivalent vaccine (TIV) formulations administered intradermally (ID), both containing 6 µg A/H1N1 B, differing A/H3N2 content (6 or 12 µg), 8 TIV intramuscularly (IM) all 15 hemagglutinin (HA) (15 30 µg) and/or MF59® adjuvant (0%, 25%, 50%, 100% standard...
Live-attenuated oral rotavirus (RV) vaccines have lower efficacy in low income countries, and additionally are associated with a rare but severe adverse event, intussusception. We been pursuing the development of an inactivated vaccine (IRV) using human strain CDC-9 (G1P[8]) through parenteral immunization previously demonstrated dose sparing enhanced immunogenicity intradermal (ID) unadjuvanted IRV coated microneedle patch comparison intramuscular (IM) administration mice. The aim this...
Patients on dialysis are hyporesponsive to the hepatitis B virus vaccines (HBVv). We examined intradermal (ID) HBVv Sci-B-Vac, with topical Toll-like receptor 7 (TLR7) agonist imiquimod pretreatment in patients.We enrolled and prospectively followed adult patients between January 2016 September 2018. Eligible were randomly allocated (1:1:1) into 1 treatment group, cream by ID (IMQ + ID); 2 control groups: aqueous (placebo) (AQ ID) or intramuscular IM). The primary endpoint was seroprotection...
Assessment of immune responses in lymph nodes (LNs) is routine animals, but rarely done humans. We have applied minimally invasive ultrasound-guided fine-needle aspiration the LN to a before-and-after study response intradermally delivered Ag healthy volunteers (n = 25). By comparison with PBMCs from same individual, cells (LNCs) were characterized by reduced numbers effector memory cells, especially CD8(+) TEMRA (3.37 ± 1.93 LNCs versus 22.53 7.65 PBMCs; p 0.01) and marked increased CD69...
Background Peripheral venous cannulation is one of the most common procedures in medicine. It associated with noticeable pain and apprehension, although cases it performed without any anesthesia due to lack a painless, cost-effective option, which would provide rapid local subsequent significant reduction experienced pain. We conducted an open-label placebo-controlled clinical trial evaluate efficacy safety 2% lidocaine injection using commercially available microneedle device MinronJet600...
Intradermal delivery of vaccines has been shown to result in dose sparing. We tested the ability fractional doses inactivated poliovirus vaccine (IPV) delivered intradermally induce levels serum poliovirus-neutralizing antibodies similar immunization through intramuscular route. Immunogenicity IPV was studied by comparing and intradermal Wistar rats using NanoPass MicronJet600 microneedles. partial induced at titers comparable those after with full human intramuscularly. The results suggest...