A5081392604- Natural product bioactivities and synthesis
- Electrocatalysts for Energy Conversion
- Computational Drug Discovery Methods
- HIV/AIDS drug development and treatment
- Advanced Memory and Neural Computing
- Magnolia and Illicium research
- Phytochemical compounds biological activities
- Ginseng Biological Effects and Applications
- Estrogen and related hormone effects
- Traditional Chinese Medicine Analysis
- Retinoids in leukemia and cellular processes
- Phytochemistry and Bioactive Compounds
- ATP Synthase and ATPases Research
- Natural Compounds in Disease Treatment
- Hepatitis C virus research
- Pharmacological Effects of Natural Compounds
- Signaling Pathways in Disease
- Phytochemical Studies and Bioactivities
- Autophagy in Disease and Therapy
- Histone Deacetylase Inhibitors Research
- Medicinal Plant Pharmacodynamics Research
- Protein Structure and Dynamics
- Nanomaterials for catalytic reactions
- Mosquito-borne diseases and control
- Immune Response and Inflammation
Shanxi University
2018-2025
Qingdao University of Science and Technology
2022-2024
Shanxi Medical University
2022-2024
Shanxi University of Traditional Chinese Medicine
2018-2024
University of Illinois Chicago
2016-2022
Ashland (United States)
2016-2022
Xidian University
2022
Liaocheng People's Hospital
2014-2017
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2015
Shenyang Pharmaceutical University
2006-2015
Seven new indole alkaloids, bruceollines H–N (1–7), three quassinoids, yadanziolides T–V (10–12), and four known analogues, bruceolline E (8), F (9), bruceine D (13), yadanziolide B (14), were isolated from an ethanol extract of the stems Brucea mollis. The absolute configurations compounds 2 5 determined by comparison their experimental calculated ECD spectra. configuration compound 9 was using Mo2(OAc)4-induced CD analysis for first time. Compounds 10, 13, 14 exhibited cytotoxic activities...
Abstract It is a great challenge to induce the formation of RuP 4 phase and realize construction metal‐rich phase/phosphorus‐rich phase‐ruthenium phosphide heterostructure by directional regulation proportion P metal atoms. The ultra‐high conductivity Ru 2 excellent ability V‐doped absorb/desorb H* are confirmed density functional theory (DFT) calculations, which laid theoretical foundation for unique P/V‐RuP structure accelerate HER reaction kinetics. This work innovatively uses V‐doping...
Addressing the urgent need to develop novel drugs against drug-resistant Mycobacterium tuberculosis ( M. tb) strains, ecumicin (ECU) and rufomycin I (RUFI) are being explored as promising new leads targeting cellular proteostasis via caseinolytic protein ClpC1. Details of binding topology chemical mode (inter)action these cyclopeptides help drive further development potency-optimized entities drugs. ClpC1 tb constructs with mutations driving resistance ECU RUFI show reduced affinity by...
The water-splitting efficiency is improved by Ru/FeCoP heterointerface to drive dual-active site mechanism. η 100 of Ru@FeCoP are 0.0741 V for HER and 0.314 OER, which reduced 63.8% 55.2% over Pt/C RuO 2 , respectively.
Abstract Background According to traditional Chinese medicine (TCM), drugs supplementing the vital energy, Qi, can eliminate tumors by restoring host immunity. The objective of this study is investigate underlying immune mechanisms anti‐tumor activity associated with Qi‐supplementing herbs, specifically paired use Huangqi and Danggui. Methods Analysis compatibility regularity was conducted screen combination TCMs. Using MTT assay a transplanted tumor mice model, effects TCMs were...
Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease in which macrophages produce cytokines that enhance inflammation and contribute to the destruction of cartilage bone.Additive Sishen decoction (ASSD) widely used traditional Chinese medicine for treatment RA; however, its active ingredients mechanism therapeutic effects remain unclear.Methods: To predict key targets ASSD, we constructed "drug-ingredient-target-disease" protein-protein interaction networks.Gene...
Abstract Introduction: The second-generation BTK inhibitors (BTKis), e.g., zanu, acalabrutinib (acala), have further transformed the therapy landscape of chronic lymphocytic leukemia (CLL). However, acquired mutations in (mainly at position C481) results covalent BTKi resistance and disease progression. Non-covalent pirtobrutinib (pirto) can overcome C481 mutations, but is susceptible to other like recently described kinase impaired V416L L528W which both maintain downstream signaling....
(+)-Strebloside, a cardiac glycoside isolated from the stem bark of Streblus asper collected in Vietnam, has shown some potential for further investigation as an antineoplastic agent. A mechanistic study using vitro assay and molecular docking analysis indicated that (+)-strebloside binds inhibits Na+/K+-ATPase similar manner to digitoxin. Inhibition growth different high-grade serous ovarian cancer cells including OVCAR3, OVSAHO, Kuramochi, OVCAR4, OVCAR5, OVCAR8 resulted treatment with...
A new approach targeting aeroallergen sensing in the early events of mucosal immunity could have greater benefit. The CSF1-CSF1R pathway has a critical role trafficking allergens to regional lymph nodes through activating dendritic cells. Intervention this prevent allergen sensitization and subsequent Th2 allergic inflammation.To examine therapeutic effectiveness CSF1 CSF1R inhibition for blocking cell function aeroallergens.We adopted model chronic asthma induced by panel three naturally...
(+)-Digoxin (1) is a well-known cardiac glycoside long used to treat congestive heart failure and found more recently show anticancer activity. Several known cardenolides (2–5) two new analogues, (+)-8(9)-β-anhydrodigoxigenin (6) (+)-17-epi-20,22-dihydro-21α-hydroxydigoxin (7), were synthesized from 1 evaluated for their cytotoxicity toward small panel of human cancer cell lines. A preliminary structure–activity relationship investigation conducted indicated that the C-12 C-14 hydroxy groups...
Previous studies indicated that (+)-13a-(S)-Deoxytylophorinine (1) showed profound anti-cancer activities both in vitro and vivo could penetrate the blood brain barrier to distribute well tissues. CNS toxicity, one of main factors hinder development phenanthroindolizidines, was not obviously found 1. Based on its fascinating activities, thirty-four derivatives were designed, synthesized; their cytotoxic tested discover more excellent anticancer agents. Considering distinctive mechanism 1...
Novel glycyrrhizin (GL) derivatives were designed and synthesized by introducing various amine or amino acid residues into the carbohydrate chain at C-30. Their inhibitory effects on high-mobility group box 1 (HMGB1) evaluated using a cell-based lipopolysaccharide (LPS) induced tumor necrosis factor α (TNF-α) release study. Compounds 10, 12, 18-20, 23, 24, which had substituents introduced C-30, demonstrated moderate HMGB1 inhibition with ED₅₀ values ranging from 337 to 141 μM, are...
To investigate the effects of configuration on bioactivity, spirooliganones A and B their six diastereoisomers (1–8) were synthesized in 11 steps. The key benzopyran core was assembled by intermolecular [4 + 2] hetero-Diels–Alder cycloaddition between (−)-sabinene o-quinone methide, which generated from corresponding o-hydroxybenzyl alcohol. After establishing absolute configuration, inhibitory activities 1–8 against Coxsackie virus B3 evaluated, primary structure–activity relationships...