A5103171255- Immune Cell Function and Interaction
- Hematopoietic Stem Cell Transplantation
- T-cell and B-cell Immunology
- Cytomegalovirus and herpesvirus research
- Pancreatic and Hepatic Oncology Research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Lymphoma Diagnosis and Treatment
- Chemokine receptors and signaling
- Immune cells in cancer
- Cancer Risks and Factors
- Chronic Lymphocytic Leukemia Research
- Geological and Geochemical Analysis
- earthquake and tectonic studies
- Neutropenia and Cancer Infections
- Natural product bioactivities and synthesis
- Single-cell and spatial transcriptomics
- Inflammatory Biomarkers in Disease Prognosis
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Biocrusts and Microbial Ecology
- Viral-associated cancers and disorders
- Microfluidic and Bio-sensing Technologies
- Reproductive System and Pregnancy
- Pharmacological Effects of Natural Compounds
First Affiliated Hospital of Xiamen University
2022-2024
Xiamen University
2022-2024
Ludong University
2021-2024
Peking University
2016-2023
Peking University People's Hospital
2016-2023
Fujian Medical University
2019-2023
Center for Life Sciences
2017-2022
Zhejiang Provincial People's Hospital
2018-2022
Hangzhou Medical College
2018-2022
King University
2022
Abstract Background Human pancreatic ductal adenocarcinoma (PDAC) responds poorly to immune checkpoint inhibitor (ICPi). While the mechanism is not completely clear, it has been recognized that tumor microenvironment (TME) plays key roles. We investigated if targeting CD47 with a monoclonal antibody could enhance response of PDAC ICPi by altering TME. Methods Using immunohistochemistry, we examined tumor-infiltrating CD68 + pan-macrophages (CD68 M) and CD163 M2 macrophages (CD163 M2)...
Introduction Despite accumulated evidence in T-cell exhaustion acute myeloid leukemia (AML), the immunotherapeutic targeting exhausted T cells such as programmed cell death protein 1 (PD-1) blockade AML failed to achieve satisfying efficacy. Characteristics of remained be explored. Methods Phenotypic analysis bone marrow (BM) using flow cytometry combining senescent and markers was performed de novo patients healthy donors well with complete remission (CR). Functional subsets also cytometry....
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm. Tyrosine kinase inhibitors (TKIs) are commonly used to treat CML; however, drug resistance of CML cells TKIs has limited their clinical application. Shikonin, traditional Chinese herb, long been in China, but the roles and related molecular mechanisms shikonin treatment remain unclear. Here, we aimed evaluate effects on proliferation, apoptosis, migration K562 cells, cell line.Firstly, proliferation apoptosis were tested by...
Abstract Radiofrequency ablation (RFA) is an effective local therapy approach for treating solitary tumor of many types malignancy. The impact RFA on the immune microenvironment distant tumors after treatment still unclear. In this study, by using syngeneic models and single-cell RNA T-cell receptor sequencing, we have investigated alterations tumor-infiltrating cells in non-RFA tumors. Single-cell sequencing identified six distinct lymphoid clusters, five monocyte/macrophage three dendritic...
Background Adoptive NK cell infusion is a promising immunotherapy for acute myeloid leukemia (AML) patients. The aim of this study was to test the activity clinical‐grade membrane‐bound IL‐21/4‐1BBL‐expanded products against AML in vivo. Methods Fresh peripheral blood mononuclear cells (PBMCs) were incubated with equal numbers irradiated IL‐21/4‐1BBL‐expressing K562 2–3 weeks induce expansion. Results Expansion 2 and 3 produced ∼4 8 × 10 9 from 7 PBMCs. production CD107a TNF‐α response lines...
Human cytomegalovirus (HCMV) infection, especially persistent HCMV is an important cause of morbidity and mortality after allogenic stem cell transplantation (allo-SCT). Antiviral agents remain the first-line therapy but are limited by side effects acquired resistance.We evaluated safety efficacy donor-derived HCMV-specific cytotoxic T cells (CTLs) as a for infection allo-SCT investigated underlying mechanisms.In humanized HCMV-infected mice, with CTLs effectively combated systemic promoting...
