A5068066029- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Bioactive Natural Diterpenoids Research
- Microbial Natural Products and Biosynthesis
- Magnolia and Illicium research
- Traditional and Medicinal Uses of Annonaceae
- Plant-derived Lignans Synthesis and Bioactivity
- Fungal Biology and Applications
- Crystallography and molecular interactions
- Marine Sponges and Natural Products
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Bioactive Compounds
- Plant-based Medicinal Research
- Phytochemical compounds biological activities
- Plant Toxicity and Pharmacological Properties
- Plant biochemistry and biosynthesis
- Phytochemicals and Antioxidant Activities
- Sesquiterpenes and Asteraceae Studies
- Bioactive Compounds and Antitumor Agents
- Chemical synthesis and alkaloids
- Phytochemical Studies and Bioactivities
- Biological Activity of Diterpenoids and Biflavonoids
- Plant and fungal interactions
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
State Council of the People's Republic of China
2021
Xinjiang Institute of Materia Medica
2017-2021
Peking Union Medical College Hospital
2007-2021
Huazhong Agricultural University
2018-2019
Academy of Medical Sciences
2017-2018
Michigan State University
2009-2015
University of California, Los Angeles
2013
King Saud University
2011
PhytoCeutica (United States)
2009-2010
Objective: To report a prospective multicenter comparison of outcomes patients who attempted trial labor and those underwent elective repeat cesarean. Methods: During the study interval, all pregnant women with previous cesarean delivery cared for at Kaiser Permanente Hospitals in Southern California were studied regardless whether or was planned. Results: Of 7229 patients, 5022 (70%) had 2207 operations. Seventy-five percent (3746) opting went on to deliver vaginally. The rate uterine...
Although many studies describe benefits from the comprehensive assessment of elderly patients by an interdisciplinary team (comprehensive geriatric assessment), most supportive evidence for process has come programs that rely on specialized inpatient units and long hospital stays. We examined whether consultation service might also be beneficial in a trial involving four medical centers group-practice health maintenance organization (HMO).We conducted randomized clinical with 2353...
Antioxidants scavenge free radicals, singlet oxygen, and electrons in cellular redox reactions. The yellow MTT [3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide] is reduced to a purple formazan by mitochondrial enzymes. NADPH the basis of established vitro cell viability assays. An antioxidant assay has been developed utilizing reaction between selected natural product extracts purified compounds. This simple, fast, inexpensive comparable with lipid peroxidation inhibitory can...
Three new trace bisindole alkaloids geleganimines A and B (1, 2) geleganamide (3) were isolated from the aerial parts of Gelsemium elegans. Their structures elucidated by spectroscopy, particularly their carbon–proton coupling constants, electronic circular dichroism. Compounds 1–3 are first discovered genus Gelsemium. Geleganimine exhibited anti-inflammatory activity indirectly suppressing lipopolysaccharide-induced pro-inflammatory factors in BV2 microglial cells with an IC50 value 10.2...
Nine new grayanoids (1–9), together with 11 known compounds, were isolated from the roots of Rhododendron molle. The structures compounds (1–9) determined on basis spectroscopic analysis, including HRESIMS, and 1D 2D NMR data. Compounds 4, 6, 12, 14–20 showed significant antinociceptive activities in an acetic acid-induced writhing test. In particular, 14 15 found to be more potent than morphine for both acute inflammatory pain models 100-fold gabapentin a diabetic neuropathic model.
Four new sesquiterpenes (1–4), four alkaloids (5a, 6a, 6b, and 7), nine known compounds (5b 8–15) were isolated from an ethanolic extract of roots Alangium chinense. The structure 1 was confirmed by X-ray crystallography. configurations 5 6 assigned chiral HPLC analysis CD spectra. Compounds 3, 4, 8–13, 15 exhibited antiviral activity against Coxsackie virus B3 with IC50 values 1.4–15.4 μM. 2–4, 7, 9–13 showed antioxidant activities Fe2+-cysteine-induced rat liver microsomal lipid...
Illisimonin A, an unprecedented sesquiterpenoid with a tricyclo[5.2.1.01,6]decane skeleton, was isolated from the fruits of Illicium simonsii. The structure and absolute configuration 1 were determined using extensive spectroscopic evidence electronic circular dichroism (ECD) calculations. It that possesses caged 2-oxatricyclo[3,3,0,14,7]nonane ring system fused to five-membered carbocyclic lactone ring. A plausible biogenetic pathway for proposed, showed neuroprotective effects against...
