A5041012342- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Liver Disease Diagnosis and Treatment
- Connexins and lens biology
- Nanoplatforms for cancer theranostics
- ATP Synthase and ATPases Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer, Hypoxia, and Metabolism
- Extracellular vesicles in disease
- RNA Research and Splicing
- Circular RNAs in diseases
- Inflammasome and immune disorders
- Heat shock proteins research
- Calpain Protease Function and Regulation
- Metabolism, Diabetes, and Cancer
- Corneal Surgery and Treatments
- Neurological Disease Mechanisms and Treatments
- Trace Elements in Health
- Retinal Diseases and Treatments
- Glioma Diagnosis and Treatment
- Cell death mechanisms and regulation
- Neuroscience and Neuropharmacology Research
- Photodynamic Therapy Research Studies
- Redox biology and oxidative stress
First Affiliated Hospital of Jiangxi Medical College
2022-2025
Jiangxi Provincial People's Hospital
2021-2025
Chongqing Medical University
2024
Nanchang University
2014-2023
Jiangxi Provincial Children's Hospital
2023
Jiang Xi Institute for Drug Control
2021
Second Affiliated Hospital of Nanchang University
2017
Peking Union Medical College Hospital
2015
Chinese Academy of Medical Sciences & Peking Union Medical College
2015
Okayama University
2004-2011
Mitochondria are high dynamic organelles with frequent fission and fusion. Here, we found hypoxia stimulated Drp1 expression, mitochondrial migration in metastatic MDA-MB‑231 cells, but not non-metastatic MCF-7 cells. Inhibition of Drp1-dependent by Mdivi-1 or silencing attenuated hypoxia-induced On the other hand, cisplatin induced significant apoptosis also efficiently prevented cisplatin-induced MMP decrease, ROS production Our data suggest that only regulates breast cancer facilitates...
Retinal ischemia/reperfusion (I/R) injury is a common pathological process responsible for cellular damage in glaucoma, diabetic retinopathy and hypertensive retinopathy. Metformin biguanide drug that exerts strong effects on multiple diseases. This study aims to evaluate the protective effect of metformin against retinal I/R its underlying mechanism. induced reduction retina thickness cell number ganglion layer, alleviated I/R-induced injury. Both simulated (SIR) R28 cells down-regulated...
Glioblastoma multiform (GBM) is a highly aggressive primary brain tumor. Exosomes derived from glioma cells under hypoxic microenvironment play an important role in tumor biology including metastasis, angiogenesis and chemoresistance. However, the underlying mechanisms remain to be elucidated. In this study, we aimed explore of connexin 43 on exosomal uptake hypoxia. U251 were exposed 3% oxygen achieve hypoxia, expression levels HIF-1α Cx43, involved colony formation proliferation assessed....
Abstract Glioma is the most common and aggressive type of primary malignant brain tumor. The N6-methyladenosine (m6A) modification widely exists in eukaryotic cells plays an important role occurrence development human tumors. However, function mechanism heterogeneous nuclear ribonucleoprotein C (HNRNPC), RNA-binding protein m6A reader gliomas remains to be comprehensively extensively explored. Herein, we found that HNRNPC mRNA overexpression were associated with a poor prognosis for patients...
The exploration of non-symmetric compound for combined photothermal therapy (PTT) and photodynamic (PDT) in tumor treatment remains largely unexplored. Through a molecular design strategy, series (Y-4Cl, Y-2Br, Y-2Cl-Br) with fused - ring benzothiazole pyrrole thiophene indenone constructure were synthesized to explore its phototherapy properties, investigate their phototherapeutic respectively. Y-2Cl-Br was further formulated into nanoparticles (NPs) detailed evaluation. organic...
Abstract Alzheimer's disease, one of the most common neurodegenerative diseases, is pathologically characterized by Amyloid beta containing plaques and neurofibrillary tangles. (Aβ) induces neuronal apoptosis through intracellular Ca 2+ increase, subsequent hyperactivation cyclin‐dependent kinase 5 (Cdk5) mitochondrial abnormality. Recently, Cdk5 was identified as an upstream regulator fission during apoptosis, but underlying mechanism remains unclear. Here, in vitro phosphorylation assays...
Chemical burns are a major cause of corneal injury. Oxidative stress, inflammatory responses and neovascularization after the chemical burn aggravate damage, lead to loss vision. Although NADPH oxidases (Noxs) play crucial role in production reactive oxygen species (ROS), Noxs burn-induced injury remains be elucidated. In present study, transcription expression corneas were examined by RT-qPCR, western blot analysis immunofluorescence staining. It was found that alkali markedly upregulated...
