A5101835188- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Synthetic Organic Chemistry Methods
- RNA modifications and cancer
- Chemical synthesis and alkaloids
- Hydrology and Watershed Management Studies
- Lung Cancer Research Studies
- Flood Risk Assessment and Management
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Hydrological Forecasting Using AI
- Immune cells in cancer
- Head and Neck Cancer Studies
- Natural Compound Pharmacology Studies
- RNA Research and Splicing
- Cancer-related Molecular Pathways
- Effects of Radiation Exposure
- Oxidative Organic Chemistry Reactions
- Salivary Gland Disorders and Functions
- Thermal Radiation and Cooling Technologies
- Terahertz technology and applications
- Microtubule and mitosis dynamics
- Biomarkers in Disease Mechanisms
Huazhong University of Science and Technology
2008-2025
Hubei Cancer Hospital
2015-2025
Suzhou Municipal Hospital
2024
Nanjing Medical University
2024
Nanchang University
2024
Fudan University
2022
Zhongshan Hospital
2022
East China Normal University
2018-2021
People’s Hospital of Rizhao
2021
Zhongnan Hospital of Wuhan University
2018-2019
Abstract Nimustine ( ACNU ) has antitumor activities in patients with malignant glioma. Hyperbaric oxygen HBO may enhance the efficacy of certain therapies that are hampered by hypoxic microenvironment. We examined combined effects and a GFP transgenic nude mice bearing human glioma model. Mice inoculated cells SU 3 were randomly divided into four groups: (A) control group, (B) HBOT therapy) (C) (D) + group. Tumor size was measured at indicated time intervals caliper; sacrificed 28 days...
Tongue squamous cell carcinoma (TSCC), the most common epithelial cancer identified in oral cavity, has become one of malignancies across developing countries.Increasing evidence indicates that long non-coding RNAs (lncRNAs) serve as important regulators biology.The focally amplified RNA (FALEC) was found downregulated tissues tongue (TSCC) and predicted to present a good prognosis by bioinformatics analysis.Experiments indicated FALEC knockdown significantly increased proliferation...
Abstract A highly convergent approach was developed to achieve the first asymmetric and scalable total synthesis of FD‐594, a complex polycyclic xanthone natural product from Streptomyces sp . TA‐0256, in longest linear sequence (LLS) 20 steps. The trans ‐9,10‐dihydrophenanthrene‐9,10‐diol fragment (B‐C‐D ring) generated through new strategy involving dihydroxylation followed by Cu‐mediated oxidative cyclization. Late‐stage stereoselective glycosylation assembled angular hexacyclic framework...
Long non-coding RNAs (lncRNAs) have been established as pivotal players in various cellular processes, encompassing the regulation of transcription, translation and post-translational modulation proteins, thereby influencing functions. Notably, lncRNAs exert a regulatory influence on diverse biological particularly context tumor development. Tumor-associated macrophages (TAMs) exhibit M2 phenotype, exerting significant impact crucial processes such initiation, angiogenesis, metastasis immune...
To investigate the expression of long-chain noncoding growth stasis specific protein 6 antisense RNA1 (lncRNA DLX6-AS1) in nasopharyngeal carcinoma (NPC) tissues and cells, its regulatory effect on malignant phenotypes NPC cells.The expressions DLX6-AS1, miR-199a-5p, HIF-1α mRNA issues cells were detected by qRT-PCR. The proliferation, metastasis, invasion monitored via MTT transwell assay. interactions between DLX6-AS1 miR-199a-5p verified luciferase activity Western blot was performed to...
Neuroendocrine tumors (NETs) of the gastrointestinal tract often spread to liver, while primary hepatic NETs (PHNETs), first described by Edmondson in 1958, are very rare. The majority existing reports regarding PHNETs have small sample sizes, and clinicopathological characteristics prognostic factors still unclear. aim present study was analyze features explore PHNETs. From March 2012 2017, 28 cases were retrospectively evaluated patients males (n=15) females (n=13) aged between 32 76 years...
