A5087340581- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Inflammasome and immune disorders
- SARS-CoV-2 and COVID-19 Research
- Medicinal Plants and Bioactive Compounds
- Immune cells in cancer
- COVID-19 Clinical Research Studies
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- Gout, Hyperuricemia, Uric Acid
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- interferon and immune responses
Sichuan University
2022-2023
State Key Laboratory of Biotherapy
2022-2023
Abstract The COVID-19 response strategies in Chinese mainland were recently adjusted due to the reduced pathogenicity and enhanced infectivity of Omicron subvariants. In Chengdu, China, an infection wave was predominantly induced by BA.5 subvariant. It is crucial determine whether hybrid anti-SARS-CoV-2 immunity following infection, coupled with a variety immune background, sufficient shape responses against newly emerged subvariants, especially for XBB lineages. To investigate this, we...
Abstract mRNA vaccines have emerged rapidly in recent years as a prophylactic and therapeutic agent against various diseases including cancer infectious diseases. Improvements of been underway, among which boosting efficacy is great importance. Pam2Cys, simple synthetic metabolizable lipoamino acid that signals through Toll-like receptor (TLR) 2/6 pathway, eliciting both humoral cellular adaptive immune responses, an interesting candidate adjuvant. To investigate the enhancement efficacies...
Abstract Neutrophil is a pathophysiological character in Alzheimer's disease. The pathogen for neutrophil activation cerebral tissue the accumulated amyloid protein. In our present study, neutrophils infiltrate into cerebra two models (transgenic model APP/PS1 and stereotactic injection model) promote neuron apoptosis, releasing their cellular constituents, including mitochondria mitochondrial DNA (mtDNA). We found that both Aβ 1–42 mtDNA could provoke infiltration cerebra, they had...
Abstract BA.4 and BA.5 (BA.4/5), the subvariants of Omicron, are more transmissible than BA.1 with robust immune evasion capability because its unique spike protein mutations. In light such situation, vaccination against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is in desperate need third booster. It has been reported that heterologous boosters might produce effective immunity wild‐type SARS‐CoV‐2 variants. Additionally, subunit booster should be considered potentially....
<b>Aim:</b> Gastric cancer (GC) is one of the most common malignant tumors. Chrysophanol has been reported to possess antitumor effects on a variety cancers; however, its role in GC remains unclear. This study aimed investigate chrysophanol proliferation, pyroptosis, migration, and invasion cells. <b>Methods:</b> Human cell lines MKN 28 AGS cells were treated with different concentrations chrysophanol, then pyroptosis determined by CCK-8, colony-forming assay, wound healing Transwell flow...