A5100346501- Cancer-related Molecular Pathways
- Microbial Natural Products and Biosynthesis
- Ubiquitin and proteasome pathways
- RNA Interference and Gene Delivery
- Plant-based Medicinal Research
- Analytical Chemistry and Chromatography
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- Cancer Research and Treatments
- Mathematical and Theoretical Epidemiology and Ecology Models
- Fungal Biology and Applications
- Traditional Chinese Medicine Analysis
- Synthetic Organic Chemistry Methods
- Monoclonal and Polyclonal Antibodies Research
- Enzyme Catalysis and Immobilization
- Nanoplatforms for cancer theranostics
- Bioactive Natural Diterpenoids Research
- Extracellular vesicles in disease
- Nanoparticle-Based Drug Delivery
- RNA modifications and cancer
- Chemical synthesis and alkaloids
- Glycosylation and Glycoproteins Research
- Ferroptosis and cancer prognosis
- Berberine and alkaloids research
- Epigenetics and DNA Methylation
Sichuan University
2013-2024
South China University of Technology
2022-2024
Chengdu University
2015-2024
Xiamen University
2020-2024
Institute of Molecular Functional Materials
2024
Guangxi Normal University
2019-2024
Eli Lilly (United States)
2024
Chinese Academy of Sciences
2009-2023
Kunming Institute of Zoology
2023
Qingdao University
2023
Scope Age‐related increases in retinal iron are involved the development of degeneration. The recently discovered iron‐dependent mechanism cell death known as ferroptosis has been linked to a wide range pathologies. However, its role overload‐induced degeneration is still uncertain. Puerarin associated with protection. purpose this research determine how puerarin prevents under overload conditions. Methods and results Models Kunming mice, 661W cell, ARPE‐19 established. Increased deposition...
The development of anticancer drugs to treat triple-negative breast cancer (TNBC) is an ongoing challenge. Immunogenic cell death (ICD) has garnered considerable interest worldwide as a promising synergistic modality for chemoimmunotherapy. However, only few or treatment modalities can trigger ICD response and none them exert clinical effect against TNBC. Therefore, new agents with potentially effective chemoimmunotherapeutic are required. In this study, five cyclometalated Ir(III) complexes...
A novel type of nanovehicle (NV) based on stimuli‐responsive supramolecular peptide‐amphiphiles (SPAs, dendritic poly (L‐lysine) non‐covalently linked (L‐leucine)) is developed for intracellular drug delivery. To determine the pH‐dependent mechanism, peptide‐amphiphile system (SPAS) investigated at different pH conditions using a variety physical and chemical approaches. The pH‐triggered disassembly SPAS can be attributed to disappearance non‐covalent interactions within SPAs around...
Asymmetric total synthesis of the dimeric diterpenoid hispidanin A was accomplished by non-catalytic Diels-Alder cycloaddition at room temperature. The relies on iron-catalyzed coupling to construct a Z-configured trisubstituted alkene, an radical cascade generate labdane-type diene, and both Yamamoto cationic polyene cyclization palladium-catalyzed Stille totarane-type dienophile.
A platinum(ii) complex containing an aminophosphonate ligand preferentially accumulates in the endoplamic reticulum (ER) association with potent ER stress and reactive oxygen species generation, followed by activation of damage-associated molecular pattern signals immune responses. Importantly, Pt exhibits anti-tumour activities two independent mouse models via immunogenic cell death pathway.
Atisane-type compounds and related natural products are attractive for their molecular skeletons pharmaceutical bioactivities. This review summarizes total syntheses of atisane-type diterpenoids diterpenoid alkaloids. 1 Introduction 2 Total Synthesis Synthetic Studies Atisane-Type Diterpenoids Related Diterpenoid Alkaloids 2.1 Ionic Methods 2.1.1 S<sub>N</sub>2 Substitution Reaction 2.1.2 Aldol 2.1.3 Intramolecular Double Michael Addition 2.2 Free-Radical 2.2.1 Rearrangement 2.2.2 2.3...
Glioblastoma multiform (GBM) is a highly aggressive primary brain tumor. Exosomes derived from glioma cells under hypoxic microenvironment play an important role in tumor biology including metastasis, angiogenesis and chemoresistance. However, the underlying mechanisms remain to be elucidated. In this study, we aimed explore of connexin 43 on exosomal uptake hypoxia. U251 were exposed 3% oxygen achieve hypoxia, expression levels HIF-1α Cx43, involved colony formation proliferation assessed....
Although immunotherapy of hepatocellular carcinoma using immune checkpoint inhibitors has achieved certain success, only a subset patients benefits from this therapeutic strategy. The combination immunostimulatory chemotherapeutics represents promising strategy to enhance the effectiveness immunotherapy. However, it is hampered by poor delivery conventional chemotherapeutics. Here, shown that H-ferritin nanocages loaded with doxorubicin (DOX@HFn) show potent chemo-immunotherapy in tumor...
Chemotherapeutics can induce immunogenic cell death (ICD) in tumor cells, offering new possibilities for cancer therapy. However, the efficiency of immune response generated is insufficient due to inhibitory nature microenvironment (TME). Here, we developed a pH/reactive oxygen species (ROS) dual-response system enhance chemoimmunotherapy melanoma. The productively accumulated tumors by specific binding phenylboronic acid (PBA) sialic acids (SA). nanoparticles (NPs) rapidly swelled and...
Hydrogel wound dressing for irregular shape and deep repair is a research hotspot. Herein, multifunctional self-adaptive double-layer hydrogel was constructed, which comprised of chitosan-based inner layer gellan gum-based outer hydrogel. Various properties were systematically investigated, including injectability, shape-adaptability, solid-liquid phase transition, biocompatibility, hemostasis, antibacterial performance anti-inflammatory. Thanks to the phase-transition from solid liquid at...
Both the accumulation of reactive oxygen species (ROS) and iron overload are significant variables that enhance incidence photoreceptor cell death retinal degeneration. The discovery ferroptosis, which is characterized by iron-dependent lipid peroxidation, has led to a new perspective on how degeneration develops. As natural phenolic acid, salvianic acid A (SAA) from Salvia miltiorrhiza promise in treating eye diseases. purpose this research was learn more about SAA its function development...
Total synthesis of nannocystin Ax has been accomplished concisely. The key elements in this total feature Kobayashi's remote asymmetric induction with vinylketene silyl <italic>N</italic>,<italic>O</italic>-acetal, Roush's crotylboration aldehyde, Mitsunobu's esterification and macrocyclization <italic>via</italic> Stille cross-coupling.
Abstract Methoxy poly(ethylene glycol)–poly( L ‐histidine)–poly(lactide) (mPEG 45 –PH 30 –PLA 82 ) triblock copolymers self‐assemble into nanoparticles by sterocomplexation. The properties of the stereocomplex including morphology, stability, and biocompatibility are investigated. results reveal that stereocomplexation between PLLA PDLA segments could prevent aggregation when pH value is around 6.8. mean diameter stabilized at about 100 nm values changed from 7.9 to 5.0. cytotoxicity...