A5100355457- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Bioactive Natural Diterpenoids Research
- Magnolia and Illicium research
- Traditional and Medicinal Uses of Annonaceae
- Marine Sponges and Natural Products
- Plant-based Medicinal Research
- Microbial Natural Products and Biosynthesis
- Biological Activity of Diterpenoids and Biflavonoids
- Plant-derived Lignans Synthesis and Bioactivity
- Sesquiterpenes and Asteraceae Studies
- Phytochemical compounds biological activities
- Plant Toxicity and Pharmacological Properties
- Chemical synthesis and alkaloids
- Plant biochemistry and biosynthesis
- Alkaloids: synthesis and pharmacology
- Phytochemistry and Bioactive Compounds
- Fungal Biology and Applications
- Bioactive Compounds and Antitumor Agents
- Essential Oils and Antimicrobial Activity
- Oxidative Organic Chemistry Reactions
- Synthetic Organic Chemistry Methods
- Plant Pathogenic Bacteria Studies
- Berberine and alkaloids research
- Pharmacological Effects of Natural Compounds
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2010-2025
Shanghai Institute of Materia Medica
2025
Research Center for Eco-Environmental Sciences
2024
Chinese Academy of Sciences
2018-2024
University of Chinese Academy of Sciences
2024
Shandong Normal University
2018-2024
University of Nebraska–Lincoln
2022-2023
Capital University
2022-2023
Capital Medical University
2022-2023
Abstract Organic room‐temperature phosphorescence (RTP) materials are actively explored as attractive candidates for optoelectronic and bioelectronics applications given their unique long‐lived excited‐state features inherent merits of low‐cost, appreciable functionality, good biocompatibility. In recent years, many efforts in molecular design aggregation modulation devoted to achiev efficient RTP from organics, among which an emerging strategy focuses on confining chromophores within...
Seven new indole alkaloids, bruceollines H–N (1–7), three quassinoids, yadanziolides T–V (10–12), and four known analogues, bruceolline E (8), F (9), bruceine D (13), yadanziolide B (14), were isolated from an ethanol extract of the stems Brucea mollis. The absolute configurations compounds 2 5 determined by comparison their experimental calculated ECD spectra. configuration compound 9 was using Mo2(OAc)4-induced CD analysis for first time. Compounds 10, 13, 14 exhibited cytotoxic activities...
Chemical examination of the solid culture endophytic fungus Stachybotrys chartarum isolated from sponge Niphates recondita resulted in isolation 16 new phenylspirodrimanes, named chartarlactams A–P (1–16), together with eight known analogues. Their structures were determined on basis extensive spectroscopic analysis, including X-ray single-crystal diffraction for determination absolute configurations. The isoindolone-drimane dimer chartarlactam L (12) was as a skeleton. Compounds 1–6 and...
Nine new grayanoids (1–9), together with 11 known compounds, were isolated from the roots of Rhododendron molle. The structures compounds (1–9) determined on basis spectroscopic analysis, including HRESIMS, and 1D 2D NMR data. Compounds 4, 6, 12, 14–20 showed significant antinociceptive activities in an acetic acid-induced writhing test. In particular, 14 15 found to be more potent than morphine for both acute inflammatory pain models 100-fold gabapentin a diabetic neuropathic model.
Neuropathic pain is a chronic disease that severely afflicts the life and emotional status of patients, but currently available treatments are often ineffective. Novel therapeutic targets for alleviation neuropathic urgently needed. Rhodojaponin VI, grayanotoxin from Rhododendron molle, showed remarkable antinociceptive efficacy in models pain, its biotargets mechanisms unknown. Given reversible action rhodojaponin VI narrow range over which structure can be modified, we perforwmed thermal...
Illisimonin A, an unprecedented sesquiterpenoid with a tricyclo[5.2.1.01,6]decane skeleton, was isolated from the fruits of Illicium simonsii. The structure and absolute configuration 1 were determined using extensive spectroscopic evidence electronic circular dichroism (ECD) calculations. It that possesses caged 2-oxatricyclo[3,3,0,14,7]nonane ring system fused to five-membered carbocyclic lactone ring. A plausible biogenetic pathway for proposed, showed neuroprotective effects against...
In this study, two alginate-based hydrogels with good mechanical strength, toughness and resilience were synthesized by hydrophobic interaction coordination bonding. Sodium alginate/poly(acrylamide) semi-interpenetrating network (NaAlg/PAM semi-IPN) first through the micelle copolymerization of acrylamide stearyl methacrylate in presence sodium alginate, then calcium double (CaAlg/PAM DN) prepared immersing as-prepared NaAlg/PAM semi-IPN a CaCl2 solution. FT-IR XPS results revealed CaAlg/PAM...
A new anthracene glycoside, asperflavin ribofuranoside (1), and the previously described polyketides, flavoglaucin (2), isodihydroauroglaucin (3), citrinin (4) have been isolated from marine-derived fungus Microsporum sp. The structure absolute stereochemistry of a compound (1) was assigned on basis physicochemical data. Compounds 1—3 exhibited significant radical scavenging activity against 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 values 14.2, 11.3, 11.5 μM, respectively, which are...
