A5100402884- Cancer-related molecular mechanisms research
- Dementia and Cognitive Impairment Research
- Connexins and lens biology
- MicroRNA in disease regulation
- RNA modifications and cancer
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Frailty in Older Adults
- Mitochondrial Function and Pathology
- Bioinformatics and Genomic Networks
- Neurological Disease Mechanisms and Treatments
- Schizophrenia research and treatment
- Health, Environment, Cognitive Aging
- Glaucoma and retinal disorders
- RNA Research and Splicing
- Intraocular Surgery and Lenses
- Cancer, Lipids, and Metabolism
- COVID-19 and Mental Health
- Effects and risks of endocrine disrupting chemicals
- Heme Oxygenase-1 and Carbon Monoxide
- NF-κB Signaling Pathways
- Lipid metabolism and disorders
- Moyamoya disease diagnosis and treatment
- Redox biology and oxidative stress
- Patient Dignity and Privacy
Huazhong University of Science and Technology
2021-2025
Zhongda Hospital Southeast University
2025
Anyang Eye Hospital
2025
Tongji Hospital
2025
Xizang Minzu University
2025
Hunan Provincial Center for Disease Control and Prevention
2024
Union Hospital
2024
Central South University
2023-2024
Xiangya Hospital Central South University
2023-2024
Qiqihar Medical University
2024
Many histopathologic parameters in squamous cell carcinoma of the tongue have been identified as predictive factors for cervical lymph metastasis. However, occult node metastases and criterion elective therapy remain inconclusive. This study analyzed clinicopathologic associated with late patients tongue.The features 50 consecutive seen between January 1985-December 1996 previously untreated stage I or II were reviewed. All treated partial glossectomy without neck dissection. Their mean age...
Cx36 is the predominant connexin isoform expressed by pancreatic β-cells. However, little known about role of this protein in functioning insulin-secreting cells. To address question, we searched for a cell line expressing and having glucose-induced insulin secretion comparable to that primary By evaluating expression MIN6, βTC3, RIN2A, INS1, HIT lines, which differ their sensitivity glucose, found wild-type MIN6 cells fit these requirements. Therefore, stably transfected with cDNA coding...
Abstract The objective of the study was to investigate expression and functions CASC 9 in esophageal squamous cell carcinoma ( ESCC ). Long noncoding RNA s (lnc s) upregulated tissues were detected by sequencing. Expression determined from clinical samples lines qRT ‐ PCR . effects knockdown on migration invasion evaluated wound healing assay, assays vitro. We found that lnc , 9, markedly tissues. Furthermore, significantly suppressed enhanced level correlated with differentiation. results...
Considerable evidence suggest that a variety of Long-non-coding RNAs (LncRNAs) are widely implicated in several neurodegenerative disorders. The present study aims to investigate the regulatory effect LncRNA 17A an vitro model Alzheimer's disease (AD). AD cell was established by treating SH-SY5Y cells with amyloid β peptide 1-42, and then were transfected shRNA pcDNA-17A. Apoptosis, migration, invasion ELISA assays performed differentiated expression level on line. It determined...
Abstract Background Cancer stem cells (CSCs) and long non-coding RNAs (lncRNAs) are known to play a crucial role in the growth, migration, recurrence, drug resistance of tumor cells, particularly triple-negative breast cancer (TNBC). This study aims investigate stemness-related lncRNAs (SRlncRNAs) as potential prognostic indicators for TNBC patients. Methods Utilizing RNA sequencing data corresponding clinical information from TCGA database, employing Weighted Gene Co-expression Network...
Abstract Atopic dermatitis (AD) is a chronic inflammatory disease associated with immune dysfunction. High levels of reactive oxygen species (ROS) can lead to oxidative stress, release pro-inflammatory cytokines, and T-cell differentiation, thereby promoting the onset worsening AD. In this study, we innovatively used quaternary ammonium chitosan (QCS) tannic acid (TA) as raw materials design prepare therapeutic hydrogel(H-MnO 2 -Gel) loaded hollow manganese dioxide nanoparticles (H-MnO NPs)....
Endothelial cell (EC) dysfunction induces atherosclerotic coronary heart disease (CHD) development. Recent studies demonstrated that lncRNA NEAT1 mediates multiple biological functions of cells. How regulates EC function is still unclear, so this study explored the role and mechanism in oxidative stress-induced ECs. The levels miR-181d-5p were measured serum samples from ApoE−/− mice t-BHP-treated human umbilical vein endothelial cells (HUVECs) by qRT-PCR. potential viability, migration...
Abstract Objective To compare the efficacy of femtosecond laser-assisted cataract surgery (FLACS) and conventional phacoemulsification (CPS) in treating postvitrectomy cataracts. Methods Prospective randomized controlled study. Patients who underwent after pars plana vitrectomy (PPV) were randomly divided into FLACS group CPS group. Preoperative data all patients collected to intraoperative complications, average energy (AVE), effective time (EPT), postoperative intraocular pressure, corneal...
Importance Tetramethylpyrazine nitrone has exhibited promising results in improving motor dysfunction neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). Objective To evaluate the safety and efficacy of orally administered tetramethylpyrazine patients with ALS. Design, Setting, Participants This phase 2, multicenter, double-masked, placebo-controlled, randomized clinical trial was conducted from December 24, 2020, through July 14, 2023, 11 centers China, a 180-day...
Abstract Background Large amounts of mammalian protein-protein interaction (PPI) data have been generated and are available for public use. From a systems biology perspective, Proteins/genes interactions encode the key mechanisms distinguishing disease health, such can be uncovered through network analysis. An effective analysis tool should integrate different content-specific PPI databases into comprehensive format with user-friendly platform to identify functional modules/pathways...
Diabetic cardiomyopathy (DCM) is one of the primary complications cardiovascular system due to diabetes‑induced metabolic injury. The present study investigated autophagy‑associated regulatory mechanisms long non‑coding RNAs in cardiac pathological changes diabetes mellitus (DM). Streptozotocin (STZ)‑induced diabetic rats were intramyocardially injected and high concentration glucose (HG)‑processed H9C2 cells infected with growth arrest specific transcript 5 (GAS5)‑loaded AAV‑9 adenovirus....
The intratumor heterogeneity of human papillomavirus (HPV)-related cervical cancer remains poorly defined. We performed single-cell RNA sequencing on 18 046 individual cells derived from two HPV-related adenosquamous carcinoma samples to analyze the transcriptional both epithelial and immune constituents, identifying seven (Epi1-7) 11 subclusters. Based expression known markers, Epi1-2 primarily displayed features adenocarcinoma, whereas Epi3-6 were instead characterized by squamous...
Earlier studies showed that human lens ALDH1A1 plays a critical role in protection against oxidative stress-induced cytotoxicity epithelial cells (HLEC), and opacification of rat mouse lens. The complete coding sequence was cloned from cDNA library by using PCR methods expressed it Escherichia coli. encodes 501-amino-acid protein (molecular mass = 54.8 kD) is 100% identical to liver shares significant identity with the same isozyme other tissues species. purified recombinant exhibited...