Hydrological forecasting plays a crucial role in mitigating flood risks and managing water resources. Data-driven hydrological models demonstrate exceptional fitting capabilities adaptability. Recognizing the limitations of single-model forecasting, this study introduces an innovative approach known as Improved K-Nearest Neighbor Multi-Model Ensemble (IKNN-MME) method to enhance runoff prediction. IKNN-MME dynamically adjusts model weights based on similarity historical data, acknowledging...
The synthesis of kibdelone C, a polycyclic natural xanthone isolated from soil actinomycete, was achieved through convergent approach. A 6π-electrocyclization applied to construct the highly substituted dihydrophenanthrenol fragment (B–C–D ring). InBr3-promoted lactonization employed build isocoumarin ring, which served as common precursor for formation isoquinolinone ring (A–B key DMAP-mediated oxa-Michael/aldol cascade reaction developed install tetrahydroxanthone (E–F This approach...
Abstract Background Long non‐coding RNA myocardial infarction associated transcript (MIAT) has been suspected to be with poor prognosis in several malignancies. This study aims investigate the association between MIAT expression levels and of tongue squamous cell carcinoma (TSCC). Materials Methods Expressions TSCC specimens, corresponding adjacent non‐neoplastic tissues, serums collected from 116 patients were detected by Quantitative Real‐Time PCR. Then, these followed up for 12 months...
Abstract. The spatial scale mismatch between runoff generation and routing is an acceptable compromise but a common issue in challenging hydrological modelling. Moreover, there hardly any report available on whether unit hydrograph (UH) that consistent with the of can be computed. objective this study was to explore influence heterogeneity UH for flood prediction. To end, novel GIS-based dynamic time-varying (DTDUH) proposed based (TDUH). DTDUH defined as typical direct which gets generated...
The purpose of this study is to systematically the cell-cycle alterations glioblastoma stem-like cells (GSLCs) after irradiation, possibly enriching mechanisms radioresistance GSLCs.GSLCs were enriched and identified, then GSLCs was validated by analyzing cell survival, proliferation, radiation-induced apoptosis. discrepancy distribution expression cell-cycle-related proteins between differentiated (GDCs) irradiation completely analyzed.The survival fractions viabilities significantly higher...
We report the first asymmetric total synthesis and structural determination of calixanthomycin A. Taking advantage a modular strategy, concise approach was developed to assemble hexacyclic skeleton with both enantiomers lactone A ring. Stereoselective glycosylation coupled angular framework monosaccharide fragment produce its stereoisomers. This enable us determine assign absolute configuration C-25 (25S) (derivative l-glucose).
Abstract A highly convergent approach was developed to achieve the first asymmetric and scalable total synthesis of FD‐594, a complex polycyclic xanthone natural product from Streptomyces sp . TA‐0256, in longest linear sequence (LLS) 20 steps. The trans ‐9,10‐dihydrophenanthrene‐9,10‐diol fragment (B‐C‐D ring) generated through new strategy involving dihydroxylation followed by Cu‐mediated oxidative cyclization. Late‐stage stereoselective glycosylation assembled angular hexacyclic framework...
A new approach was developed to achieve the asymmetric total synthesis of (+)-PD-116740, an angucyclinone from actinomycete isolate (WP 4669). sequence dihydroxylation followed by oxidative cyclization applied stereoselectively construct core trans-9,10-dihydrophenanthrene-9,10-diol B–C–D ring. Cu salt Cu(OH)OTf·NMI2 found be best oxidant induce coupling and phenol oxidation.
Glioblastoma multiforme (GBM) is the most common malignancy in central nervous system. A small subpopulation of GBM cells known as stem-like (GSLCs) were supposed to be malignant among they are resistant multiple therapies including radiotherapy. In this study, we set up two GSLCs cell lines from parental U87 and U251 glioma lines, studied expression apoptosis-related genes alteration before after irradiation. We found that one receptors TNF-related apoptosis-inducing ligand (TRAIL), DR5,...