A5100639697- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Chemokine receptors and signaling
- Neuroscience and Neuropharmacology Research
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Immunotherapy and Immune Responses
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Immune Cell Function and Interaction
- High Altitude and Hypoxia
- Genetics and Physical Performance
- Atherosclerosis and Cardiovascular Diseases
- Muscle Physiology and Disorders
- Cytokine Signaling Pathways and Interactions
- Renal Diseases and Glomerulopathies
Hangzhou First People's Hospital
2021-2025
Westlake University
2023-2025
Hangzhou Medical College
2018-2025
Zhejiang Provincial People's Hospital
2018-2025
Beijing Chao-Yang Hospital
2013-2024
Capital Medical University
2013-2024
Southern Medical University
2023-2024
Beijing Sport University
2011-2024
General Administration of Sport of China
2024
Medical University of South Carolina
2012-2024
CD4+ regulatory T (Treg) cells have a profound ability to suppress host immune responses, yet little is understood about how these are regulated. We describe mechanism linking Toll-like receptor (TLR) 8 signaling the control of Treg cell function, in which synthetic and natural ligands for human TLR8 can reverse function. This effect was independent dendritic but required functional TLR8-MyD88-IRAK4 cells. Adoptive transfer ligand-stimulated into tumor-bearing mice enhanced anti-tumor...
Hepatitis C infection causes a state of chronic oxidative stress, which may contribute to fibrosis and carcinogenesis in the liver. Previous studies have shown that expression HCV core protein hepatoma cells depolarized mitochondria increased reactive oxygen species (ROS) production, but mechanisms these effects are unknown. In this study we examined properties liver from transgenic mice expressing protein, normal incubated with recombinant protein. Liver proteins core, E1 E2 demonstrated...
Hepatocellular carcinoma (HCC) is one of the paramount causes cancer-related death worldwide. Despite recent advances have been made in clinical treatments HCC, general prognosis patients remains poor. Therefore, it imperative to develop a less toxic and more effective therapeutic strategy. Currently, series cellular, molecular, pharmacological experimental approaches were utilized address unrecognized characteristics disulfiram (DSF), pursuing goal repurposing DSF for cancer therapy. We...
Interactions with the immune system may lead tumorigenic cells into dormancy. However, underlying molecular mechanism is poorly understood. Using a 3D fibrin gel model, we show that IFN-γ induces tumour-repopulating (TRCs) to enter dormancy through an indolamine 2,3-dioxygenase 1 (IDO1)-kynurenine (Kyn)-aryl hydrocarbon receptor (AhR)-p27 dependent pathway. Mechanistically, signalling triggers differentiated tumour cell apoptosis via STAT1; however, when IDO1 and AhR are highly expressed as...
Ferroptosis is a newly discovered form of non-apoptotic regulated cell death and characterized by iron-dependent lipid peroxidation. Due to the enhanced dependence on iron in cancer cells, induction ferroptosis becoming promising therapeutic strategy. However, precise underlying molecular mechanism regulation process remains largely unknown. In present study, we demonstrate that protein Frataxin (FXN) key regulator modulating homeostasis mitochondrial function. Suppression FXN expression...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is an extremely lethal cancer with limited treatment options. Cisplatin (DDP) used as a mainstay of chemotherapeutic agents in combination other drugs or radiotherapy for PDAC therapy. However, DDP exhibits severe side-effects that can lead to discontinuation therapy, and the acquired drug resistance tumor cells presents serious clinical obstacles. Therefore, it imperative develop more effective less toxic therapeutic strategy. We others have...
Abstract Breast tumor cells express the chemokine receptor CXCR3, which binds ligands CXCL9, CXCL10, and CXCL11. CXCR3 other receptors may mediate metastasis by supporting migration of to sites ligand expression including lymph nodes, lungs, bone marrow. We examined relationship clinical outcome in 75 women diagnosed with early-stage breast cancer. detected malignant epithelium from all tumors. Twelve percent were weakly positive 64% had moderate levels CXCR3. Strong CXCR3-positive staining...
Ferroptosis is a newly identified type of programmed cell death, which preferentially targets iron-rich cancer cells such as hepatocellular carcinoma (HCC). Ferritin heavy chain (FTH) major iron storing nanocage to store redox-inactive iron, and harbors ferroxidase activity prevent the iron-mediated production ROS. Our previous studies have demonstrated that FTH acts protective role increase cellular resistance ferroptosis. However, specific in development HCC ferroptosis remains unclear.The...
Abstract Ferroptosis, a new form of programmed cell death, not only promotes the pathological process various human diseases, but also regulates cancer progression. Current perspectives on underlying mechanisms remain largely unknown. Herein, we report member NEET protein family, CISD3, exerts regulatory role in progression and ferroptosis both vivo vitro. Pan-cancer analysis from TCGA reveals that expression CISD3 is generally elevated cancers which are consequently associated with higher...
Hepatocellular carcinoma (HCC) is one of the most prevalent malignant tumors and fourth leading cause cancer-related death globally, which characterized by complicated pathophysiology, high recurrence rate, poor prognosis. Our previous study has demonstrated that disulfiram (DSF)/Cu could be repurposed for treatment HCC inducing ferroptosis. However, effectiveness DSF/Cu may compromised compensatory mechanisms weaken its sensitivity. The underlying these responses are currently unknown....
Bacteria-infected skin wounds caused by external injuries remain a serious challenge to the whole society. Wound healing dressings, with excellent antibacterial activities and potent regeneration capability, are increasingly needed clinically. Here, we reported novel functional microneedle (MN) array comprising methacrylated hyaluronic acid (MeHA) embedded pH-responsive functionalized zeolitic imidazolate framework-8 (ZIF-8) nanoparticles treat bacteria-infected cutaneous wounds....
Diffuse large B-cell lymphoma (DLBCL), a heterogeneous lymphoid malignancy, poses significant threat to human health. The standard therapeutic regimen for patients with DLBCL is rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP), typical cure rate of 50–70%. However, some either relapse after complete remission (CR) or exhibit resistance R-CHOP treatment. Therefore, novel approaches are imperative managing high-risk refractory DLBCL. Ferroptosis driven by...
Abstract Reactive oxygen species (ROS) serve as typical metabolic byproducts of aerobic life and play a pivotal role in redox reactions signal transduction pathways. Contingent upon their concentration, ROS production not only initiates or stimulates tumorigenesis but also causes oxidative stress (OS) triggers cellular apoptosis. Mounting literature supports the view that are closely interwoven with pathogenesis cluster diseases, particularly those involving cell proliferation...
Acute myeloid leukemia (AML) is a prevalent hematological malignancy that exhibits wide array of molecular abnormalities. Although traditional treatment modalities such as chemotherapy and allogeneic stem cell transplantation (HSCT) have become standard therapeutic approaches, considerable number patients continue to face relapse encounter bleak prognosis. The emergence immune escape, immunosuppression, minimal residual disease (MRD), other contributing factors collectively contribute this...
Matrix metalloproteinases (MMPs) play a key role in periodontal disease. Although it is known that macrophages and fibroblasts are co-localized express MMPs the diseased tissue, effect of interaction between these two cell types on MMP expression has not been well elucidated. Furthermore although diabetes associated with accelerated tissue destruction, remains unknown whether hyperglycemia, major metabolic abnormality diabetes, regulates by affecting cross-talking macrophages. In this study,...