Cisplatin (DDP) is the first-line chemotherapeutic agent for ovarian cancer. However, development of DDP resistance seriously influences effect and prognosis It was reported that can directly impinge on mitochondria activate intrinsic apoptotic pathway. Herein, role mitochondrial dynamics in chemoresistance human cancer SKOV3 cells investigated. In DDP-resistant SKOV3/DDP cells, fission protein DRP1 down-regulated, while fusion MFN2 up-regulated. accordance with expression MFN2, average...
Light emitting diodes (LEDs) are widely used to provide illumination due their low energy requirements and high brightness. However, the LED spectrum contains an intense blue light component which is phototoxic retina. Recently, it has been reported that may directly impinge on mitochondrial function in retinal ganglion cells (RGCs). Mitochondria dynamic organelles undergo frequent fission fusion events. The aim of our study was elucidate role dynamics light-induced damage neuronal R28...
Glioblastoma is the most common and aggressive brain tumor it characterized by a high mortality rate. Temozolomide (TMZ) an effective chemotherapy drug for glioblastoma, but resistance to TMZ has come represent major clinical problem, its underlying mechanism yet be elucidated. In present study, role of exosomal connexin 43 (Cx43) in glioma cells cell migration was investigated. First, higher expression levels Cx43 were detected TMZ‑resistant U251 (U251r) compared with those TMZ‑sensitive...
Age-related macular degeneration is a common cause of blindless among the aged, which can mainly be attributed to oxidative stress and dysregulated autophagy in retinal pigment epithelium cells. Lactate was reported act as signaling molecule exerted beneficial effect against stress. This study aims investigate protective lactate stress-induced degeneration. Here, H2O2-induced cell model sodium iodate-induced mice were established. It found that H2O2 inhibited viability ARPE-19 cells iodate...
Long noncoding RNAs (lncRNAs) are related to the development of atherosclerosis (AS). However, role lncRNA metastasis associated lung adenocarcinoma transcript 1 (MALAT1) in tumor necrosis factor‑α (TNF‑α)‑induced rat aortic endothelial cell (RAOEC) pyroptosis, as well underlying mechanisms, remain unclear. RAOEC morphology was assessed using an inverted microscope. The mRNA and/or protein expression levels MALAT1, microRNA(miR)‑30c‑5p and connexin 43 (Cx43) were reverse...
The proliferation of pulmonary artery smooth muscle cells (PASMCs) is an important cause vascular remodelling in hypoxia-induced hypertension (HPH). However, its underlying mechanism has not been well elucidated. Connexin 43 (Cx43) plays crucial roles cell various cardiovascular diseases. Here, the male Sprague-Dawley (SD) rats were exposed to hypoxia (10% O2 ) for 21 days induce rat HPH model. PASMCs treated with CoCl2 (200 µM) 24 h establish It was found that up-regulated expression Cx43...
Corneal alkali burn, one of the most serious ophthalmic emergencies, is difficult to be cured by conservative treatments. It well known that oxidative stress, inflammation and neovascularization are main causes corneal damage after but its underlying mechanism remains elucidated. Here, we reported expression phosphorylation (Ser616) mitochondrial fission protein Drp1 were up-regulated at day 3 while fusion Mfn2 was down-regulated. The ERK1/2 in corneas increased 1, 3, 7 peaked burn. In human...
Gastric cancer (GC) is one of the most common tumors worldwide, and cisplatin a standard chemotherapeutic reagent for GC treatment. However, chemoresistance an inherent challenge which limits its application effectiveness in clinic. This study aims to investigate mechanism metformin-induced resistance GC. Intriguingly, upregulation mitophagy markers, mitochondrial fission, autophagy mitophagosome were observed SGC-7901/DDP cells compared those SGC-7901 cells. Treatment with metformin...
Age-related macular degeneration (AMD) is the leading cause of vision loss among elderly, which primarily attributed to oxidative stress-induced damage retinal pigment epithelium (RPE). Human amniotic mesenchymal stem cells (hAMSC) were considered be one most promising for clinical application due their low immunogenicity, tissue repair ability, pluripotent potential and potent paracrine effects. The conditional medium (hAMSC-CM) exosomes (hAMSC-exo) derived from hAMSC, as mediators...
Nonalcoholic fatty liver disease (NAFLD) is a prevalent hepatic in the world. Disorders of branched chain amino acid (BCAA) metabolism involved various diseases. In this study, we aim to explore role BCAA development NAFLD and protective effect BCATc Inhibitor 2, an inhibitor cytosolic transaminase, against as well its underlying mechanism. It was found that oleic induced lipid accumulation apoptosis HepG2 LO2 cells. Supplementation BCAAs further aggravated acid-induced apoptosis. contrast,...