Lingling Xu

ORCID: 0000-0002-0142-0053
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About
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Research Areas
  • Plant Pathogens and Fungal Diseases
  • Plant Taxonomy and Phylogenetics
  • Mycorrhizal Fungi and Plant Interactions
  • Hematopoietic Stem Cell Transplantation
  • Atmospheric chemistry and aerosols
  • Traditional Chinese Medicine Studies
  • Immune Cell Function and Interaction
  • MicroRNA in disease regulation
  • Nematode management and characterization studies
  • Cancer-related molecular mechanisms research
  • Plant Reproductive Biology
  • T-cell and B-cell Immunology
  • Atmospheric Ozone and Climate
  • Acupuncture Treatment Research Studies
  • Mycotoxins in Agriculture and Food
  • Plant tissue culture and regeneration
  • Liver Disease Diagnosis and Treatment
  • Fungal Biology and Applications
  • Advancements in Transdermal Drug Delivery
  • Ecology and Conservation Studies
  • Healthcare and Venom Research
  • Lung Cancer Treatments and Mutations
  • Odor and Emission Control Technologies
  • Psoriasis: Treatment and Pathogenesis
  • Nanoplatforms for cancer theranostics

Peking University
2010-2025

Shandong Provincial QianFoShan Hospital
2021-2024

Anhui Medical University
2010-2024

Shandong First Medical University
2021-2024

Institute of Grassland Research
2023-2024

Lanzhou University
2023-2024

Ministry of Agriculture and Rural Affairs
2023-2024

State Forestry and Grassland Administration
2023-2024

Chinese Academy of Forestry
2023-2024

First Affiliated Hospital Zhejiang University
2023-2024

Chronic nonhealing diabetic wounds are becoming increasingly severe, with high rates of mortality and disability, owing to the difficulty in wound healing caused by hyperglycemia, blocked angiogenesis, biofilm infection, excessive oxidative stress. A multicomponent enzyme-responsive natural polymer, a hyaluronic acid (HA) microneedle, embedded cerium/zinc-based nanomaterial (ZCO) for treatment is reported. ZCO-HA can destroy oxidation balance bacteria, kill scavenge reactive oxygen species...

10.1002/adhm.202300725 article EN Advanced Healthcare Materials 2023-04-22

Abstract. Peroxyacetyl nitrate (PAN), a key indicator of photochemical pollution, is generated similarly to ozone (O3), through reactions involving specific volatile organic compounds (VOCs) and nitrogen oxides. Notably, PAN has been observed at unexpectedly high concentrations (maximum: 3.04 ppb) during the summertime. The average daily values show strong correlation with black carbon (BC) (R = 0.77) O3 0.77), suggesting close connection between summertime haze pollution. We addressed...

10.5194/acp-25-905-2025 article EN cc-by Atmospheric chemistry and physics 2025-01-23

Carnivorism is one of the basic life strategies fungi. Carnivorous fungi possess ability to trap and digest their preys by sophisticated trapping devices. However, origin development fungal carnivorism remains a gap in evolution biology. In this study, five protein-encoding genes were used construct phylogeny carnivorous phylum Ascomycota; these prey on nematodes means specialized structures such as constricting rings adhesive traps. Our analysis revealed definitive pattern evolutionary for...

10.1073/pnas.1120915109 article EN Proceedings of the National Academy of Sciences 2012-06-19

Ophiocordyceps sinensis (syn. Cordyceps sinensis), endemic to alpine regions on the Tibetan plateau, is one of most valuable medicinal fungi in world. Huge commercial demand has led excessive harvest and a dramatic decline its numbers. The diversity terrains climates Plateau broad insect host range (more than 50 species family Hepialidae) may have resulted substantial intraspecific genetic for this fungus. objective study was evaluate population distribution O. from geographically diverse...

10.1186/1471-2148-9-290 article EN cc-by BMC Evolutionary Biology 2009-12-01

Chronic hepatitis B (CHB) is caused by HBV infection and affects the lives of millions people worldwide causing liver inflammation, cirrhosis, cancer. Interferon-alpha (IFN-α) therapy a conventional immunotherapy that has been widely used in CHB treatment achieved promising therapeutic outcomes activating viral sensors interferon-stimulated genes (ISGs) suppressed HBV. However, longitudinal landscape immune cells patients effect IFN-α on system are not fully understood.

10.1097/hep.0000000000000524 article EN Hepatology 2023-06-27

Schematic illustration of the structure and drug release process a responsive cascade delivery scaffold (RCDDS) for peripheral nerve injury repair.

