A5100355634- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Viral gastroenteritis research and epidemiology
- Head and Neck Cancer Studies
- RNA Interference and Gene Delivery
- Effects of Radiation Exposure
- DNA Repair Mechanisms
- Viral Infections and Immunology Research
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Per- and polyfluoroalkyl substances research
- Animal Virus Infections Studies
- RNA and protein synthesis mechanisms
- Salivary Gland Tumors Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Head and Neck Surgical Oncology
- Telomeres, Telomerase, and Senescence
- Metabolomics and Mass Spectrometry Studies
- Cancer Immunotherapy and Biomarkers
- Berberine and alkaloids research
- Sirtuins and Resveratrol in Medicine
- Escherichia coli research studies
- Gut microbiota and health
- Ear and Head Tumors
- Genomics, phytochemicals, and oxidative stress
Third Hospital of Nanchang
2025
Veracyte (United States)
2022-2025
China Agricultural University
2025
China Pharmaceutical University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
Guang’anmen Hospital
2024
Mayo Clinic in Florida
2024
Affiliated Hospital of Taishan Medical University
2024
Shandong First Medical University
2024
Guangdong Ocean University
2011-2024
Programmed cell death-1 (PD-1)/programmed death ligand-1 (PD-L1) blocking therapy has become a major pillar of cancer immunotherapy. Compared with antibodies targeting, small-molecule checkpoint inhibitors which have favorable pharmacokinetics are urgently needed. Here we identified berberine (BBR), proven anti-inflammation drug, as negative regulator PD-L1 from set traditional Chinese medicine (TCM) chemical monomers. BBR enhanced the sensitivity tumour cells to co-cultured T-cells by...
The distal portion of rotavirus (RV) VP4 spike protein (VP8*) is implicated in binding to cellular receptors, thereby facilitating viral attachment and entry. While VP8* some animal RVs engage sialic acid, human often attach enter cells a acid-independent manner. A recent study demonstrated that the major (P[4], P[6], P[8]) recognize histo-blood group antigens (HBGAs). In this study, we performed phylogenetic analysis showed further variations RV interaction with HBGAs. On basis sequences,...
Abstract Hepatocellular carcinoma (HCC) is the third leading cause of cancer‐related death worldwide. The prognosis HCC remains very poor; thus, an effective treatment urgent. Herein, a type nanomedicine developed by conjugating Fe@Fe 3 O 4 nanoparticles with ginsenoside Rg3 (NpRg3), which achieves excellent coupling effect. In dimethylnitrosamine‐induced model, NpRg3 application significantly prolongs survival mice. Further research indicates that inhibits development and eliminates...
Abstract The acquisition of radioresistance by breast cancer cells during radiotherapy may lead to recurrence and poor survival. Signal transducer activator transcription 3 (Stat3) is activated in and, therefore, be an effective target for overcoming therapeutic resistance. Mesenchymal stem (MSCs) have been investigated use treatment. Here, we the potential MSC conditioned medium (MSC-CM) sensitizing radiotherapy. It was found that MSC-CM could inhibit level Stat3, suppress growth, exhibit...
<h3>Importance</h3> Hashimoto thyroiditis (HT) has been suggested to be associated with papillary thyroid cancer (PTC) development. However, its association PTC progression remains unclear. <h3>Objective</h3> To examine the between HT and presentation outcomes. <h3>Design, Setting, Participants</h3> This retrospective cohort study included a review of patients aged 18 75 years who had pathologically confirmed treated at single center in China from January 1, 2001, December 31, 2014. Data...
Human CST (CTC1-STN1-TEN1) is an RPA-like complex that associates with G-rich single-strand DNA and helps resolve replication problems both at telomeres genome-wide. We previously showed binds disrupts G-quadruplex (G4) in vitro, suggesting may prevent vivo blocks to by resolving G4 structures. Here, we demonstrate unfolds similar efficiency RPA. In cells, recruited telomeric non-telomeric chromatin upon stabilization, even when ATR/ATM pathways were inhibited. STN1 depletion increases...
Berberine (BBR), a traditional Chinese medicine, has therapeutic effects on variety of inflammation-related diseases, but its direct proteomic targets remain unknown. Using activity-based protein profiling, we first demonstrated that BBR directly the NEK7 via hydrogen bond between 2,3-methylenedioxy and 121-arginine (R121) residues. The fact R121 is located precisely within key domain involved in NEK7–NLRP3 interaction allows to specifically block successively inhibit IL-1β release,...
Nuclear factor erythroid 2-related 2 (NRF2) is a well-characterized transcription that protects cells against oxidative and electrophilic stresses. Emerging evidence has suggested NRF2 DNA damage by mechanisms other than antioxidation, yet the mechanism remains poorly understood. Here, we demonstrate knockout of in results hypersensitivity to ionizing radiation (IR) presence or absence reactive oxygen species (ROS). Under ROS scavenging conditions, induction double-strand breaks (DSBs)...