Two novel spirooliganones A (1) and (2), a pair of spiro carbon epimers, with rare dioxaspiro skeleton were isolated from the roots Illicium oligandrum. The structures fully determined by spectroscopic analysis chemical methods, especially modified Mosher's method, X-ray diffraction analysis. Spirooliganone B was found to exhibit more potent activities against coxsackie virus B3 influenza (H3N2) (IC50 3.70–5.05 μM) than spirooliganone A. biosynthetic pathway involving hetero-Diels–Alder...
Two new grayanoids, mollanol A (1) and rhodomollein XXV (2), were isolated from the fruits of Rhododendron molle. Their structures elucidated by spectroscopic methods X-ray diffraction analyses. Mollanol possesses a C-nor-D-homograyanane carbon skeleton, while (2) is first example an 11,16-epoxygrayanane features caged oxa-tricyclo[3.3.1.03.7]nonane ring system. Plausible biogenetic pathways for 1 proposed. Compound exhibited transcriptional activation effects on xbp1 upstream promoter in...
Eight new cadinene-sesquiterpenes (1-8), one eudesmane-sesquiterpene (9), and three known compounds (10-13) were isolated from an endophytic fungus, Aspergillus flavus, which was a toxic medicinal plant, Tylophora ovata. Their structures elucidated by interpretation of spectroscopic data, absolute configurations determined according to the specific rotation electron circular dichroism methods. Compounds 4-8, 11, 12 exhibited latent hepatic protection effects at 10 μM, compound selectively...
Abstract Objective This study used deep learning for diagnosing common, benign hyperpigmentation. Method In this study, two convolutional neural networks were to identify six pigmentary diseases, and a disease diagnosis model was established. Because the distribution of lesions in original training picture is very complex, we cropped image around lesions, trained network on extracted lesion images, fused verification results overall assess performance identifying hyperpigmented dermatitis...
Ten new grayanane-derived diterpenoids, rhodomollein LVII-LXVI (1-10), along with the known compound XLIII (11), were isolated from flowers of Rhododendron molle. Their structures elucidated by detailed spectroscopic analysis, X-ray diffraction crystallography, and ECD calculations. Rhodomollein LVII-LIX (1-3) are first-discovered 3-O-(E)-p-coumaroylquinic acid, nicotinic 2-furoic acid derivatives grayanane respectively. In an acetic acid-induced writhing test, compounds 1 3 demonstrated...
The dictyostelids (also called cellular slime molds or social amoebae) are among the more abundant and widespread groups of microorganisms in terrestrial ecosystems. Despite this fact, they totally unknown to most people, who sometimes confuse with myxomycetes (or plasmodial molds). first dictyostelid (Dictyostelium mucoroides) was described by German Oskar Brefeld 1869. More than 180 species now known, these organisms have been recorded from high arctic subantarctic. primary microhabitat...
DNA methylation regulators play critical roles in modulating oncogenic driver genes cancers. However, the precise mechanisms through which these influence oncogenesis and clinical therapy have yet to be fully elucidated. This study reveals that hypermethylation of under-methylated regions (UMRs) within gene bodies is involved activation homeobox genes, particularly NKX2-5 LHX1, esophageal squamous cell carcinoma (ESCC). Mechanistically, LHX1 synergistically bind promoter region UHRF1,...
As a valuable medicinal plant, the yield of Panax ginseng is seriously affected by autotoxicity, which common phenomenon due to continuous cropping. However, mechanism autotoxicity in P. still unknown. In total, high throughput sequencing 18 RNA-Seq libraries produced 996,000 000 100-nt reads that were assembled into 72,732 contigs. Compared with control, 3697 and 2828 genes significantly up- down-regulated across different tissues time points, respectively. Gene Ontology enrichment analysis...
Mollolide A (1), a diterpenoid featuring new 1,10:2,3-disecograyanane skeleton, was isolated from the roots of Rhododendron molle. Its structure elucidated through extensive MS, IR, and NMR spectroscopy analyses. The absolute configuration determined by single-crystal X-ray diffraction its p-bromobenzoate derivative (1b). Compound 1 exhibits significant analgesic effect at dose 20 mg/kg antiviral activity against Coxsackie B3 virus with an IC50 value 27.7 μM.
Seven new sesquiterpenes (1, 3–8), a sesquiterpene natural product (2), and two lignans (9 10), together with 15 known compounds, were isolated from the fruits of Xanthium sibiricum. The structures compounds established by NMR spectroscopic analysis, ECD calculations, Mo2(OAc)4-induced circular dichroism, 1 4 confirmed single-crystal X-ray diffraction. Compound is first example 3/5/6/5 tetracyclic eudesmane lactone formed at C-6 C-7. In turn, compound xanthane tetranorsesquiterpene, while...