A5013732820- Head and Neck Cancer Studies
- Head and Neck Surgical Oncology
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Lung Cancer Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Inflammatory Biomarkers in Disease Prognosis
- Advanced Radiotherapy Techniques
- Lung Cancer Research Studies
- Epigenetics and DNA Methylation
- Viral-associated cancers and disorders
- Cancer-related gene regulation
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Brain Metastases and Treatment
- Single-cell and spatial transcriptomics
- Endoplasmic Reticulum Stress and Disease
- Effects of Radiation Exposure
Nanchang University
2021-2025
Jiangxi Provincial Cancer Hospital
2021-2025
Fujian Medical University
2016-2023
Fujian Provincial Cancer Hospital
2016-2023
Hefei University of Technology
2023
Affiliated Hospital of Guizhou Medical University
2021
Guiyang Medical University
2018-2021
Northwestern Polytechnical University
2021
Sun Yat-sen University Cancer Center
2019
Sun Yat-sen University
2019
Importance Accurate staging is a fundamental step in treating patients with nasopharyngeal carcinoma (NPC) worldwide; this crucial not only for prognostication, but also guiding treatment decisions. The American Joint Committee on Cancer (AJCC)/Union International Control (UICC) tumor-node-metastasis (TNM) system the global language clinicians, researchers, and cancer registries. Continual improvement that aligns contemporary pattern of care essential. Objective To improve prognostic...
Abstract Glioma is the most common and aggressive type of primary malignant brain tumor. The N6-methyladenosine (m6A) modification widely exists in eukaryotic cells plays an important role occurrence development human tumors. However, function mechanism heterogeneous nuclear ribonucleoprotein C (HNRNPC), RNA-binding protein m6A reader gliomas remains to be comprehensively extensively explored. Herein, we found that HNRNPC mRNA overexpression were associated with a poor prognosis for patients...
Abstract This study evaluates the efficacy, optimal duration, and target population for maintenance immunotherapy (MI) in patients with de novo metastatic nasopharyngeal carcinoma (dmNPC) who have achieved disease control following systemic treatment. A multicenter retrospective cohort included 258 whose was controlled after chemoimmunotherapy locoregional radiotherapy. The primary outcome progression‐free survival (PFS), conditional restricted mean time (RMST) analyses used to determine MI...
Summary Copy number alteration (CNA) is a major type of cancer genome that drives progression. CNA signature analysis can reveal underlying etiology and provide biomarkers for treatment, existing analyzes are all performed using bulk tissue samples. However usually affect large proportion genome, the profile sample does not reflect actual profiles individual cells sample, especially in tumors with high heterogeneity, such as hepatocellular carcinoma (HCC). Furthermore, evolutionary...
Hypoxia, a hallmark of solid tumors, promotes the malignant progression and is challenging to target. Metabolic reprogramming resulting metabolic vulnerabilities provide promising strategy target tumor hypoxia. Here we systematically compared network differences between hypoxic non-hypoxic cells, developed deep learning model, "DepFormer", predict dependent genes in cells. The performance DepFormer was validated using CRISPR screening dataset. Oxidative phosphorylation identified as most...
Abstract Background Nasopharyngeal carcinoma (NPC) is associated with lymphocyte infiltration; however, the majority of research on NPC has focused role T cells, relatively little known about roles B cells and their subtypes. Therefore, we evaluated prognostic value CD20 + cell density B-cell subtypes along functional enrichment hub genes in NPC. Methods The for distant metastasis-free survival (DMFS), overall (OS), progression-free (PFS) was explored by immunohistochemistry using...
ObjectivesTo evaluate the long-term survival and role of chemotherapy in nasopharyngeal carcinoma (NPC) patients Stage II treated by intensity-modulated radiation therapy (IMRT).
Abstract Epstein‐Barr virus (EBV) Bam HI A rightward transcripts (BART) encoded microRNAs (EBV‐miR‐BARTs) are abnormally highly expressed in nasopharyngeal carcinoma (NPC). This study aims to investigate the diagnostic and prognostic performance of miR‐BART7‐3p miR‐BART13‐3p. Plasma levels EBV DNA, miR‐BART7‐3p, miR‐BART13‐3p were examined by quantitative PCR 483 treatment‐naïve NPC patients 243 controls without NPC. The was comparing plasma with rates distant metastasis during follow‐up....
Abstract Background To investigate the prognostic value of radiologic extra‐nodal extension (rENE) in stage II nasopharyngeal carcinoma (NPC). Methods Stage NPC patients with N1 category (n = 365) were enrolled and divided into three groups according to situation rENE: without rENE, suspected confirmed rENE (grades: A, infiltration surrounding fat; B, matted nodes; C, adjacent structures). Results Only high‐grade (including nodes structures) could significantly influence survival outcomes,...
