A5100612475- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Allergic Rhinitis and Sensitization
- Electrospun Nanofibers in Biomedical Applications
- RNA Interference and Gene Delivery
- Wound Healing and Treatments
- Food Allergy and Anaphylaxis Research
- Virus-based gene therapy research
- vaccines and immunoinformatics approaches
- Ferroptosis and cancer prognosis
- COVID-19 Clinical Research Studies
- Animal Virus Infections Studies
- Advanced biosensing and bioanalysis techniques
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Viral gastroenteritis research and epidemiology
- Computational Drug Discovery Methods
- Gastric Cancer Management and Outcomes
- CAR-T cell therapy research
- Antimicrobial Peptides and Activities
- Asthma and respiratory diseases
- Viral Infectious Diseases and Gene Expression in Insects
Sichuan University
2016-2025
State Key Laboratory of Biotherapy
2010-2025
Taizhou People's Hospital
2022-2025
Nanjing Medical University
2021-2025
Nantong University
2022-2025
Shandong First Medical University
2023-2025
Hubei University
2023-2025
Southern Medical University
2020-2025
West China Hospital of Sichuan University
2010-2025
State Key Laboratory of Pollution Control and Resource Reuse
2025
Abstract Cancer-associated fibroblasts (CAFs) are the predominant components of tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics across different types. Here, we perform pan-cancer analysis 226 samples 10 solid types to profile TME at single-cell resolution, illustrating commonalities/plasticity heterogenous CAFs. Activation trajectory major CAF is divided into three states, exhibiting distinct interactions...
Stimuli-responsive hydrogels possess unique advantages in drug delivery due to their variable performance and status based on the external environment. In present study, a dual-responsive (pH reactive oxygen species (ROS)) hydrogel was prepared realize release properties under inflammatory stimulation. By grafting 3-carboxy-phenylboronic acid gelatin molecular backbone cross-linking with poly(vinyl alcohol), we successfully synthesized inflammation-responsive drug-loaded after encapsulation...
Abstract Neoantigens are considered to be ultimate target of tumor immunotherapy due their high specificity and immunogenicity. Dendritic cell (DCs) vaccines based on neoantigens have exciting effects in treatment some malignant tumors a promising therapeutic modality. Lung cancer is lethal disease with the highest morbidity mortality rate world. Despite rapid development targeted therapy immune checkpoint inhibitors for lung recent years, efficacy still unsatisfactory overall. Therefore,...
Clinical staining and targeting CREB3L1 facilitates precise stratification a potential treatment strategy for thyroid cancer.
Abstract Chronic refractory wounds have become a severe threat to public health and are characterized by repeated bacterial infections, persistent hypoxia, abnormal immune regulation, obstruction of angiogenesis. However, current treatment strategies usually perform only one or two therapeutic functions cannot satisfy the dynamic complex demands chronic wound healing. Herein, versatile Schiff base borate ester cross‐linked glycopeptide hydrogel is prepared from phenylboronic acid‐grafted...
Abstract Signet-ring cell carcinoma (SRCC) has specific epidemiology and oncogenesis in gastric cancer, however, with no systematical investigation for prognostic genomic features. Here we report a systematic conducted 1868 Chinese cancer patients indicating that signet-ring cells content was related to multiple clinical characteristics treatment outcomes. We thus perform whole-genome sequencing on 32 pairs of SRC samples, identify frequent CLDN18-ARHGAP26/6 fusion (25%). With 797 additional...
The natural product berberine (BBR), present in various plants, arouses great interests because of its numerous pharmacological effects. However, the further development and application BBR had been hampered by poor oral bioavailability. In this work, we report on polymer–lipid hybrid nanoparticles (PEG–lipid–PLGA NPs) loaded with phospholipid complex using a solvent evaporation method for enhancing efficiency. advantage new drug delivery system is that BBR–soybean phosphatidylcholine...
