A5054957303- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cancer-related molecular mechanisms research
- Neurological Disease Mechanisms and Treatments
- RNA regulation and disease
- Cerebrovascular and Carotid Artery Diseases
- Diabetic Foot Ulcer Assessment and Management
- Gut microbiota and health
- Inflammasome and immune disorders
- Peripheral Artery Disease Management
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Myocardial Infarction Research
- Intracranial Aneurysms: Treatment and Complications
- RNA modifications and cancer
- Clinical practice guidelines implementation
- Neurological Disorders and Treatments
- MicroRNA in disease regulation
- Coronary Interventions and Diagnostics
- AI and Big Data Applications
- Probiotics and Fermented Foods
- Cancer Research and Treatments
- Applied Advanced Technologies
- Advanced Technologies in Various Fields
- Intracerebral and Subarachnoid Hemorrhage Research
Shanghai Medical College of Fudan University
2025
Hebei North University
2016-2024
Weatherford College
2024
Neuroinflammation and neuronal apoptosis are considered as the critical factors in pathogenesis of multiple neurological diseases. Recent studies have shown that long non-coding RNA (lncRNA) plays a crucial part neuroinflammation apoptosis.The expression levels lncRNA KCNQ1OT1, miR-30e-3p NLRP3 lipopolysaccharide (LPS)-induced HMC3 cells were analyzed using RT-qPCR. MTT assay, LDH release assay ELISA used to assess effect KCNQ1OT1 on apoptosis. The targeted regulatory relationships among...
Objective: To explore the prognostic value of ankle brachial index (ABI), serum microribonucleic acid-103 (miR-103), and lipoprotein associated phospholipase A2 (LP-PLA2) indicators in patients with acute ischemic stroke (AIS).
 Methods: A retrospective analysis was conducted using medical records 202 AIS admitted to First Affiliated Hospital Hebei North University from June 2019 December 2022. Patients were divided into two groups based on their prognosis: Poor-group (n=72) Good-group...
Long non-coding RNA zinc finger antisense 1 (lnc-ZFAS1) has been reported to inhibit neuronal damage in acute ischemic stroke (AIS). However, the role of lnc-ZFAS1 AIS patients remains unclear. Therefore, we assessed relationship with neurological impairment, inflammation, and prognosis patients.Totally, 241 120 controls were enrolled. peripheral blood mononuclear cells was evaluated using reverse transcription-quantitative polymerase chain reaction. Besides, a 3-year follow-up conducted...
To explore the application value of an integrated emergency care model based on failure modes and effects analysis (FMEA) in patients with acute ischemic stroke (AIS).According to convenience sampling method, 100 AIS who visited department our hospital from October 2018 March 2019 were randomly selected as control group received routine mode intervention. Another April intervention FMEA. The total time spent admission completion each procedure [total physician reception (T0-1), team (T0-2),...
Long noncoding RNA intersectin 1-2 (lnc-ITSN1-2) regulates inflammation and neuronal apoptosis; meanwhile, the latter two factors participate in pathogenesis of acute ischemic stroke (AIS). Therefore, this study detected lnc-ITSN1-2 at multiple time points, aiming to explore its longitudinal variation clinical value management AIS patients.The current enrolled 102 patients, then their peripheral blood mononuclear cell (PBMC) baseline (D0), day (D)1, D3, D7, month (M)1, M3, M6, year (Y)1...
Investigate the effect of Alteplase and Aspirin on functional outcomes patients with acute ischemic stroke mild non-disabling neurological deficit. In this single-center, randomized controlled study, we selected 60 deficit admitted to our hospital from January 2021 2022, randomly divided them into study group (n = 30) control 30), was given treatment, changes in recovery, daily living ability, exercise balance cognitive function, short-term prognosis were observed these 2 groups. The factors...
Objective : To investigate the clinical effects of intravenous thrombolysis in treatment TIA (Transient Ischemic Attack) and cerebral infarction with multimodal MRI (magnetic resonance imaging), to provide a reference for diagnosis treatment. Methods Patients acute diagnosed treated were enrolled study. Multimodal was performed determine location type infarction. Based on routine care, rt-PA (Recombinant Tissue Plasminogen Activator) thrombolytic therapy applied. The NIHSS (National...
Knowledge discovery and cloud computing can help early identification of ischaemic stroke provide intelligent, humane, preventive healthcare services for patients at high risk stroke. This study proposes constructing a health management model warning based on IoT computing, discusses its connotation, constructive ideas, research content so as to reference in order develop implement countermeasures compare the awareness symptoms first aid knowledge among their families before after activity....
Objective To investigate the protective effect of cerebral ischemic preconditioning (CIPC) on ischemia/reperfusion (I/R) in rats and impact CIPC nuclear factor E2-related 2 (Nrf2)/quinone oxidoreductase 1 (NQO1) signaling pathway. Methods A total 198 healthy male Sprague-Dawley were randomly divided into 3 groups: a sham-operation group, an I/R (CIPC group). Each group was also redivided 5 subgroups: 6 h, 12 24 48 72 h after modeling according to time points. The neurological function...
This research was conducted to discuss the recent prognosis of patients with acute cerebral infarction (ACI) combined cerebral-cardiac syndrome (CCS).Eighty-seven ACI were selected, which divided into group (52 patients) and CCS (35 according whether combined, another 30 health controls selected as control group. Serum hypoxia-inducible factor (HIF)-1α vascular endothelial growth (VEGF) levels subjects in each at 1st day, 3rd 7th day after admission measured by enzyme-linked immunosorbent...
Objective : To investigate the therapeutic effect of intravenous thrombolysis on TIA (Transient Ischemic Attack) under guidance multimodal MRI (magnetic resonance imaging), and clinical application in patients with ischemic stroke. Methods Patients acute stroke who underwent Department Neurology from December 2017 to 2018 were selected. Through CT (computed tomography) screening, 146 that met diagnostic criteria eventually included. randomly divided into group A (72 patients) B (74...
Treatment decision making is strictly associated with the outcomes in patients ischemic stroke who show a large core infarct. Medical care alone may result suboptimal treatment efficacy, and endovascular be accompanied by safety issues. Whether superior to medical not well investigated clinical studies.To investigate efficacy of drug therapy mild infarct cores.Fifty 50 acute caused anterior vessel occlusion were selected at First Affiliated Hospital Hebei North University between January...