A5101642986- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Inflammasome and immune disorders
- Pharmacological Effects of Natural Compounds
- Colorectal Cancer Treatments and Studies
- Malaria Research and Control
- Pancreatic and Hepatic Oncology Research
- Tannin, Tannase and Anticancer Activities
- Peptidase Inhibition and Analysis
- Neuroblastoma Research and Treatments
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
- Brain Metastases and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Garlic and Onion Studies
- Neuroendocrine Tumor Research Advances
- Nutrition and Health in Aging
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Bone health and treatments
- Clinical Nutrition and Gastroenterology
- Renal cell carcinoma treatment
- RNA regulation and disease
Second Affiliated Hospital of Dalian Medical University
2019-2025
Hebei North University
2021-2025
Dalian Medical University
2019-2024
Capital Medical University
2023
Fourth Affiliated Hospital of Guangxi Medical University
2019
Hubei Cancer Hospital
2018
Colorectal cancer (CRC) is a common malignant tumor worldwide. Approximately 20%-25% of patients have metastases at the time initial diagnosis, and nearly half eventually develop metastatic cancer. The standard first- second-line treatments for unresectable CRC are full-dose two-/three-agent chemotherapy with or without combination molecularly targeted agents. However, many ineligible intensive therapy due to poor performance status advanced age. TAS-102 (trifluridine/tipiracil) in...
<title>Abstract</title> The full text of this preprint has been withdrawn by the authors due to necessary revisions in study endpoints and methodology ensure alignment with current clinical research standards. Therefore, do not wish work be cited as a reference. Questions should directed corresponding author.
Neuroinflammation and neuronal apoptosis are considered as the critical factors in pathogenesis of multiple neurological diseases. Recent studies have shown that long non-coding RNA (lncRNA) plays a crucial part neuroinflammation apoptosis.The expression levels lncRNA KCNQ1OT1, miR-30e-3p NLRP3 lipopolysaccharide (LPS)-induced HMC3 cells were analyzed using RT-qPCR. MTT assay, LDH release assay ELISA used to assess effect KCNQ1OT1 on apoptosis. The targeted regulatory relationships among...
Abstract Background Tissue factor pathway inhibitor 2 (TFPI2) participates in carcinogenesis of various tumors, and is associated with poor survival breast cancer patients. However, the effect underlying mechanism TFPI2 on progression remains to be investigated. Methods The expression level tissues cell lines was examined via qRT-PCR (quantitative real-time polymerase chain reaction) immunohistochemistry. CCK8 (Cell Counting Kit-8), colony formation, wound healing or transwell assays were...
FOLFIRINOX chemotherapy displays significant survival improvements in patients with pancreatic cancer. However, toxicities have hampered enthusiasm for the use of full dose. In order to increase tolerability, many researchers focused on modification FOLFIRINOX. On other hand, hyperthermia (HT) has been considered as an effective ancillary treatment cancer therapy. Up now, there is no report evaluating combining deep regional (DRHT) modified-FOLFIRINOX patients.In this study, we conducted a...
Abnormal expression of long non-coding RNAs (lncRNAs) has been shown to be associated with the pathogenesis cancers, including colorectal cancer (CRC). It reported that LINC00022 is highly expressed in some typs and its overexpression indicates poor prognosis. The function CRC progression remains unclear mainly investigated present study.LINC00022 tissues was analyzed by using TNMplot software. cells measured quantitative real-time PCR. effects on malignant behaviors were detected a series...
Abstract The function of M‐Phase Phosphoprotein 9 (MPHOSPH9) has not been investigated in gastric cancer yet. In the present study, public databases Oncomine and TCGA were analyzed, MPHOSPH9 was found upregulated tumor tissues. Immunohistochemistry (IHC) also carried out to further confirm results, IHC analysis showed elevated tissues compared with paracancerous QRT‐PCR revealed that mRNA cell lines. addition, Kaplan–Meier estimates patients high level predicted a poor prognosis. Then,...
Abstract Background: Whether whey protein supplementation can reduce the occurrence of hypoproteinemia in patients with acute critically ill neurological diseases on basis standard intact EN has not been confirmed by randomized controlled clinical trials. Objective: We evaluated effect powder serum albumin patients. Methods: Critically expected to stay longer than 7 days were randomized. For formula (IPF) group, only an was given. (WPF) added formula. Results: The level WPF group higher that...