In the frame of radiotherapy treatment cancer, radioresistance remains a major issue that still needs solutions to be overcome. To effectively improve radiosensitivity tumors and reduce damage radiation neighboring normal tissues, radiosensitizers have been given increasing attention in recent years. As nanoparticles based on metal element gadolinium, AGuIX shown increase cancers. Although it is rare nanomaterial has entered preclinical trials, unclear biological mechanism hinders its...
Abstract Insufficient bone formation and excessive resorption caused by estrogen deficiency are the major factors resulting in incidence of postmenopausal osteoporosis (PMOP). The existing drugs usually fail to re‐establish osteoblast/osteoclast balance from both sides generate side‐effects owing lack bone‐targeting ability. Here, engineered cell‐membrane‐coated nanogels PNG@mR&C capable scavenging receptor activator nuclear factor‐κB ligand (RANKL) responsively releasing therapeutic PTH...
The effects of performing video display terminal (VDT) tasks with a bright (BD) at night on nocturnal salivary melatonin concentration, rectal temperature, heart rate, and sleepiness were examined. Seven healthy male adults performed exciting VDT BD dark (DD) boring DD from 2300 to 0200. light intensities the 45 15 lx each subject's eye level, respectively. task both significantly suppressed decrease in temperature rate increase sleepiness. during tasks. concentration was by combination BD....
To determine the role of leptin in modulating Th17 cell response and joint inflammation mice with collagen-induced arthritis (CIA).Leptin receptor expression on T cells was examined by polymerase chain reaction (PCR) analysis, immunofluorescence microscopy, flow cytometry. Effects differentiation proliferation were evaluated quantitative PCR, carboxyfluorescein diacetate succinimidyl ester assay, Dynamic changes concentrations tissue synovial fluid CIA determined immunohistochemistry...
Nine new grayanoids (1–9), together with 11 known compounds, were isolated from the roots of Rhododendron molle. The structures compounds (1–9) determined on basis spectroscopic analysis, including HRESIMS, and 1D 2D NMR data. Compounds 4, 6, 12, 14–20 showed significant antinociceptive activities in an acetic acid-induced writhing test. In particular, 14 15 found to be more potent than morphine for both acute inflammatory pain models 100-fold gabapentin a diabetic neuropathic model.
Abstract Title. 'Making the best of it': Chinese women's experiences adjusting to breast cancer diagnosis and treatment. Aim. This paper is a report study describe women’s Background. Breast most common in women, its treatment are pivotal life‐changing events that prompt women make immediate adjustments. Adjustment has been studied as way coping with stressful event adapting chronic illness. Adequate adjustment through adaptation leads successful completion improved quality life. Method. A...
Small molecule complexes with DNA that incorporate linking water molecules are rare, and the DB921-DNA complex has provided a unique well-defined system for analysis of water-mediated binding in context complex. DB921 benzimidazole-biphenyl terminal amidines results linear conformation does not possess appropriate radius curvature to match minor groove shape represents new paradigm fit classical model interactions. To better understand role bound observed X-ray crystal structure complex,...
Rotavirus (RV) P[11] is an unique genotype that infects neonates. The mechanism of such age-specific host restriction remains unknown. In this study, we explored mucosal glycans as a potential factor for attachment RVs. Using in vitro binding assays, demonstrated VP8* RV (N155) could bind saliva infants (60.3%, N = 151) but not adults (0%, 48), with significantly negative correlation between and ages (P<0.01). Recognition to the infant did correlate ABO, secretor Lewis histo-blood group...
The P[19] genotype belongs to the P[II] genogroup of group A rotaviruses (RVs). However, unlike other RVs, which mainly infect humans, RVs commonly animals (pigs), making unique for study RV diversity and host ranges. Through in vitro binding assays saturation transfer difference (STD) nuclear magnetic resonance (NMR), we found that could bind mucin cores 2, 4, 6, as well type 1 histo-blood antigens (HBGAs). common sequences these glycans serve minimal units, while additional residues, such...
Environmentally persistent organic pollutant (POP) is the general term for refractory compounds that show long-range atmospheric transport, environmental persistence, and bioaccumulation. It has been reported accumulation of POPs could lead to cellular DNA damage adverse effects on metabolic health. To better understand mechanism health risks associated with POPs, we conducted an evidence-based cohort investigation (n = 5,955) at Jinghai e-waste disposal center in China from 2009 2016, where...
Radiotherapy is the main treatment for cancer patients. A major concern in radiotherapy radiation resistance of some tumors, such as human nonsmall cell lung cancer. However, dose delivered to tumors often limited by possibility collateral damage surrounding healthy tissues. new and efficient gadolinium-based nanoparticle, AGuIX, has recently been developed magnetic resonance imaging-guided proven act an radiosensitizer. The amplified effects AGuIX nanoparticles appear be due emission...