Abstract The rate and extent of natural killer (NK)–cell education after hematopoietic cell transplantation correlates with leukemia control. To study the effect donor host HLA on NK-cell reconstitution, single killer-cell immunoglobulin-like receptor (KIR)+ NK cells (exhibiting KIR2DL1, KIR2DL2/KIR2DL3, or KIR3DL1 as their sole receptor) were grouped into 4 groups based interaction between donor/host inhibitory KIR in 2 cohorts (n = 114 n 276, respectively). On days 90 to 180...
Abstract The Altun–Qilian–North Qaidam (AQQ) orogenic system in northern Tibet is considered to be the northernmost collage of Prototethyan domain. It regarded as resulting from collisions between various continental terranes derived margin Gondwana, although AQQ also includes abundant ophiolites, arc magmatic rocks and subduction–accretion complexes. Some researchers regard north a typical accretionary orogen built by development an evolving arc–accretion complex growing southwards along...
CMV infection remains an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Several investigators have reported that adaptive NKG2C+ NK cells persistently expand during reactivation. In our study, 2 cohorts were enrolled to explore the relationships among NKG2C genotype, reconstitution, infection. Multivariate analysis showed donor gene deletion was independent prognostic factor for reactivation refractory Furthermore, cells'...
Summary Licensed natural killer ( NK ) cells have been demonstrated to anti‐cytomegalovirus CMV activity. We prospectively analysed the human leucocyte antigen typing of donor‐recipient pairs and cell immunoglobulin–like receptor KIR donors for 180 leukaemia patients assess predictive roles licensed on reactivation post‐T‐cell‐replete haploidentical stem transplantation. Multivariate analysis showed that ligand graft‐versus‐host or host‐versus‐graft direction mismatch was associated with...
<h2>Abstract</h2> The immune mechanism underlying graft-versus-host disease (GVHD) after allogeneic stem cell transplantation (HSCT) remains unclear. Natural killer (NK) cells play a crucial role in mediating pathogen-specific immunity and are the first donor-derived lymphocytes reconstituted post-HSCT. However, NK vary at different stages HSCT. Here, we found that absolute NKG2A<sup>+</sup> subset counts percentages of among were significantly reduced GVHD patients HSCT compared with those...
BACKGROUND Estrogen is involved in both bone metabolism and breast cancer proliferation. However, evidence about the risk of according to women's mineral density (BMD) scarce, little known their causal associations. METHODS Women participating UK Biobank cohort were used investigate association between BMD using Cox regression models. Instrumental variants associated with estimated (eBMD) extracted from genome‐wide studies European ancestry. Logistic was calculate genetic 2‐sample Mendelian...
Background: Despite the potential role of several chemokines in migration cytotoxic immune cells to prohibit breast cancer cell proliferation, a comprehensive view and risk prognosis is scarce, little known about their causal associations. Methods: With two-sample Mendelian randomization (MR) approach, genetic instruments associated with 30 plasma were created. Their associations its survival by molecular subtypes extracted from recent genome-wide association study 133,384 cases 113,789...
Breast cancer is the most common and leading cause of cancer-related death among women. However, evidence concerning hematological biochemical markers influencing natural history breast from in situ to mortality limited.
Abstract Background Most of acute pancreatitis (AP) are mild and self‐limiting, however, 15%–20% patients develop severe (SAP) or moderately (MSAP) with local systemic complications. Infection complications (ICs) result in 40%–70% morbidity high mortality rates among SAP MSAP patients. It is more important to early recognize ICs SAP. Several studies have indicated that serum soluble programmed cell death protein (sPD‐1) 1 ligand (sPD‐L1) levels were higher sepsis than healthy volunteers a...
Abstract Granulocyte colony‐stimulating factor (G‐ CSF ) has been widely used in the field of allogeneic haematopoietic stem cell transplantation (allo‐ HSCT for priming donor cells from bone marrow ( BM to peripheral blood PB collect more conveniently. Donor‐derived natural killer NK have important antitumour functions and immune regulatory roles post‐allo‐ . The aim this study was evaluate effect G‐ on donors' percentage among nuclear lymphocyte significantly decreased led increased ratio...
Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of lymphoma, accounting for approximately 30% to 40% non-Hodgkin's lymphomas (NHL). The administration rituximab significantly improved outcomes DLBCL; however, unavoidable development resistance limits long-term efficacy. Therefore, a new generation less toxic drugs with higher chemotherapy response required prevent or reverse chemoresistance. TEOA pentacyclic triterpenoid compound isolated from roots Actinidia eriantha....