Objective The systemic spread of colorectal cancer (CRC) is dominated by the portal system and exhibits diverse patterns metastasis without systematical genomic investigation. Here, we evaluated evolution CRC with multiorgan metastases using multiregion sequencing. Design Whole-exome sequencing was performed on multiple regions (n=74) matched primary tumour, adjacent non-cancerous mucosa, liver lung from six patients CRC. Phylogenetic reconstruction evolutionary analyses were used to...
Abstract COVID-19 is caused by SARS-CoV-2, and has become a global pandemic. There no highly effective medicine or vaccine, most of the patients were recovered their own immune response, especially virus specific IgG IgM responses. However, IgG/ responses barely known. To enable understanding SARS-CoV-2 responses, proteome microarray with 18 out 28 predicted proteins was constructed. The applied to profile 29 convalescent sera. results suggest that at phase 100% had protein N, S1 but not S2....
The outbreak of coronavirus (SARS-CoV-2) disease caused more than 100,000,000 people get infected and over 2,200,000 being killed worldwide. However, the current developed vaccines or drugs may be not effective in preventing pandemic COVID-19 due to mutations severe side effects newly vaccines. Chinese herbal medicines their active components play important antiviral activities. Corilagin exhibited effect on human immunodeficiency virus (HIV), hepatitis C (HCV) Epstein-Barr (EBV). whether it...
Abstract The recently emerged Omicron (B.1.1.529) variant has rapidly surpassed Delta to become the predominant circulating SARS-CoV-2 variant, given higher transmissibility rate and immune escape ability, resulting in breakthrough infections vaccinated individuals. A new generation of vaccines targeting are urgently needed. Here, we developed a subunit vaccine named RBD-HR/trimer by directly linking sequence RBD derived from (containing L452R T478K) HR1 HR2 S2 tandem manner, which can...
Nowadays, diabetic chronic wounds impose a heavy burden on patients and the medical system. Persistent inflammation poor tissue remodeling severely limit healing of wounds. For these issues, first recombinant humanized collagen type III (rhCol III) naproxen (Nap) loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticle incorporated hyaluronic acid (HA) microneedle (MN) was fabricated for wound therapy. As tailored rhCol synthesized based Gly483-Pro512 segment, which contained highly adhesive...
Abstract The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants. In Chengdu, China, an infection wave was predominantly induced by BA.5 subvariant. It is crucial determine whether hybrid anti-SARS-CoV-2 immunity following infection, coupled with a variety immune background, sufficient shape responses against newly emerged subvariants, especially for XBB lineages. To investigate this, we...
Abstract The clinical efficacy of personalized cancer vaccines still needs to be improved due their insufficient immune effect. development innovative adjuvants and lymph node‐targeted delivery systems is the key improving vaccines. However, there a lack an adjuvant system that simple in preparation capable mass production integrates node targeted functions. Here, this work reports dendrimer polypeptide (KK2DP7) nanoparticle enhances OVA/neoantigen‐based vaccine. Due its multiple functions...
Abstract Mucosal immunity plays a significant role in the first-line defense against viruses transmitted and infected through respiratory system, such as SARS-CoV-2. However, lack of effective safe adjuvants currently limits development COVID-19 mucosal vaccines. In current study, we prepare an intranasal vaccine containing cationic crosslinked carbon dots (CCD) SARS-CoV-2 antigen, RBD-HR with spontaneous antigen particlization. Intranasal immunization CCD/RBD-HR induces high levels...
Abstract The newly emerged variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) demonstrate resistance to present therapeutic antibodies as well the capability evade vaccination-elicited antibodies. JN.1 sublineages were demonstrated one most immune-evasive variants, showing higher neutralization compared XBB.1.5. In this study, serum samples collected from adult participants including those who had gone through BA.5/BF.7, EG.5/HK.3 and XBB/JN.1 infection waves,...
Abstract The emergence of XBB- and JN.1-lineages with remarkable immune evasion characteristics have led to rises in breakthrough infections within populations. In addition, the unfavorable impacts imprinting, stemming from continuous exposure antigens circulated viruses, been observed incline response against earlier lineages, thereby declining neutralization newly emerged Omicron subvariants. this, advancement next-generation vaccines COVID-19 targeting components new subvariants such as...