10.1039/d3mh01511d article EN cc-by-nc Materials Horizons 2023-11-30

The black morel Morchella sextelata (Morchellaceae, Pezizales) is a valuable edible mushroom that can be cultivated on large scale, but severe yield decline observed during continuous cropping. effect of long-term cropping soil-borne diseases and the dysbiosis microbiome how these biotic factors affect are not well understood. To help fill this knowledge gap, we designed an indoor experiment to investigate influence regimes soil physicochemical properties, richness distribution fungal...

10.3390/jof9040492 article EN cc-by Journal of Fungi 2023-04-20

Pacific sardine (Sardinops sagax) is a commercially important species and supports fisheries in the Northwest Ocean (NPO). Understanding habitat distribution patterns of great significance for fishing ground prediction stock management. In this study, both single-algorithm ensemble models were established through Biomod2 package by combining occurrence data, sea surface temperature (SST), height (SSH), salinity (SSS) chlorophyll-a concentration (Chla) NPO during main season (June–November)...

10.3390/fishes8020086 article EN cc-by Fishes 2023-01-31

Abstract Advancements in medical education have consistently been underpinned by corresponding progress technology. With the ever-changing landscape of technology and healthcare, simulation has become an integral component healthcare delivery process. Research indicates that fosters active learning opportunities enhances student engagement nursing education. This paper explores evolution through lens technological innovation its application. There are a variety options available to clinical...

10.1097/nr9.0000000000000085 article EN cc-by-nc-nd Interdisciplinary Nursing Research 2025-03-06

The aim of this study was to investigate the effects IL-17-producing T cells, including Th17 and Tc17 on acute graft-versus-host disease (aGVHD) in patients who had undergone granulocyte colony-stimulating factor (G-CSF)-mobilised peripheral blood progenitor cell (PBPC) G-CSF-primed bone marrow (G-BM) transplantation. Allografts from forty-one were analysed for cells with respect aGVHD. Furthermore, ten aGVHD onset monitored presence by flow cytometry. Patients received a higher dose G-BM...

10.1002/eji.201040793 article EN European Journal of Immunology 2011-01-03

Abstract NF-κB signaling regulates diverse processes such as cell death, inflammation, immunity, and cancer. The activity of is controlled by methionine 1-linked linear polyubiquitin, which assembled the ubiquitin chain assembly complex (LUBAC) ubiquitin-conjugating enzyme UBE2L3. Recent studies found that deubiquitinase OTULIN breaks chain, thus inhibiting signaling. Despite essential role in has been established, regulatory mechanism for not well elucidated. To discover potential...

10.1093/jmcb/mjz081 article EN cc-by-nc Journal of Molecular Cell Biology 2019-07-10

Motor dysfunction is common in patients with stroke. Acupuncture has become an acceptable alternative method for stroke rehabilitation. Previous studies have shown various functional connectivity changes activated by acupuncture. We introduced intersubject correlation (ISC) and (ISFC) analyses into the magnetic resonance imaging (fMRI) ischemic to seek a activation suppression pattern triggered In this study, 63 motor 42 normal controls were analyzed. Three scans conducted during resting...

10.3389/fneur.2022.900520 article EN cc-by Frontiers in Neurology 2022-06-06

Neuroimaging studies have confirmed that acupuncture can promote static functional reorganization in poststroke patients with motor dysfunction. But its effect on dynamic brain networks remains unclear. This study is aimed at investigating how affected the brain's network connectivity (dFNC) after ischemic stroke. We conducted a single-center, randomised controlled neuroimaging stroke patients. A total of 53 were randomly divided into true acupoint treatment group (TATG) and sham (SATG)...

10.1155/2023/8510213 article EN cc-by Neural Plasticity 2023-06-20

Topical therapy has received worldwide attention for in situ tumors owing to its higher efficacy of drug delivery. Herein, this work reports a dissolvable multifunctional hyaluronic acid microneedles (HMNs) patch coloaded with temozolomide (TMZ) and MnCl

10.1002/adhm.202303215 article EN Advanced Healthcare Materials 2023-12-19

Two types of bifunctional amido-ether ligands (syn-L and anti-L) with the rigid anthracene skeleton were designed to support dinuclear group 4 metal complexes. All organic organometallic complexes (syn-M2 anti-M2; M = Hf, Zr, Ti) fully characterized by 1H 13C NMR spectroscopies elemental analyses. The anti-Hf2 complex showed two confirmations at room temperature C2-symmetry or S2-symmetry that can inter-exchange, as indicated VT NMR, while only a C2-symmetric isomer was observed for syn-Hf2...

10.1021/acs.inorgchem.2c04211 article EN Inorganic Chemistry 2023-01-31
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