Background: Glioma is the most common primary tumor of central nervous system. The conventional glioma treatment strategies include surgical excision and chemo- radiation-therapy. Interferon Gamma (IFN-γ) a soluble dimer cytokine involved in immune escape gliomas. In this study, we sought to identify IFN-γ-related genes construct prognostic model guide its clinical treatment. Methods: RNA sequences clinicopathological data were downloaded from Cancer Genome Atlas (TCGA) China (CGGA). Using...
Abstract: Nasopharyngeal carcinoma (NPC) is a rare type of head and neck cancer, with higher incidence reported only in Southeast Asia Northern Africa. Owing to the rarity NPC occurrence, no internationally accepted consensus or guideline for its diagnosis treatment available. Based on current evidences practices, Chinese experts multidisciplinary were designated develop national strategy NPC. In this consensus, we report development improving efficacy quality life patients China. The also...
Oral squamous cell carcinoma (OSCC) is a major cancer type in the head and neck region. Recent studies have reported marked rise incidence of OSCC. The present study was performed to better understand roles that long non‑coding RNAs (lncRNAs) serve OSCC carcinogenesis. levels lncRNA C5orf66 antisense RNA 1 (C5orf66‑AS1) cytochrome c1 (CYC1) tissues cells were measured through reverse transcription‑quantitative polymerase chain reaction. In addition, associated proteins analyzed by western...
Background: Several studies have shown that the hyaluronan-mediated motility receptor (HMMR) is overexpressed in various cancers and could be a potential prognostic factor. However, further research still required to determine value function of HMMR head neck squamous cell carcinoma (HNSCC). Materials Methods: Transcriptomic expression data were collected from Cancer Genome Atlas database (TCGA) Gene Expression Omnibus differences between normal tumor tissues analyzed. The correlation...
Nasopharyngeal carcinoma is an Epstein-Barr virus (EBV)-associated tumor that highly common in southern China. Our previous sequencing data demonstrated the EBV-encoded microRNA BART8-3p was most upregulated nasopharyngeal (NPC) and closely associated with metastasis of NPC. However, values plasma NPC patients have not yet been well characterized.We quantified expression by quantitative real-time PCR 205 newly diagnosed patients. Kaplan-Meier analysis used to compare overall survival (OS),...
Abstract Purpose Emerging evidence shows that immune checkpoint inhibitors lead to durable responses in a variety of cancers, including nasopharyngeal carcinoma (NPC), however, combination approaches (i.e., stereotactic body radiation therapy, SBRT) are required extend this benefit beyond subset patients. This study retrospectively evaluated eight recurrent/metastatic NPC patients, investigate how could potentiate PD-1 inhibition therapy. Methods Between September 2016 and July 2017,...
Background: Stanniocalcin 2 (STC2) expression is upregulated under multiple stress conditions including hypoxia, nutrient starvation and radiation. Overexpression of STC2 correlates with tumor progression poor prognosis. Purpose: We previously demonstrated that overexpression in nasopharyngeal carcinomas (NPC) positively radiation resistance metastasis, two major clinical obstacles to the improvement NPC management. However, it remains elusive whether a critical contributing factor for...
Cyclin-dependent kinase regulatory subunit 2 (CKS2) is a potential prognostic marker and overexpressed in various cancers. This study analyzed sequencing clinical data from The Cancer Genome Atlas (TCGA) Gene Expression Omnibus, with external validation using the Chinese Glioma (CGGA) data. CKS2 expression normal brain tumor tissue was compared. cBioPortal MethSurv were utilized to scrutinize value of methylation. set enrichment examination single-sample gene analysis employed explore...
This study aimed to construct a signature of N6-methyladenosine (m6A) regulator-related genes that could be used for the prognosis head and neck squamous cell carcinoma (HNSCC) clarify molecular immune characteristics benefits checkpoint inhibitor (ICI) therapy using prognostic define subgroups HNSCC. showed eighteen m6A regulators were abnormally expressed in Cancer Genome Atlas (TCGA) HNSCC tissues compared with those normal tissues. We constructed 12 Cox risk model, combined least...
Abstract Distant metastasis is the primary failure pattern of nasopharyngeal carcinoma(NPC) in intensity-modulated radiation therapy(IMRT) era. This study was conducted to find impact genetic variations phosphatidylinositol 3-kinase(PI3K)/phosphatase and tensin homologue(PTEN)/v-akt murine thymoma viral oncogene homologue(AKT)/mammalian target rapamycin(mTOR) pathway on risk distant NPC. We genotyped 16 single-nucleotide polymorphisms(SNPs) five core genes this from 496 patients treated by...