A5052503892- 3D Printing in Biomedical Research
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Nerve injury and regeneration
- Additive Manufacturing and 3D Printing Technologies
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Bone Tissue Engineering Materials
- biodegradable polymer synthesis and properties
- Advancements in Transdermal Drug Delivery
- Magnolia and Illicium research
- Electrospun Nanofibers in Biomedical Applications
- Cancer Research and Treatments
- Neuroscience and Neural Engineering
- Innovative Microfluidic and Catalytic Techniques Innovation
- Wound Healing and Treatments
- Polydiacetylene-based materials and applications
- Antimicrobial Peptides and Activities
- Ocular Surface and Contact Lens
- Extracellular vesicles in disease
- Pharmacological Effects of Natural Compounds
- Ginkgo biloba and Cashew Applications
- Dermatology and Skin Diseases
- Hydrogels: synthesis, properties, applications
Sichuan University
2016-2025
State Key Laboratory of Biotherapy
2016-2025
Cornell University
2020
Case Western Reserve University
2020
University of Leeds
2020
Chengdu University
2014-2019
University of California, San Diego
2018
West China Medical Center of Sichuan University
2014-2018
Zhejiang University
2018
Ministry of Education of the People's Republic of China
2012
Curcumin is an effective and safe anticancer agent, but its hydrophobicity inhibits clinical application. Nanotechnology provides method to improve the water solubility of hydrophobic drug. In this work, curcumin was encapsulated into monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) micelles through a single-step nano-precipitation method, creating curcumin-loaded MPEG-PCL (Cur/MPEG-PCL) micelles. These Cur/MPEG-PCL were monodisperse (PDI = 0.097 ± 0.011) with mean particle...
Rationally designed nanoparticles that can bind toxins show great promise for detoxification. However, the conventional intravenous administration of detoxification often leads to nanoparticle accumulation in liver, posing a risk secondary poisoning especially liver-failure patients. Here we present liver-inspired three-dimensional (3D) device. This device is created by 3D printing designer hydrogels with functional polydiacetylene installed hydrogel matrix. The attract, capture and sense...
Three-dimensional (3D) printing technology has great potential in advancing clinical medicine. Currently, the vivo application strategies for 3D-printed macroscale products are limited to surgical implantation or situ 3D at exposed trauma, both requiring exposure of site. Here, we show a digital near-infrared (NIR) photopolymerization (DNP)-based that enables noninvasive bioprinting tissue constructs. In this technology, NIR is modulated into customized pattern by micromirror device, and...
Nanocarriers with positive surface charges are known for their toxicity which has limited clinical applications. The mechanism underlying toxicity, such as the induction of inflammatory response, remains largely unknown. In present study we found that injection cationic nanocarriers, including liposomes, PEI, and chitosan, led to rapid appearance necrotic cells. Cell necrosis induced by nanocarriers is dependent on charges, but does not require RIP1 Mlkl. Instead, intracellular Na+ overload...
Encapsulation of hydrophobic agents in polymer micelles can improve the water solubility cargos, contributing to develop novel drugs. Quercetin (QU) is a agent with potential anticancer activity. In this work, we encapsulated QU into biodegradable monomethoxy poly(ethylene glycol)-poly(ε-caprolactone) (MPEG-PCL) and tried provide proof-of-principle for treating ovarian cancer nano-formulation quercetin. These loaded MPEG-PCL (QU/MPEG-PCL) drug loading 6.9% had mean particle size 36 nm,...
Tissue engineered conduits have great promise for bridging peripheral nerve defects by providing physical guiding and biological cues. A flexible method integrating support cells into a conduit with desired architectures is wanted. Here, 3D-printing technology adopted to prepare bio-conduit designer structures regeneration. This consisted of cryopolymerized gelatin methacryloyl (cryoGelMA) gel cellularized adipose-derived stem (ASCs). By modeling using 3D-printed "lock key" moulds, the...
Biofabrication of personalized titanium scaffold mimicking that the osteocyte microenvironment is challenging due to its complex geometrical cues. The effect scaffolds cues and implantation sites on osteogenesis still not clear. In this study, with homogeneous diamond-like structures were precisely designed fabricated by selected laser melting method. effects different geometric cues, including porosity, pore sizes interconnection properties, cellular behavior investigated. Biomimetic...
Cisplatin-based chemotherapy remains the primary treatment for unresectable and metastatic muscle-invasive bladder cancers (MIBCs). However, tumors frequently develop chemoresistance. Here, we established a orthotopic MIBC mouse model with gene-edited organoids to recapitulate full course of in patients. We found that partial squamous differentiation, called semi-squamatization, is associated acquired chemoresistance both mice human MIBCs. Multi-omics analyses showed cathepsin H (CTSH)...
Nerve guide conduit is a promising treatment for long gap peripheral nerve injuries, yet its efficacy limited. Drug-releasable scaffolds may provide reliable platforms to build regenerative microenvironment recovery. In this study, an elastic hydrogel encapsulating with prodrug nanoassemblies fabricated by continuous 3D printing technique promoting regeneration. The bioactive comprised of gelatin methacryloyl (GelMA) and silk fibroin glycidyl methacrylate (SF-MA), exhibiting positive effects...
Abstract 3D‐printed cell‐laden hydrogels as tissue constructs show great promise in generating living tissues for medicine. Currently, the maturation of into remains challenge, since commonly used struggle to provide an ideal microenvironment seeded cells. In this study, a cell‐adaptable nanocolloidal hydrogel is created 3D printing maturable constructs. The composed interconnected nanoparticles, which prepared by self‐assembly and subsequent photocrosslinking gelatin methacryloyl solutions....