A5000970718- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Hepatitis Viruses Studies and Epidemiology
- Respiratory viral infections research
- Virus-based gene therapy research
- Congenital Anomalies and Fetal Surgery
- Child Nutrition and Water Access
- Clostridium difficile and Clostridium perfringens research
- Viral Infectious Diseases and Gene Expression in Insects
- Vector-Borne Animal Diseases
- Gastrointestinal disorders and treatments
- Infant Nutrition and Health
- Advanced Thermodynamic Systems and Engines
- Transgenic Plants and Applications
- SARS-CoV-2 and COVID-19 Research
- Pediatric Hepatobiliary Diseases and Treatments
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- Gut microbiota and health
- Toxin Mechanisms and Immunotoxins
- Herpesvirus Infections and Treatments
- Salmonella and Campylobacter epidemiology
Capital Institute of Pediatrics
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Centers for Disease Control and Prevention
2015-2024
National Center for Immunization and Respiratory Diseases
2014-2024
Government of the United States of America
2018-2021
AID Atlanta
2011-2015
Global Viral
2006-2015
University of North Carolina at Chapel Hill
2014
National Autonomous University of Nicaragua
2014
Universidad Nacional Autónoma de Nicaragua-León
2014
Antigen-based tests for SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), are inexpensive and can return results within 15 minutes (1). Antigen have received Food Drug Administration (FDA) Emergency Use Authorization (EUA) use in asymptomatic symptomatic persons first 5-12 days after symptom onset (2). These been used at U.S. colleges universities other congregate settings (e.g., nursing homes correctional detention facilities), where serial testing of might facilitate...
The genomic RNA of human astrovirus was sequenced and found to contain 6797 nt organized into three open reading frames (1a, 1b, 2). A potential ribosomal frameshift site identified in the overlap region 1a 1b consists a "shifty" heptanucleotide an stem-loop structure that closely resemble those at gag-pro junction some retroviruses. This translation frame-shift may result suppression in-frame amber termination end frame synthesis nonstructural, fusion polyprotein contains putative protease...
Rabies virus (RV) induces encephalomyelitis in humans and animals. However, the pathogenic mechanism of rabies is not fully understood. To investigate host responses to RV infection, we examined compared pathology, particularly inflammatory responses, gene expression profiles brains mice infected with wild-type (wt) silver-haired bat (SHBRV) or laboratory-adapted B2C, using a mouse genomic array (Affymetrix). Extensive were observed animals attenuated RV, but little no found wt RV....
We report the sequence of subgenomic RNA human astrovirus serotype 2. This 2,484-nucleotide contains a single open reading frame, which encodes protein with predicted molecular mass 88 kDa. propose that this is 90-kDa capsid precursor observed in infected cells. The deduced does not contain conserved amino acid patterns reported for proteins picornaviruses or caliciviruses, consistent classification astroviruses as new family viruses, designated Astroviridae.
Abstract Over the past several years, acute and fatal respiratory illnesses have occurred in habituated group of wild chimpanzees at Mahale Mountains National Park, Tanzania. Common viruses, such as measles influenza, been considered possible causative agents; however, neither these viruses had detected. During 2003, 2005 2006, regular observations on affected individuals were recorded. Cause‐specific morbidity rates 98.3, 52.4 33.8%, respectively. Mortality 6.9, 3.2 4.6%; all deaths...
The distal portion of rotavirus (RV) VP4 spike protein (VP8*) is implicated in binding to cellular receptors, thereby facilitating viral attachment and entry. While VP8* some animal RVs engage sialic acid, human often attach enter cells a acid-independent manner. A recent study demonstrated that the major (P[4], P[6], P[8]) recognize histo-blood group antigens (HBGAs). In this study, we performed phylogenetic analysis showed further variations RV interaction with HBGAs. On basis sequences,...
Live oral rotavirus vaccines have been less immunogenic and efficacious among children in poor developing countries compared with middle income industrialized for reasons that are not yet completely understood. We assessed whether the neutralizing activity of breast milk could lower titer vaccine virus explain this difference vitro.Breast samples were collected from mothers who breast-feeding infants 4 to 29 weeks age (ie, eligible age) India (N = 40), Vietnam 77), South Korea 34), United...
Rotavirus vaccines (RVV) protect against childhood gastroenteritis caused by rotavirus (RV) but have decreased effectiveness in low- and middle-income settings. This proof-of-concept, randomized-controlled, open-label trial tested if microbiome modulation can improve RVV immunogenicity. Healthy adults were randomized administered broad-spectrum (oral vancomycin, ciprofloxacin, metronidazole), narrow-spectrum (vancomycin), or no antibiotics then vaccinated with RVV, 21 per group protocol....
Individual human VP4- and VP7-binding monoclonal antibodies mediate serotype cross-reactive neutralizing immunity to rotaviruses.
ABSTRACT Rotavirus is the most common cause of severe gastroenteritis in young children, but pathogenesis and immunity this disease are not completely understood. To examine host response to acute infection, we collected paired serum specimens from 30 children with rotavirus diarrhea measured levels nine cytokines (interleukin-1β [IL-1β], IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, gamma interferon [IFN-γ], tumor necrosis factor alpha [TNF-α]) using a microsphere-based Luminex Flowmetrix system....
To investigate the effect of abstention from breastfeeding, for an hour before and after each vaccination, on immune responses infants to two doses rotavirus vaccine.In Soweto, South Africa, mother-infant pairs who were uninfected with human immunodeficiency virus (HIV) enrolled as they presented "6-week" immunizations infants. Each infant was randomly assigned Group 1 - in which breastfeeding deferred at least h dose vaccine or 2 unrestricted encouraged. Enzyme-linked immunosorbent assays...