A5048305253- Ovarian cancer diagnosis and treatment
- Chemokine receptors and signaling
- Environmental law and policy
- Endometrial and Cervical Cancer Treatments
- Property Rights and Legal Doctrine
- American Environmental and Regional History
- Estrogen and related hormone effects
- Cancer Mechanisms and Therapy
- Reproductive System and Pregnancy
- Peptidase Inhibition and Analysis
- Legal Systems and Judicial Processes
- Protease and Inhibitor Mechanisms
- Endometriosis Research and Treatment
- BRCA gene mutations in cancer
- Cervical Cancer and HPV Research
- Intraperitoneal and Appendiceal Malignancies
- SARS-CoV-2 and COVID-19 Research
- Uterine Myomas and Treatments
- Urinary and Genital Oncology Studies
- Bacterial Identification and Susceptibility Testing
- Breast Lesions and Carcinomas
- Environmental Justice and Health Disparities
- Lymphoma Diagnosis and Treatment
- International Maritime Law Issues
- Cytokine Signaling Pathways and Interactions
Cornell University
2016-2024
New York Hospital Queens
2014-2024
University of Maryland, Baltimore
2006-2023
Lenox Hill Hospital
2009-2023
U-M Rogel Cancer Center
2007-2023
University of California, Los Angeles
2021-2023
Peking Union Medical College Hospital
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Suzhou Institute of Systems Medicine
2023
Kaiser Permanente
2023
Matrix metalloproteinases are a highly regulated family of enzymes, that together can degrade most components the extracellular matrix. These proteins active in normal and pathological processes involving tissue remodeling; however, their sites synthesis specific roles poorly understood. Using situ hybridization, we determined cellular distributions matrix inhibitor metalloproteinase-1, an metalloproteinases, endometrium during reproductive cycle. The mRNAs for all were detected menstrual...
Matrix metalloproteinases of the stromelysin family are expressed in human endometrium as a consequence cellular events during menstrual cycle that require extracellular matrix remodeling. We have recently documented presence these enzymes lesions endometriosis, benign disease presents persistent ectopic sites endometrial tissue, usually within peritoneal cavity. Endometriosis can develop after retrograde menstruation tissue fragments, and establishment cavity requires breakdown matrix. To...
Abstract The metalloproteinase matrilysin is widely expressed in the epithelial tumor cells of malignant colorectal adenocarcinomas. Approximately 50% benign adenomas also express low levels that focally localized. expression stromelysin‐1, stromelysin‐3, and gelatinase A was observed stromal component several carcinomas not present adenomatous tissue. interstitial collage‐nase B occasional carcinomas. Stromelysin‐2 transcripts were detectable any samples examined. Tissue inhibitor...
Unlike most normal adult tissues, cyclic growth and tissue remodeling occur within the uterine endometrium throughout reproductive years. The matrix metalloproteinases (MMPs), a family of structurally related enzymes that degrade specific components extracellular are thought to be physiologically relevant mediators composition turnover. Our laboratory has identified MMPs stromelysin in cycling human endometrium, implicating these mediating extensive occurs this tissue. While stromelysins...
The hallmark of the menstrual cycle is extensive steroid-dependent tissue turnover. Estrogen mediates endometrial cell growth and structural remodeling, whereas progesterone suppresses estrogen-dependent proliferation promotes cellular differentiation. In nonfertile cycles, degradation menstruation occur as a consequence steroidal deprivation ovarian corpus luteum fails. Stromal-epithelial interactions are recognized necessary component in mediating steroid-induced Specific mRNAs for...
Myeloid sarcoma (MS) is a neoplasm of immature granulocytes, monocytes, or both involving any extramedullary site. The correct diagnosis MS important for adequate therapy, which often delayed because high misdiagnosis rate. To evaluate the lineage differentiation neoplastic cells in by immunohistochemistry, and to correlate results with clinicopathologic findings cytogenetic studies. Histologic immunohistochemical examinations were performed on formalin-fixed paraffin-embedded tissue samples...
Abstract Breast tumor cells express the chemokine receptor CXCR3, which binds ligands CXCL9, CXCL10, and CXCL11. CXCR3 other receptors may mediate metastasis by supporting migration of to sites ligand expression including lymph nodes, lungs, bone marrow. We examined relationship clinical outcome in 75 women diagnosed with early-stage breast cancer. detected malignant epithelium from all tumors. Twelve percent were weakly positive 64% had moderate levels CXCR3. Strong CXCR3-positive staining...
This report describes the results of transvaginal color Doppler sonography (TV-CDS) 43 surgically proved ovarian masses. Waveform analyses signals arising from specific vessels (i.e., peripheral, central, septal) adjacent to and within these masses were correlated those seen on macroscopic pathologic evaluation. The mean standard deviation pulsatility indices (PI) 32 benign lesions (1.8 +/- 0.8) higher than 11 malignant ones (0.8 0.6) (P = 0.03). However, range (4.0 0.7) (1.5 0.4) did...
Determination of the mitotic index in sections endometrium stained with haematoxylin and eosin (H&E) is difficult time-consuming. We assessed value two markers as immunocytochemical reagents for measuring rates endometrium.Mitotic protein monoclonal antibody 2 (MPM-2) anti-phosphorylated histone H3 (Phospho H3) were applied to paraffin rhesus macaque human endometrium.In estrogen-treated mean +/- SEM indices were: H&E 1.5 0.25%, Phospho 1.02 0.23% MPM-2 0.69 0.17%; these not statistically...
This study analyzed vessel location, maximum systolic velocity, impedance, and waveform shape in 25 benign malignant surgically excised pathologically examined ovarian masses as depicted by transvaginal or transabdominal color Doppler sonography, both. Those parameters that achieved statistical significance (P > 0.05) between the two types of included shape. Malignant typically were characterized centrally located vessels had low impedance without a diastolic "notch" waveform. Maximum...
Abstract Purpose: Analysis of molecular genetic markers in biological fluids has been proposed as a powerful tool for cancer diagnosis. We have characterized detail the signatures primary non–small cell lung cancer, which provided potential diagnostic biomarkers cancer. The aim this study was to determine whether changes can be used sputum specimen early detection Experimental Design: Genetic aberrations genes HYAL2, FHIT, and SFTPC were evaluated paired tumors samples from 38 patients with...
Endoscopic ultrasound‐guided fine‐needle aspiration (EUS‐FNA) of the pancreas is an efficient and minimally invasive procedure for diagnosis staging pancreatic adenocarcinoma. Because some limitations EUS‐FNA in well‐differentiated or early stage cancers, purpose this study to assess added benefit immunohistochemistry. We studied five proteins overexpressed adenocarcinoma, namely, prostate stem cell antigen, fascin, 14‐3‐3 sigma, mesothelin S100P utilizing immunohistochemistry on paraffin...
Fanconi anemia is an inherited cancer predisposition disease characterized by cytogenetic and cellular hypersensitivity to cross-linking agents. Seeking evidence of protein dysfunction in women at risk ovarian cancer, we screened surface epithelial cells from 25 primary cultures established 22 patients using cross-linker assays. Samples were obtained (a) high for with histologically normal ovaries, (b) patients, (c) a control group no family history breast or cancer. In chromosomal breakage...