A5065162774- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Trace Elements in Health
- Neurological diseases and metabolism
- Neurogenetic and Muscular Disorders Research
- Hereditary Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- Alzheimer's disease research and treatments
- Heavy Metal Exposure and Toxicity
- Metabolism and Genetic Disorders
- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Epilepsy research and treatment
- Multiple Sclerosis Research Studies
- DNA Repair Mechanisms
- RNA regulation and disease
- Iron Metabolism and Disorders
- Prion Diseases and Protein Misfolding
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Aluminum toxicity and tolerance in plants and animals
- RNA modifications and cancer
- Cardiomyopathy and Myosin Studies
Second Affiliated Hospital of Zhejiang University
2016-2025
Zhejiang Lab
2021-2025
Center for Excellence in Brain Science and Intelligence Technology
2019-2025
Children's Hospital of Fudan University
2025
Gannan Normal University
2025
Zhejiang University
2015-2024
Sun Yat-sen University
2023-2024
Beijing Chest Hospital
2024
Capital Medical University
2024
Zhejiang Medicine (China)
2024
Microglia continuously survey the brain parenchyma and actively shift status following stimulation. These processes demand a unique bioenergetic programme; however, little is known about metabolic determinants in microglia. By mining large datasets generating transgenic tools, here we show that hexokinase 2 (HK2), most active isozyme associated with mitochondrial membrane, selectively expressed microglia brain. Genetic ablation of HK2 reduced microglial glycolytic flux energy production,...
•In-depth proteomics workflow for profiling paired cerebrospinal fluid (CSF) and serum proteomes.•Independent multicenter set combined with multiple methods validation.•Development of 19 CSF- 8 serum-protein panels early Alzheimer disease (AD) diagnosis.•Twenty-one CSF 18 proteins dysregulated in different AD stages.•Groundwork laid blood tests clinical screening staging. Amyloid-β, tau pathology, biomarkers neurodegeneration make up the core diagnostic (AD). However, these represent only a...
Near-infrared upconversion chemodosimetry is a promising detection method by virtue of the frequency technique, which shows very high sensitivity and selectivity for Cu(2+) ions in vitro vivo. This offers new opportunity noninvasive diagnosis Wilson disease associated with clinical medicine.
Mutations in the proline-rich transmembrane protein 2 (PRRT2) are associated with paroxysmal kinesigenic dyskinesia (PKD) and several other neurological diseases, but PRRT2 function pathogenic mechanisms remain largely obscure. Here we show that is a presynaptic interacts components of SNARE complex downregulates its formation. Loss-of-function mutant mice showed PKD-like phenotypes triggered by generalized seizures, hyperthermia, or optogenetic stimulation cerebellum. Mutant specific...
Abstract Background Spinocerebellar ataxia type 3 (SCA3) is the most common subtype of autosomal dominantly inherited spinocerebellar ataxias (SCAs). No validated blood biomarker available to assess either disease progression or therapeutic response. Neurofilament light chain (NfL) was recently proposed as a serum for many neurodegenerative disorders. The present study investigated whether NfL promising SCA3. Methods Seventeen SCA3 patients and 9 controls were enrolled in cohort A, 116...
The P-type ATPase ATP7B exports cytosolic copper and plays an essential role in the regulation of cellular homeostasis. Mutants cause Wilson disease (WD), autosomal recessive disorder metabolism. Here, we present cryoelectron microscopy (cryo-EM) structures human E1 state apo, putative copper-bound, cisplatin-bound forms. In ATP7B, N-terminal sixth metal-binding domain (MBD6) binds at entry site transmembrane (TMD), facilitating delivery from MBD6 to TMD. sulfur-containing residues TMD mark...
Discrepancies in diagnostic biomarkers for Alzheimer's Disease (AD) may arise from racial disparities, risk factors, or lifestyle differences. Moreover, there has been a lack of systematic and multicenter studies to evaluate baselines the AD Chinese populations. Thus, is an urgent need research investigate effectiveness blood AD, specifically Han population, using approach. In present multicenter-based cross-sectional longitudinal study, we evaluated 817 samples 6 different clinical centers....
Epstein‒Barr virus (EBV)-associated gastric cancer (GC) manifests an intriguing immunotherapy response. However, the cellular basis for EBV-imprinted tumour immunity and on-treatment response remains undefined. This study aimed to finely characterize dynamic immune contexture of human EBV (+) GC treated with immunochemotherapy by longitudinal scRNA-seq paired scTCR/BCR-seq. exhibits inflamed-immune phenotype increased T-cell B-cell infiltration. Immunochemotherapy triggers clonal revival...
Abstract The blood brain barrier (BBB) limits the application of most therapeutic drugs for neurological diseases (NDs). Hybrid cell membrane‐coated nanoparticles derived from different types can mimic surface properties and functionalities source cells, further enhancing their targeting precision efficacy. Neuroinflammation has been increasingly recognized as a critical factor in pathogenesis various NDs, especially Alzheimer's disease (AD). In this study, novel membrane coating is designed...
Adenosine is a key endogenous signaling molecule that regulates immune responses. A(2B) adenosine receptor (AR) relatively low-affinity for adenosine, and the activation of A(2B)AR believed to require pathological level associated with ischemia, inflammation, trauma, or other types stress. The role in pathogenesis multiple sclerosis (MS) still unclear. In this study, we discovered was upregulated both peripheral blood leukocytes MS patients lymphoid tissues experimental autoimmune...
Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism caused by ATP7B pathogenic mutations. The symptoms WD can be effectively prevented if the affected individuals are identified and intervened early. However, clinical utility this molecular analysis challenging due to hundreds variants with various effects in gene. Here, we aim describe spectrum assess their Han Chinese population.The gene was directly sequenced 632 unrelated patients 503 healthy individuals. were...
Huntington's disease (HD) represents an important model for neurodegenerative disorders and proteinopathies. It is mainly caused by cytotoxicity of the mutant huntingtin protein (Htt) with expanded polyQ stretch. While Htt ubiquitously expressed, HD characterized selective neurodegeneration striatum. Here we report a striatal-enriched orphan G protein-coupled receptor(GPCR) Gpr52 as stabilizer in vitro vivo. modulates via cAMP-dependent but PKA independent mechanisms. located within intron...
Prefrontal cortical PV INs and SST differentially regulate low gamma rhythms social interaction behavior.
Based on the logistics performance index proposed by World Bank, this study uses entropy method to construct green and empirically analyzes impact of Regional Comprehensive Economic Partnership (RCEP) countries China’s export trade using expanded gravity model. The results show that RCEP can significantly promote countries, various measures improve have different impacts trade. order influence degree is efficiency a customs clearance procedure, convenience arranging freight with competitive...
Magnitude and diversity of gut microbiota metabolic systems are critical in shaping human health diseases, but it remains largely unclear how complex metabolites may selectively regulate determine diseases. Here, we show that failures or compromised effects anti-TNF-α therapy inflammatory bowel diseases (IBD) patients were correlated with intestinal dysbacteriosis more pro-inflammatory bacteria, extensive unresolved inflammation, failed mucosal repairment, aberrant lipid metabolism,...
Abstract Accurate differential diagnosis among various dementias is crucial for effective treatment of Alzheimer’s disease (AD). The study began with searching novel blood-based neuronal extracellular vesicles (EVs) that are more enriched in the brain regions vulnerable to AD development and progression. With extensive proteomic profiling, GABRD GPR162 were identified as regionally plasma EVs markers. performance GPR162, along molecule pTau217, was tested using self-developed optimized...