A5100330658- Gout, Hyperuricemia, Uric Acid
- COVID-19 Clinical Research Studies
- Dialysis and Renal Disease Management
- Viral gastroenteritis research and epidemiology
- Chronic Kidney Disease and Diabetes
- Acute Kidney Injury Research
- Sepsis Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Long-Term Effects of COVID-19
- Case Reports on Hematomas
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Function and Risk Factors
- Natural product bioactivities and synthesis
- Acute Ischemic Stroke Management
- Salivary Gland Disorders and Functions
- Viral Infections and Outbreaks Research
- Renal Diseases and Glomerulopathies
- Pulmonary Hypertension Research and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- COVID-19 epidemiological studies
- Advanced Proteomics Techniques and Applications
- Inflammasome and immune disorders
Sichuan University
2009-2025
West China Hospital of Sichuan University
2009-2025
Beijing Proteome Research Center
2022-2025
Qingdao Binhai University
2025
Anyang Eye Hospital
2025
Tsinghua University
2020-2024
Nanchang Center for Disease Control and Prevention
2024
State Key Laboratory of Infectious Disease Prevention and Control
2024
Wuhan University
2022
Wenzhou Medical University
2019-2022
Among patients with end-stage renal disease who are treated hemodialysis, solute clearance during dialysis and nutritional adequacy determinants of mortality. We determined the effects reductions in blood urea nitrogen concentrations changes serum albumin concentrations, as an indicator status, on mortality a large group hemodialysis.We analyzed retrospectively demographic characteristics, rate, duration concentration, reduction ratio (defined percent concentration single treatment) 13,473...
Abstract Cancer-associated fibroblasts (CAFs) are the predominant components of tumor microenvironment (TME) and influence cancer hallmarks, but without systematic investigation on their ubiquitous characteristics across different types. Here, we perform pan-cancer analysis 226 samples 10 solid types to profile TME at single-cell resolution, illustrating commonalities/plasticity heterogenous CAFs. Activation trajectory major CAF is divided into three states, exhibiting distinct interactions...
Metformin was proposed to be a candidate for host-directed therapy COVID-19. However, its efficacy remains validated. In this study, we compared the outcome of metformin users and nonusers in hospitalized COVID-19 patients with diabetes. Hospitalized diabetic confirmed Tongji Hospital Wuhan, China, from January 27, 2020 March 24, 2020, were grouped into no-metformin groups according medications used. The demographics, characteristics, laboratory parameters, treatments, clinical these...
Facing the ongoing coronavirus infectious disease-2019 (COVID-19) pandemic, many studies focus on severe acute respiratory syndrome 2 (SARS-CoV-2) in indoor environment, solid surface or wastewater. It remains unclear whether SARS-CoV-2 can spill over into outdoor environments and impose transmission risks to surrounding people communities. In this study, we investigated presence of by measuring viral RNA 118 samples from environment three hospitals Wuhan. We detected soils (205–550...
Abstract Aim Febuxostat, a novel non‐purine selective inhibitor of xanthine oxidase, has been identified as potential alternative to allopurinol in patients with hyperuricemia. The purpose this study was compare the urate‐lowering ( UL ) efficacy and safety daily febuxostat C hinese gout Methods Gout n = 512) serum uric acid (s UA concentrations at least 8.0 mg/dL were randomized receive 40 mg or 80 300 for 28 weeks. Prophylaxis against flares meloxicam colchicine provided during weeks 1...
Objectives Primary Sjögren's syndrome (pSS) is an important cause of pulmonary arterial hypertension (PAH), which remains insufficiently studied and needs attention. This study aimed to investigate the clinical characteristics, risk factors, prognosis assessment pSS-PAH. Methods We established a multicentre cohort pSS-PAH diagnosed by right heart catheterisation. The case–control was conducted with pSS-non-PAH patients as control group identify factors for PAH. In study, survival calculated,...
