A5048687484- Electrospun Nanofibers in Biomedical Applications
- Tissue Engineering and Regenerative Medicine
- Silk-based biomaterials and applications
- Wound Healing and Treatments
- Extracellular vesicles in disease
- Advancements in Transdermal Drug Delivery
- Aortic Disease and Treatment Approaches
- Proteoglycans and glycosaminoglycans research
- Pain Mechanisms and Treatments
- Nanoparticles: synthesis and applications
- Antimicrobial Peptides and Activities
- Nitric Oxide and Endothelin Effects
- Cardiac Ischemia and Reperfusion
- Connective tissue disorders research
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
State Key Laboratory of Medicinal Chemical Biology
2018-2022
Nankai University
2015-2022
Collaborative Innovation Center of Chemical Science and Engineering Tianjin
2015
Bacteria-infected skin wounds caused by external injuries remain a serious challenge to the whole society. Wound healing dressings, with excellent antibacterial activities and potent regeneration capability, are increasingly needed clinically. Here, we reported novel functional microneedle (MN) array comprising methacrylated hyaluronic acid (MeHA) embedded pH-responsive functionalized zeolitic imidazolate framework-8 (ZIF-8) nanoparticles treat bacteria-infected cutaneous wounds....
Vascular bypass surgery continues to use autologous grafts and often suffers from a shortage of donor grafts. Decellularized xenografts derived porcine veins provide promising candidate because their abundant availability low immunogenicity. Unfortunately, transplantation outcomes are far satisfactory insufficient regeneration adverse pathologic remodeling. Herein, nitrate-functionalized prosthesis has been incorporated into decellularized vein graft fabricate bio-hybrid vascular with local...
Abstract There is a great need for small diameter vascular grafts among patients with cardiovascular diseases annually. However, continuous foreign body reactions and fibrosis capsules brought by biomaterials are both prone to poor tissue regeneration. To address this problem, we fabricated polycaprolactone (PCL) graft incorporated quercetin (PCL/QCT graft) in study. In vitro cell assay showed that reduced the expressions of pro-inflammatory genes macrophages while increased...
Here, we present a protocol to fabricate macroporous PCL vascular graft and describe an evaluation by using rat model of abdominal aorta replacement.The electrospun grafts often possess relatively small pores, which limit cell infiltration into the hinder regeneration remodeling neo-arteries.In this study, with thicker fibers (5 -6 µm) larger pores (~30 were fabricated modified processing technique.The long-term performance was evaluated implantation in model.Ultrasound analysis showed that...
Vascular graft has proven to be an effective strategy for the treatment of cardiovascular diseases. However grafts made solely from synthetic polymers cannot satisfy clinic requirements in terms low long-term patency, because they only provide a simple structural or physical replacement without biological functions. In order address issue, we aim fabricate vascular which could mimic native extracellular matrix (ECM) both physiological structure and bio-functions. Different types strategies...