Sesquiterpene synthases (STPSs) catalyze carbocation-driven cyclization reactions that can generate structurally diverse hydrocarbons. The deprotonation-reprotonation process is widely used in STPSs to promote structural diversity, largely attributable the distinct regio/stereoselective reprotonations. However, molecular basis for reprotonation regioselectivity remains understudied. Herein, we analyzed two highly paralogous STPSs, Artabotrys hexapetalus (-)-cyperene synthase (AhCS) and...
Black pepper (Piper nigrum) and hot (Capsicum spp.) are widely used in traditional medicines. Although Capsicum spp. extracts its active principles, capsaicinoids, have been linked with anticancer anti-inflammatory activities, whether black principle exhibit similar activities is not known. In this study, we evaluated the antioxidant, of compounds from by using proinflammatory transcription factor NF-kappaB, COX-1 -2 enzymes, human tumor cell proliferation lipid peroxidation (LPO). The...
Hot peppers are known for medicinally important capsaicinoids. Bhut Jolokia, Capsicum chinense/Capsicum frutescens, is the hottest pepper in world. However, its bioactivity and quantity of heat principles not reported. We have now quantified capsaicin (C) dihydrocapsaicin (DHC) Jolokia compared it with commonly consumed hot peppers, Jalapeno (Capsicum annuum) Scotch Bonnet chinense). The concentration C DHC was 5.36%, which about 338 18 times greater than Jalapeno, respectively. also...
Three new rearranged prenylated C6−C3 compounds, named illioliganones A, B, and C (1−3), a highly oxygenated seco-prezizaane-type sesquiterpene, oligandriortholactone (7), together with three known compounds (4−6) sesquiterpene lactone (8), have been isolated from the stem bark of Illicium oligandrum. The structures 1−3 7 were elucidated by spectroscopic methods including 1D 2D NMR, HRMS, CD experiments. absolute configuration 11,12-diol moiety in 2 3 was determined on basis observing...
The arid plant Prosopis cineraria (Fabaceae) is known as Khejri in India or the golden tree of Indian deserts. dried pods are consumed a vegetable and leaves traditional medicine to cure wide range diseases state Rajasthan, India. this have not been investigated for their bioactive components, hence we done so study. were boiled with water afford aqueous extract. Extraction residue gave methanolic lipid peroxidation (LPO) cyclooxygenase enzymes (COX-1 -2) inhibitory activities extracts major...
Two novel spirooliganones A (1) and (2), a pair of spiro carbon epimers, with rare dioxaspiro skeleton were isolated from the roots Illicium oligandrum. The structures fully determined by spectroscopic analysis chemical methods, especially modified Mosher's method, X-ray diffraction analysis. Spirooliganone B was found to exhibit more potent activities against coxsackie virus B3 influenza (H3N2) (IC50 3.70–5.05 μM) than spirooliganone A. biosynthetic pathway involving hetero-Diels–Alder...
Two new grayanoids, mollanol A (1) and rhodomollein XXV (2), were isolated from the fruits of Rhododendron molle. Their structures elucidated by spectroscopic methods X-ray diffraction analyses. Mollanol possesses a C-nor-D-homograyanane carbon skeleton, while (2) is first example an 11,16-epoxygrayanane features caged oxa-tricyclo[3.3.1.03.7]nonane ring system. Plausible biogenetic pathways for 1 proposed. Compound exhibited transcriptional activation effects on xbp1 upstream promoter in...
Eight new cadinene-sesquiterpenes (1-8), one eudesmane-sesquiterpene (9), and three known compounds (10-13) were isolated from an endophytic fungus, Aspergillus flavus, which was a toxic medicinal plant, Tylophora ovata. Their structures elucidated by interpretation of spectroscopic data, absolute configurations determined according to the specific rotation electron circular dichroism methods. Compounds 4-8, 11, 12 exhibited latent hepatic protection effects at 10 μM, compound selectively...
Two new alkaloids, lycojaponicumins D (1) and E (2), were isolated from the club moss Lycopodium japonicum. Their structures elucidated by spectroscopic methods, calculated ECD, CD experiments X-ray diffraction analysis. Lycojaponicumin possesses an unprecedented 5/7/6/6 tetracyclic skeleton formed unusual C3–C13 linkage, which is first reported in alkaloids. The plausible biogenetic pathway of 1 proposed.