Homogeneous analysis techniques offer several advantages as alternatives to heterogeneous immunoassays, such simplicity and rapidity. In this study, a visual homogeneous immunoassay without labeling process was developed based on target-induced steric hindrance regulate competitive recognition mechanism. Specifically, the analyte concentration varies, change of microenvironment could affect Cu2+ by signal probes. Herein, taking anticyclic citrullinated peptide antibody (anti-CCP) an example,...
Abstract Objective To compare the efficacy of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification (CPS) in treating postvitrectomy cataracts. Methods Prospective randomized controlled study. Patients who underwent after pars plana vitrectomy (PPV) were randomly divided into FLACS group CPS group. Preoperative data all patients collected to intraoperative complications, average energy (AVE), effective time (EPT), postoperative intraocular pressure, corneal...
Objective This study investigates the relationship between media usage patterns and anxiety levels, specifically examining how different profiles influence across various demographic groups. Methodology A total of 11,031 respondents from 120 cities China were classified into three profiles—Traditional Media-Dominant Users, New Omni-Media Users—using Latent Profile Analysis (LPA) based on their frequency. Demographic covariates excluded during initial profiling to ensure analysis focused...
M-type phospholipase A2 receptor (PLA2R) is the major target antigen in primary membranous nephropathy (PMN). Previous studies have evaluated diagnostic value of serum anti-PLA2R antibody. However, correlation antibody and glomerular PLA2R deposition, their association with clinical characteristics need to be further evaluated.A total 136 patients were involved as inception group because simultaneously measured. We examined by ELISA deposition immunofluorescence assay.Positive seen 58.8%...
Primary membranous nephropathy (PMN) is an important cause of nephrotic syndrome in adults. Urine proteome may provide clues pathophysiological mechanisms PMN. In the current study, we analyzed and compared urine from patients with PMN normal controls.We performed two technical replicates (TMT1 TMT2) to analyze compare controls by tandem mass tag (TMT) technology coupled nanoscale liquid chromatography spectrometry analysis (LC-MS/MS). Gene ontology (GO) enrichment was analyse general...
The aim of the present study was to explore role ataxia‑telangiectasia mutated (ATM) in lipopolysaccharide (LPS)‑induced vitro model septic acute kidney injury (AKI) and association between ATM, tubular epithelial inflammatory response autophagy. renal cell HK‑2 line cultured passaged, with induced by LPS. effects LPS on morphology, viability, ATM expression inflammation were observed. Lentiviral vectors encoding shRNA constructed knock down cells. efficiency knockdown cells detected western...
Rheumatoid arthritis (RA) is a typical autoimmune disease characterized by synovial inflammation, tissue hyperplasia, and destruction of bone cartilage. Protein glycosylation plays key roles in the pathogenesis RA but in-depth glycoproteomics analysis tissues still lacking. Here, using strategy to quantify intact N-glycopeptides, we identified 1260 N-glycopeptides from 481 N-glycosites on 334 glycoproteins synovium. Bioinformatics revealed that hyper-glycosylated proteins were closely linked...
This study aims to investigate the effects of raw materials and drying methods on phytochemical antioxidant capacities instant sweet tea powder. Four leave powders (STUT) were extracted dried with two (freeze-drying spray-drying). The capacity, total phenolic content (TPC), flavonoid (TFC), phlorizin trilobatin contents obtained compared. In addition, single-factor experiments coupled response surface methodology used influences solvent-to-sample ratio, extraction temperature, time, their...
Primary Sjogren's syndrome (SS) is a chronic inflammatory disease with unknown aetiology. Although clonal expansion of autoreactive T cells has been identified in patients SS, the clinical correlation T-cell receptor (TCR) variance SS remains unclear.TCRβ repertoire sequencing was performed on 260 3-6 months follow-up cohort study to dynamically assess characteristics TCR diversity and their significance.We found that had lower diversity, but higher frequency public clones than healthy...