A5046394427- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Acute Myeloid Leukemia Research
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Acute Lymphoblastic Leukemia research
- Single-cell and spatial transcriptomics
- Retinoids in leukemia and cellular processes
- Cancer-related gene regulation
- Extracellular vesicles in disease
- Reproductive System and Pregnancy
- Advanced battery technologies research
- T-cell and B-cell Immunology
- Neutropenia and Cancer Infections
- Vasculitis and related conditions
- Cancer Cells and Metastasis
- Biliary and Gastrointestinal Fistulas
- Glioma Diagnosis and Treatment
- Immune cells in cancer
- Colorectal and Anal Carcinomas
- Lymphoma Diagnosis and Treatment
- Cancer Mechanisms and Therapy
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
West China Hospital of Sichuan University
2020-2025
Sichuan University
2020-2025
Sun Yat-sen University
2008-2024
The First Affiliated Hospital, Sun Yat-sen University
2018-2024
State Key Laboratory of Biotherapy
2022-2024
Abstract Cancer-associated fibroblasts (CAFs) are the predominant components of tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics across different types. Here, we perform pan-cancer analysis 226 samples 10 solid types to profile TME at single-cell resolution, illustrating commonalities/plasticity heterogenous CAFs. Activation trajectory major CAF is divided into three states, exhibiting distinct interactions...
Intravenous arsenic trioxide (ATO) has been adopted as the first-line treatment for acute promyelocytic leukemia (APL). Another compound named Realgar-Indigo naturalis formula (RIF), an oral traditional Chinese medicine containing As4 S4 , shown to be highly effective in treating adult APL. In of pediatric APL, safety and efficacy RIF remains confirmed. This randomized, multicenter, noninferiority trial was conducted determine whether intravenous ATO can substituted by From September 2011...
Ileum-ileum-colon intussusception constitutes a small proportion of the classification intussusception. Both adult and Meckel's diverticulum are rare clinical entities, with few reports documenting inversion leading to ileum-ileum-colon in adults. A 33-year-old Chinese male presented intermittent abdominal pain persisting for 1 month, that had intensified over preceding day. Abdominal computed tomography revealed intussusception, suspected be secondary intestinal lipoma. Emergency laparotomy...
Numerous patients with rheumatoid arthritis (RA) manifest severe syndromes, including elevated synovial fluid volumes (SF) abundant immune cells, which can be controlled by TNF/JAK inhibitors. Here, we apply single-cell RNA sequencing (scRNA-seq) and subsequent validations in SF from RA patients. These analyses of tissue show reduced density SF-derived pathogenic cells (e.g., SPP1+ macrophages CXCL13+CD4+ T cells), altered gene expression SPP1 STAT1), molecular pathway changes JAK/STAT),...
<p>Pearson correlation of screened factors</p>
<p>Patients were divided into three groups based on the percentages of CD8+ T cells</p>
<p>Analysis of immune cell statuses across different tumor locations in training and validation cohorts.</p>
<p>Abs for mIHC staining</p>
<p>Clinical characteristics of patients from TMA study</p>
<p>Spatial phenotypes of CD8+ T cells</p>
<p>Abs for FACS analysis</p>
<p>Clinical characteristics of training and validation cohorts</p>
<p>Immune cell status changes after αPD-1 + αTIM-3 treatment</p>
<p>Workflow of mIHC analysis</p>
<p>Comparative analysis of CD8+ cell subtypes distribution across spatial clusters in unsupervised groupings</p>
Abstract Introduction Anastomotic leakage (AL) remains the most dreaded and unpredictable major complication after low anterior resection for mid‐low rectal cancer. The aim of this study is to identify patients with high risk AL based on machine learning method. Methods Patients cancer undergoing were enrolled from West China Hospital between January 2008 October 2019 split by time into training cohort validation cohort. least absolute shrinkage selection operator (LASSO) method stepwise...
Abstract There are challenges for diagnosis and treatment of idiopathic pulmonary hemosiderosis (IPH). This clinical trial was to review the evaluate efficacy maintenance therapy with dose‐adjusted 6‐mercaptopurine (6MP) in IPH children. Fifteen children were enrolled. Prednisone administered at 2 mg/kg/day 4 weeks acute phase disease followed by taper. 6MP also started 60 mg/m /day simultaneously continued 3 years outpatient. The delay is common probably due a lack classical triad most All...
Abstract Objective Acute promyelocytic leukemia (APL) is now highly curable, except in many developing countries. Introduction of current treatment strategies may improve the outcome for children with APL these Methods The diagnosis was based on FAB classification and detection PML‐RARα rearrangement. From December 1999 to September 2004, 16 eligible were treated an intensive in‐house protocol including high‐dose AraC anthracycline. Subsequently, 14 cases a less modified from PETHEMA LPA99....
Abstract Objective Treatment and outcome of infant acute leukemia (IAL) in developed countries have been well documented. However, reports summarizing diagnosis IAL developing are limited. Methods Five hundred ninety seven pediatric patients were diagnosed with our hospital between January 1997 June 2008, which 19 younger than 12 months. Data from cases the Chinese literature analyzed. Results Of cases, 14 had lymphoblastic (ALL) 5 myeloid (AML) based on FAB classification. Immunophenotyping...
Background: Pediatric acute myeloid leukemia (AML) has poor prognosis and high rate of relapse mortality, exploration new treatment options is still critically needed. Objectives: To summarize the outcome our strategies for pediatric AML, which characterized by dual induction lymphoblastic (ALL) elements consolidation. Design: Retrospective, single-arm study. Methods: From July 2012 to December 2019, an intensive chemotherapy protocol was used newly diagnosed children with contains...
The identification of specific spatial patterns immune checkpoint expression that correlate with overall survival in patients colon cancer suggests a potential prognostic tool for risk stratification and treatment selection. These findings pave the way development novel therapeutic strategies to enhance antitumor responses.
<p>Abs for FACS analysis</p>
<p>Spatial heterogeneity of the immune microenvironment correlates with patient prognosis in human colorectal cancer. <b>A,</b> Representative images defined seven cell types (CD8<sup>+</sup>PD-1<sup>+</sup>TIM-3<sup>+</sup>, CD8<sup>+</sup>PD-1<sup>+</sup>TIM-3<sup>−</sup>, CD8<sup>+</sup>PD-1<sup>−</sup>TIM-3<sup>−</sup>,...
<p>Analysis of immune cell statuses across different tumor locations in training and validation cohorts.</p>